Candles viferon 1 instructions for use. Candles for children Viferon: instructions for use, composition, indications and analogues

Children often suffer from colds and acute viral infections, especially in the first years of life. This is because their immune system has not yet been formed, so they are vulnerable to viral and bacterial attacks. Pathogenic microbes enter the body, actively multiply, worsen the condition of the child. In such cases, complex treatment with the use of immunomodulators is necessary.

Viferon is a drug with a pronounced antiviral and antibacterial effect. The drug stimulates the body's defenses, speeds up recovery and prevents complications. Can Viferon be used by a child for the treatment and prevention of diseases of viral and bacterial origin? More on this later.

Description of dosage forms

Most suitable for children pharmaceutical form- these are rectal suppositories 150,000 IU. For adults, the drug is produced with a concentration active component 500,000 and 1,000,000 IU. These are torpedo-shaped candles, white or yellowish in color. Suppositories with a diameter of about 1 cm and a soft consistency are easily inserted into anus.

  • interferon α-2b;
  • α-tocopherol acetate;
  • vitamin C;
  • sodium salt of ascorbic acid;
  • Twin 80;
  • disodium salt of ethylenediaminetetraacetic acid;
  • cocoa butter;
  • cooking oil.

In addition, the drug is produced in the form of an ointment and gel, which have the following composition:

Viferon ointment:

  • interferon α-2;
  • tocopherol acetate;
  • anhydrous form of lanolin;
  • petrolatum;
  • peach oil;
  • distilled water.

  • interferon α-2b;
  • α-tocopherol acetate;
  • methionine;
  • additive E210;
  • food additive E330;
  • technical drill;
  • sodium chloride;
  • human albumin solution (10%);
  • glycerol;
  • carmellose sodium;
  • ethyl alcohol (95%);
  • distilled water.

The preparation in the form of a gel looks like a homogeneous mass of a gray-white hue, and the ointment is a homogeneous substance with the aroma of lanolin.

Properties of Viferon

Interferon α-2b (the main component) is synthetic analogue human interferon natural origin. These proteins respond to the invasion of harmful microorganisms.

A protein compound has the following properties:

  • Interferon binds to receptors on the membrane of the virus and inhibits its reproduction inside the infected cell.
  • The substance stimulates functional activity immune system. In addition, interferon improves the functioning of cellular and humoral immunity. The protein compound enhances the production of secretory igA (immunoglobulin A) and normalizes the concentration of class E immunoglobulin, which detects diseases of an allergic nature.
  • Interferon has an antiproliferative effect. The substance inhibits the excessive reproduction of cells in the focus of infection. In addition, Viferon suppositories have an antitumor effect.
  • Interferon stimulates phagocytic activity. As a result, macrophages (immune cells) engulf pathogens faster.
  • The substance stimulates the cytotoxic activity of white blood cells(leukocytes) in relation to infected cells.

Vitamin C reinforces medicinal properties interferon. In addition, it inhibits the oxidation of organic compounds, stabilizes cell membranes, and promotes the restoration of damaged tissues.

Suppositories act 15 minutes after application. The components penetrate into the bloodstream, stimulate the immune system, and eliminate inflammation.

Indications

As the instruction says, Viferon suppositories are used to treat diseases of viral and bacterial origin:

  • Diseases of the respiratory organs viral nature, including influenza severe form or a complicated infection of bacterial origin against the background of a decrease in immunity.
  • Infectious and inflammatory diseases (inflammation of the mucous membranes of the head and spinal cord viral or bacterial origin, bacterial sepsis). Intrauterine diseases caused by cytomegaloviruses, enteroviruses, chlamydia, ureaplasmas and herpes viruses. The drug is used as part of complex treatment.
  • Hepatitis B, C, D, E of viral origin with chronic course. The drug is taken in combination.
  • infections urinary organs in chronic form. Chlamydial infection, ureaplasmosis, bacterial vaginosis, thrush, etc.
  • Herpes on the skin or internal membranes with a chronic relapsing or severe course.

In addition, suppositories improve the functional activity of the immune system during diseases of bacterial origin in a chronic form.

Rules for use and dosage

As already mentioned, Viferon suppositories for children are used rectally, that is, they are injected into the rectum. Before using the drug to treat a child, you need to familiarize yourself with the technology of introducing a suppository:

  1. Wash your hands with antibacterial soap.
  2. Remove the suppository with an interferon concentration of 150,000 from the blister.
  3. Turn the child on its side or lay it on its back, bend its knees.
  4. Gently insert the suppository with a pointed tip into the anus. The permissible depth of insertion is 2 cm. Press with your little finger on the blunt side of the candle. Before insertion, you can treat the perianal area (the area around the anus) with petroleum jelly or baby cream. However, this paragraph can be skipped, since the candle already contains fatty substances, which heat up on contact with the skin, and therefore do not cause discomfort.
  5. Squeeze your buttocks for a couple of minutes so that the suppository does not slip out.

Daily dosage of the drug for children of different ages:

  • from 0 to 12 months - 1 suppository twice with an interval of 12 hours. If the child is premature, then the interval between injections is 8 hours. The therapeutic course lasts 5 days, if necessary, the pediatrician will extend the treatment. At viral hepatitis children under 6 months are injected with about 500,000 IU of interferon in 24 hours.
  • from 1 to 7 years - 1 suppository twice, the treatment lasts 5 days.
  • from 8 to 12 years old, suppositories with an interferon concentration of 500,000 IU are used. Daily dose - 1 suppository twice for 5 days.

Before using the drug, you need to visit a pediatrician who will establish a diagnosis, determine the dose, frequency and duration of Viferon use.

Viferon for the prevention of infections of viral origin guarantees excellent result. The dose of the drug is determined by the doctor depending on the age of the patient.

special instructions

Patients tolerate suppositories well, they are forbidden to be used only in case of hypersensitivity to the components of the drug.

If there are contraindications, adverse reactions in the form of an allergy:

  • rash;
  • nettle fever.

There is no information on severe allergic reactions in the form of Quincke's edema or anaphylaxis.

Before using the drug, it is recommended to carefully study the instructions. There are several points that require special attention:

  • The components of the drug joint application do not enter into chemical reactions with medicines of other pharmacological groups.
  • At simultaneous application Viferon and antibacterial drugs for the treatment of infections of bacterial origin first enhances therapeutic effect others.
  • After the occurrence of allergies, you should stop taking the drug. Thereafter negative reactions will disappear 3 days after cancellation.
  • Suppositories are allowed to be used by newborns. In addition, the drug in this form is compatible with pregnancy and lactation. However, the doctor must monitor the condition of a special group of patients.
  • The drug does not affect the patient's memory and attention, does not disrupt psychomotor reactions.

The drug is released without a prescription.

Similar drugs

In the presence of hypersensitivity to the components of the drug, Viferon can be replaced with drugs with a similar active substance and mechanism of action:

  • Laferobion based on interferon α-2b is also produced in the form of rectal suppositories. The drug is used to treat diseases of the respiratory organs of viral origin and influenza. The drug stimulates the immune system, eliminates pathogens.
  • Alfarekin contains a similar active ingredient. Rectal suppositories are used to treat infections of viral and bacterial origin. The drug is intended for newborns from 3 months.
  • Alfaron is made in the form of a lyophilisate for the preparation of an intranasal solution. The drug is prescribed for the treatment of influenza in children from birth.

Thus, Viferon is a universal complex drug for the prevention and treatment of viral and bacterial infections. The medication causes side effects only if you are allergic to its components. Before using the drug for the treatment of children, you should consult a pediatrician.

This drug is effective in viral infections. It is prescribed for children, adults, and pregnant women. In order to avoid negative consequences after taking Viferon, it is better to study the instructions before starting treatment.

In pharmacies you can find ointment, gel and rectal suppositories Viferon. Perhaps you have not used preparations in the form of suppositories before, especially rectal ones, the name of the suppository is due to the fact that their scope is the rectum (from Latin rectum). In it, the absorption of the mucosal drug takes place and its further entry into the blood.

Viferon suppositories mainly consist of an active ingredient - interferon human recombinant alpha-2, this is the name of a synthetic protein that is obtained by laboratory geneticists. He is exactly the same as human interferon produced by an organism that is immune response for bacterial or viral infection. Instructions for use of Viferon suppositories states that the effect of the drug is based on the joint work of artificial interferon together with natural and activation of the production of the latter.

Interferon alpha-2 has the highest antiviral efficacy, it differs from similar immunomodulatory drugs in good performance against influenza, herpes, hepatitis and similar diseases. Diseases that appear against the background of the presence of atypical bacteria or protozoa, ureaplasmosis, chlamydia, gardnerellosis, trichomoniasis respond well to interferon treatment with drugs containing this protein.

From infections caused by fungi, such as candidiasis and mycoplasmosis, the use of interferon is also effective. As you know, Arbidol, Kagocel, Anaferon also contain interferon, in particular, many effective drugs have been created on its basis.

It is worth noting that Viferon contains substances that activate its effectiveness and eliminate possible side effects. For example, the ointment contains vitamin E, and the composition of the gel, in addition to tocopherol acetate, is represented by benzoic and citric acid, methionine solution containing alcohol and a substance that has no less effective immunomodulatory properties than interferon - human serum albumin.

note

Candles have high performance and a strong antioxidant effect due to vitamin E and ascorbic acid. Also, in any dosage form, regardless of whether it is a suppository or an ointment, additional components are contained, full squad which are described in detail in the instructions for the drug.

It should be noted that before starting treatment, you should learn in detail about the composition of the drug (this applies not only to Viferon), especially if there is an allergy, because if you are intolerant of any component contained in the suppositories, you cannot use this form of the drug.

Do not use suppositories if the body has shown individual sensitivity to the substances contained in the drug. In particular, such a reaction may occur to ascorbic acid and alpha-tocoverol acetate. During pregnancy, not earlier than 14 weeks, Viferon suppositories are allowed to be used. Instructions for use do not contain information about the contraindication of the drug during breastfeeding.

This drug is distinguished by safety, thanks to which its use is allowed even for newborns. During treatment, adverse reactions may develop, such as skin rashes, however, after stopping the intake for three days, the manifestations of the rash will disappear. In the event of any reactions after the start of treatment, a mandatory consultation with a doctor is necessary. In any case, it should be noted that such adverse reactions are not life-threatening, stop within 3 days and do not require additional therapy.

Viferon suppositories for adults: in what cases are they prescribed

This drug is also called human recombinant interferon, which is its international name. He is rectal suppositories yellowish color having a diameter of not more than 1 cm. It is produced with an interferon content identical to that produced by the human body.

Its action is based on joint work with natural interferon, as well as stimulation of its production. Ascorbic acid and vitamin E, also included in the preparation, activates the immunomodulatory and antiviral effect thus stimulating the body's immune response to bacterial infection. Ascorbic acid and alpha-tocopherol acetate also have a high antioxidant, anti-inflammatory and regenerating effect. . Viferon suppositories for adults stop development inflammatory processes , also cell membranes resume their full-fledged work. With these substances, interferon acts more effectively, prompting the body to fight on its own.

note

When treatment with Viferon occurs in conjunction with antibiotic therapy, the latter can be administered at a lower dose, which reduces Negative consequences treatment on the human body. When Viferon is used for a long time, the formation of antibodies that neutralize its effect is not observed.

In what cases is Viferon prescribed? This drug can be used regardless of age, treatment with Viferon is prescribed even for newborns and premature babies.

It is effective for children with the following diseases:

  • SARS, colds that have bacterial complications or without them;
  • pneumonia of various etymologies;
  • infectious diseases in newborns;
  • viral hepatitis;
  • as preventive measure from ARVI, acute respiratory infections, influenza to children prone to frequent illnesses;
  • as a fortification defensive forces when the body is weakened by an infection.

The instructions describe in detail the use of the drug, the dosage and duration of treatment is prescribed by the attending physician. The release of Viferon suppositories occurs with different amounts of interferon, so you can pick them up for a child of any age with the right dosage in 1 candle, it also eliminates the excess required dose, you just need to carefully choose the drug when buying, in order to strictly follow the doctor's prescription.

Between the use of candles, it is desirable to observe the same intervals of time. For the treatment of influenza, acute respiratory viral infections, acute respiratory infections, it is recommended to apply rectally 1 suppository twice a day with a five-day course of treatment. In other cases, treatment may last longer - 10-60 days, depending on the course of the disease. Also, the effect of treatment is affected by compliance with the rules for the use of the drug, in particular in newborns.

Candle insertion technology:

  • The procedure is carried out in sterile gloves or cleanly washed (disinfected) hands.
  • For a baby lying on his stomach or on his side, make a deep introduction of the suppository into the anus.
  • Continue to lie without changing position for at least 10 minutes to completely dissolve the drug.
  • For older children, the introduction of suppositories should be done after defecation.

Pregnancy. Adult dosage Viferon 4 is not used for pregnant women when gynecological and other diseases occur, expectant mother a small dosage of the drug is needed, usually for adolescents (1,000,000 IU) or children (50,000 IU). But even in this case, there are certain restrictions for pregnant women, Viferon is prescribed no earlier than 14 weeks and only during the period breastfeeding candles are prescribed without any fear. In principle, even during pregnancy planning, it would be more correct to treat all diseases, the treatment will be more effective, because when choosing required drug there will be no restrictions.

Candles Viferon, used in the rectum, have only general action, Unlike vaginal preparation Genferon, who treats locally. Of course, it is useless for viral infections, but urogenital diseases are better treated with Genferon.

It relieves pain due to the fact that it contains benzocaine and the amino acid taurine, in particular, the use of benzocaine and is contraindicated during pregnancy. Preparations with its content can be prescribed only in the second half of the term, and then the expected benefit should exceed possible harm for the baby.

note

It is very important to follow the doctor's prescription exactly and not change it yourself without prior consultation, especially since Genferon and Viferon are not equally safe for pregnant women. Only the attending physician knows which drug you need.

As you know, even drugs used rectally enter the blood, but side effects suppositories Viferon are not as extensive as those of subcutaneous, intramuscular and intravenous drugs with interferon in the composition. If you do not understand this mechanism, you can search Additional information about the absorption of substances by the intestines, however, it becomes obvious that the use of Viferon in the form of rectal suppositories is much less likely to have negative consequences, even less local ointments and gels.

In fairness, it should be noted that treatment with Viferon, like with any drug, may not be complete without side effects. By the way, Russian manufacturers the list of possible consequences is very detailed in the attached instructions, so you need to carefully read it before starting treatment.

Rectal suppositories Viferon and their use for the treatment of children

Most often, mothers of newborns and pregnant women are looking for additional information about taking the drug, there is nothing strange in this: usually Viferon rectal suppositories are prescribed to treat infants from respiratory and herpes infections, atypical pneumonia and similar diseases representing a direct threat to the life of a newborn baby.

Often the appointment of Viferon and gynecologists- it successfully cures vaginal infections of fungal, bacterial or viral nature, as well as infectious diseases, such as: influenza, acute respiratory infections and others. The appointment of this drug by gynecologists, neonatologists and pediatricians in itself serves as a convincing argument that it has low toxicity, in addition, there are no serious side effects from its use.

The action of suppositories occurs locally, the components of the drug are absorbed in the rectum and then enter the bloodstream. Therefore, it is necessary that the interferon contained in the preparation be in the exact dosage.

Manufacturers took care of this, releasing Viferon in the form of candles with different dosage active substance:

  • Infants and children under the age of one are prescribed Viferon 1 (contains 150 thousand IU).
  • At the age of 1-7 years, Viferon 2 (500 thousand IU) is used.
  • For children 7-12 years old, the dosage of Viferon 3 is suitable.
  • For teenagers and adults Viferon 4 (3 million IU).

Be sure to follow exactly the dosage prescribed by the doctor, and also use the drug, as indicated in the instructions for it, in strict accordance with age. It is strictly forbidden to use a large dosage of suppositories to treat a newborn, but a low dosage for older children will also be ineffective. As a rule, all negative reviews about the low effectiveness of the drug are associated with the use of a dose that is not appropriate for the age of the child.

Candles Viferon for prostatitis, features of their use for treatment

The prostate is the second heart of a man, men are especially reverent about the state of her health, but from time to time problems occur with this piece of iron, and therefore the treatment of inflammatory diseases of this important body should be taken very seriously.

For a long time in the complex drug therapy prostatitis, Viferon rectal suppositories are used, which fight viruses and induce the immune system to more active work. Antiviral action It is provided due to the fact that interferon destroys RNA and DNA, which are the basis of life and replication of viruses that invade cells and damage them.

Stimulation of the immune system occurs because interferon activates T and B lymphocytes, increases the phagocytic activity of cells immune protection- macrophages. Also, Viferon suppositories with prostatitis normalize the level of immunoglobulin E, and therefore, the overall immune response of the body, directed against pathogenic microorganisms, increases.

Viferon rectal suppositories contain vitamins E and C, known as antioxidants, due to this, the anti-inflammatory effect of the drug is significantly enhanced, in addition, the lipid layer is protected cell membranes from peroxidation.

The drug enhances the ability of tissues to recover, this confirms the validity of the appointment of Viferon suppositories for various forms inflammatory diseases of the prostate. Viferon suppositories for prostatitis work well in combination with other medicines, especially antibiotics a wide range actions, and therefore can be applied in complex treatment prostatitis.

1-2 suppositories are administered per day with an interval of 12 hours. The course of treatment is 5 days.

AT pharmacy network there are preparations similar to these suppositories, they are identical in composition, pharmacological action and curative effect.

Sometimes the difference is only in a different commercial name, for example:

  • Laferobion.
  • Laferon.
  • Interferon.
  • Genferon.
  • Lipoferon.

The price of rectal suppositories Viferon is quite high due to the uniqueness technological process in its production, but when it comes to health, especially the health of such an important organ as the prostate, then the price should be the last thing to think about.

I would like to warn patients against the danger of buying the drug at 2 times cheaper than the current price. There is a high probability of acquiring a fake, and this will not help recovery, and can be harmful.

suppositories rectal Viferon sold in pharmacies without a doctor's prescription. However, despite the safety of use, it is recommended to consult a doctor, a specialist, after full examination will establish the correct diagnosis and prescribe individual treatment in a timely manner.

Most men of different age groups noted a decrease pain syndrome, improvement of urination for 2-4 days from the start of the use of suppositories.

According to the reviews of mothers who used candles in the treatment colds in children, more easy current disease, faster recovery and no complications of the disease, the earlier treatment was started, the better the result.

In conclusion, it should be noted that in addition to the use in the treatment of prostatitis, Viferon is widely used in pediatric and general therapeutic practice. Candles can also be used complex therapy severe infections, sepsis, meningitis, fungal infections, chlamydia, mycoplasmosis, all forms of chronic viral hepatitis.

"Viferon" refers to antiviral agents, a relatively new range of drugs. Instructions for the use of candles "Viferon" for children contains little information about long-term consequences his acceptance. This is due to the fact that medicine still does not have enough data to evaluate. However, it is important for parents to understand how harmless the drug is, which is prescribed even for babies up to a year old.

The main problem with viral infections is that there are antibiotics against bacteria, but nothing has been developed against viruses. If bacteria, protozoa and even fungi are separate microorganisms, then the virus is a fragment foreign DNA, which the:

  • "adds" itself to the DNA of the body's own cells;
  • becomes due to this unrecognizable to immune cells;
  • “Hides” behind the cell membrane impenetrable to them.

Until now, all these features have made viruses virtually invulnerable to immune defenses and drugs. It is assumed that the appearance antiviral drugs reversed this trend. But there is no reliable data on whether this is actually the case.

How the medicine works

"Viferon" is a drug, which includes recombinant (synthesized by methods genetic engineering) immune agents interferons. It is released as:

  • gel;
  • ointments;
  • rectal suppositories.

Interferons are called proteins synthesized by the cell in response to the infection of the body with a virus. Their molecules are located on the surface of cell membranes and "catch" viruses trying to penetrate through them.

These proteins come in several forms (depending on which cells secrete them) and serve as a cellular self-defense mechanism against invading foreign DNA. With normally functioning immunity, in the first few days after infection, the number of interferons on the cell surface increases sharply, remains high for another one to two weeks, gradually decreasing to normal.

Preparations containing interferons presumably provide the same effect. This allows:

  • increase the resistance of cells to a viral infection faster;
  • increase it even if your own immunity fails;
  • ensure prevention by starting the drug before the expected infection.

Why caution is needed

The principles of the immune system, as well as the brain, have been studied by science by only 10-15%. Hence the impossibility of predicting how he will respond to “help” with interferons in difficult cases. For example, if the patient suffers from immunodeficiency, allergies, other immune disorders. In addition, the long-term side effects of the drug itself are not entirely clear - they have not yet been possible to observe.

There is also such a purely medical opinion that suppositories, tablets and ointments / gels / creams based on interferons are placebo. Not a single whole protein molecule can penetrate the skin or intestinal walls into the blood. The skin will not let it in under any circumstances, and during digestion (if taken in tablets), it will break down into amino acids, losing its special structure and purpose. It turns out that taking interferons makes sense only in the form of injections ...

When appointed

As always, when a new drug appears, parents have a question why they prescribe Viferon candles to children. Now it is already clear that Viferon candles are needed for a child as antiviral agent, and indications for their use are viral (not bacterial or fungal) infections, as well as diseases that cause immunodeficiency:

  • SARS;
  • flu;
  • viral hepatitis;
  • HIV and AIDS;
  • exacerbation of herpes;
  • diabetes;
  • pneumonia;
  • rotavirus infection;
  • chickenpox.

It is also believed that Viferon can be prescribed for chlamydia and trichomoniasis (both infections are caused by protozoa), recurrent candidiasis (fungal infection). It is often prescribed for sore throat, runny nose and other manifestations of acute respiratory infections.

The constant expansion of the circle of his appointments is facilitated by the fame attached to him. effective remedy to lower the temperature. In addition, parents (and doctors too) are stimulated to this by how quickly Viferon candles act. Really, high temperature they remove, on average, within the next half hour, and this effect lasts for about a day. And other symptoms of pathology are on the decline after an hour or two. However, the reviews of doctors about the results of the use of antipyretic suppositories "Viferon" for baby pretty restrained.

Possible risks

In the instructions for the use of candles "Viferon" for children, only one contraindication is indicated - that they should not be used in case of individual intolerance to any components in their composition.

Among the side effects of "Viferon" for an infant, only temporary allergic reactions are described, mainly in the form of urticaria. And cases of overdose, according to official information, have not yet been identified. Such a limited list negative effects may be equally likely related to the fact that:

  • the drug is still poorly understood;
  • it really does not penetrate the body in this form;
  • he is safe.

However, Viferon, like any other tool developed less than ten years ago, should not be considered safe just because the opposite is not indicated in the instructions for it. Therefore, it should not be used to treat easily occurring infections, as well as completely “non-core” cases - for example, from heat during teething.

Instructions for use and analogues of "Viferon" for children

Rectal suppositories "Viferon" may contain a different number of interferon molecules. Their minimum content in one suppository is 1,000,000 IU, the maximum is 500,000 IU. The only question is how to administer Viferon suppositories to a baby, especially a baby. The dosage of Viferon suppositories for young children is different in each case.

With viral and mixed pathologies of the upper respiratory tract

The assignments are:

  • children under seven years of age and slightly premature - one candle 150,000 IU every 12 hours for five days;
  • children over seven years of age"Adult" suppositories with a dosage of interferon 500,000 IU, according to the same scheme;
  • severely premature babies antiviral suppositories"Viferon" for children under one year old is administered one at a time (150,000 IU) every eight hours for five days in a row.

This is followed by a five-day break, and if the symptoms of the disease persist, the course can be repeated.

With systemic and generalized infections (including intrauterine)

The drug is used in the following doses:

  • meningitis - involves two courses of treatment for five days at a dosage of 150,000/500,000 IU every 8-12 hours (depending on the age of the child);
  • herpes - requires the appointment of two or three such courses;
  • fungal infections - two or three courses in combination with antifungal drugs.

The schedule of their treatment with "Viferon" in various age groups completely identical to that indicated in the previous paragraph. But given the scale and complexity of the process, such infections almost always require a second course.

For viral hepatitis

They are treated with "Viferon" at any age for at least six months. In this case, the drug is administered every 12 hours. For the first ten days, this is done daily, then every other day, at a dosage of:

  • children under the age of six months 300,000 IU per day;
  • children aged six months to one year 500,000 IU per day;
  • children aged 1 to 7 years at the rate of 3,000,000 IU of the active substance per m2 of body area per day;
  • children aged seven years and over at the rate of 5,000,000 IU of the active substance per m2 of body area per day.

Analogues

Currently, interferon-based drugs in Russia are already enough, and their range is constantly updated with new modifications. Among the most similar in composition and method of application of analogues:

  • "Alfarekin" - suppositories of Ukrainian production;
  • "Vitaferon" - suppositories of Ukrainian production;
  • "Laferobion" - suppositories of Ukrainian production;
  • "Laferon" - suppositories of Ukrainian production;
  • "Viferon-Feron" - suppositories produced in the Russian Federation;
  • "Genferon" - suppositories produced in the Russian Federation.

At the same time, one should not expect a significant difference in price from analogues of Viferon candles for a child compared to the original.

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If you have questions about the use of Viferon suppositories during pregnancy, see the article.
If you do not understand how to properly administer Viferon rectal suppositories, see the article.
Viferon price: in Moscow, Ukraine, Belarus.
O correct selection dosages of Viferon suppositories in questions and answers, read the article

Information on how to properly store Viferon candles in the form of questions and answers can be found in the article

Trade name of the medicinal product

Viferon (VIFERON)®

Manufacturer

Feron OOO, Russia

International non-proprietary name

Interferon human recombinant alpha-2

Dosage form

Suppositories rectal

Release form

Suppositories (150,000 IU, 500,000 IU, 1,000,000 IU, 3,000,000 IU) weighing from 0.95 g to 1.05 g, 10 pieces each in a PVC/paper blister pack or weighing from 1.00 g to 1.10 g, 10 pieces in blisters PVC/PVC. 1 or 2 blister packs with instructions for use in a cardboard pack

Description

The suppository has a bullet shape, yellowish-white color, uniform consistency. Color heterogeneity in the form of marbling and the presence of a funnel-shaped depression on the cut is allowed. The diameter of the suppository is not more than 10 mm.

Pharmacotherapeutic group

Immunomodulatory and antiviral agent.

Active substance

1 suppository VIFERON 150,000 IU contains the active substance - interferon human recombinant alpha-2 150,000 IU;
1 suppository VIFERON 500000 IU contains the active substance - interferon human recombinant alpha-2 500000 IU
1 suppository VIFERON 1000000 IU contains the active substance - interferon human recombinant alpha-2 1000000 IU
1 suppository VIFERON 3000000 IU contains the active substance - interferon human recombinant alpha-2 3000000 IU

Excipients

Ascorbic acid 0.015 g, alpha-tocopherol acetate 0.055 g, base cocoa butter or solid fat

pharmachologic effect

Interferon human recombinant alpha-2 has pronounced antiviral, immunomodulatory and antiproliferative properties. The complex composition of the drug determines the presence of a number of additional effects: in the presence of ascorbic acid and alpha-tocopherol acetate, the antiviral activity of human recombinant alpha-2 interferon increases, its immunomodulatory effect on T- and B-lymphocytes increases, the level of immunoglobulin E normalizes, and the functioning of the endogenous interferon system is restored. In addition, ascorbic acid and alpha-tocopherol acetate, being highly active antioxidants, have anti-inflammatory, membrane-stabilizing, and regenerating properties. It has been established that when using VIFERON there are no side effects that occur when parenteral administration interferon preparations, and antibodies are not formed that neutralize the antiviral activity of interferon.

Pharmacokinetics

After rectal administration after 12 hours, a decrease in serum concentration is observed, which necessitates its repeated administration.

Indications for use

In the complex therapy of various infectious and inflammatory diseases in children, including newborns and premature babies:

  • acute respiratory viral infections(influenza, SARS, including complicated bacterial infection),
  • pneumonia (bacterial, viral, chlamydial),
  • meningitis (bacterial, viral),
  • sepsis,
  • intrauterine infection (chlamydia, herpes, cytomegaly, enterovirus infection, candidiasis, including visceral, mycoplasmosis);
In complex therapy chronic viral hepatitis B, C, D in children and adults, including in combination with the use of plasmapheresis and hemosorption,
with chronic viral hepatitis of a pronounced degree of activity and complicated by cirrhosis of the liver;
in complex therapy in adults, including pregnant women, with urogenital infection(chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis),
primary or recurrent herpetic infection skin and mucous, localized form, mild and moderate course, including the urogenital form;
in complex therapy, including those complicated by a bacterial infection in adults.

Dosing regimen

Suppositories containing human recombinant alpha-2 interferon in the indicated dosages (150,000 IU, 500,000 IU, 1,000,000 IU, 3,000,000 IU) as an active substance are used rectally.
In the complex therapy of various infectious and inflammatory diseases in newborns, including premature: newborns, including premature babies with gestational age over 34 weeks appoint VIFERON 150,000 IU * daily, 1 suppository 2 times a day after 12 hours. The course of treatment is 5 days.
Preterm infants with gestational age less than 34 weeks appoint VIFERON 150,000 IU daily, 1 suppository 3 times a day after 8 hours. The course of treatment is 5 days.
The recommended number of courses for various infectious - inflammatory diseases at children, including newborns and premature:

  • influenza, SARS, including those complicated by a bacterial infection - 1-2 courses;
  • pneumonia(bacterial, viral, chlamydial) - 1-2 courses,
  • sepsis- 2-3 courses,
  • meningitis- 1-2 courses,
  • herpetic infection– 2 courses,
  • enterovirus infection- 1-2 courses,
  • cytomegalovirus infection - 2-3 courses,
  • mycoplasmosis, candidiasis, including visceral, - 2-3 courses.
The break between courses is 5 days. By clinical indications therapy may be continued.

In complex therapy chronic viral hepatitis B, C, D in children and adults: for children with chronic viral hepatitis, the drug is prescribed in the following age dosages: up to 6 months 300,000-500,000 IU per day; 6 to 12 months- 500,000 IU per day. Aged from 1 year to 7 years- 3,000,000 IU per 1 m2 of body surface area per day. Aged over 7 years old- 5,000,000 IU per 1 m2 of body surface area per day. for each individual patient is produced by multiplying the recommended for given age dosage per body surface area calculated from nomogram to calculate the body surface area in height and weight according to Harford, Terry and Rourke, divided into 2 injections, rounded up to the dosage of the appropriate suppository. The drug is used 2 times a day after 12 hours for the first 10 days daily, more three times a week every other day for 6-12 months.
The duration of treatment is determined clinical efficacy and laboratory indicators. Children with chronic viral hepatitis with a pronounced degree of activity and liver cirrhosis before the plasmapheresis and/or hemosorption indicated the use of the drug for 14 days daily, 1 suppository 2 times a day after 12 hours(for children under 7 years old VIFERON 150,000 IU, for children over 7 years old - VIFERON 500,000 IU).
Adults with chronic viral hepatitis appoint VIFERON 3000000 IU 1 suppository 2 times a day after 12 hours for 10 days daily, then three times a week every other day for 6-12 months. The duration of treatment is determined by clinical efficacy and laboratory parameters.
In complex therapy, adults, including pregnant women, With urogenital infection(chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis), with primary or recurrent herpetic infection skin and mucous membranes (localized form, mild and moderate course, including urogenital form).
Adults, with the above infections, except for herpes, are prescribed Viferon 500000 IU on 1 suppository 2 times a day after 12 hours. The course is 5-10 days. According to clinical indications, therapy can be continued with intervals between courses of 5 days.
At herpetic infection appoint VIFERON 1000000 IU 1 suppository 2 times a day after 12 hours. The course of treatment is 10 days or more with recurrent infection. It is recommended to start treatment immediately when the first signs of skin and mucous membrane lesions (itching, burning, redness) appear. In the treatment of recurrent herpes, it is advisable to start treatment at prodromal period or at the very beginning of the manifestation of signs of relapse.
At pregnant women with urogenital infection, including herpetic, in the II trimester of pregnancy (starting from the 14th week) - Viferon 500,000 IU 1 suppository every 12 hours (2 times a day) for 10 days, then 1 suppository every 12 hours (2 times a day) twice a week - 10 days. Then, after 4 weeks, preventive courses of the drug Viferon are carried out. 150,000 IU 1 suppository every 12 hours - for 5 days, the prophylactic course is repeated every 4 weeks. If necessary, it is possible to treatment course before childbirth.

Separate article. In complex therapy influenza and other acute respiratory infections viral diseases , including those complicated by bacterial infection in adults. Apply VIFERON 500000 IU 1 suppository 2 times a day every 12 hours daily. The course of treatment is 5-10 days.

Contraindications

Hypersensitivity to any of the components of the drug

Pregnancy and lactation

The drug is approved for use from the 14th week of pregnancy. It has no restrictions for use during lactation.

Side effect

In rare cases, it is possible to develop allergic reactions(skin rash, itching). These phenomena are reversible and disappear 72 hours after discontinuation of the drug.

special instructions

Can be used as part of combination therapy With antibacterial drugs, GKS, immunosuppressive drugs, interferon inducers.

Overdose

Data not provided

drug interaction

VIFERON, rectal suppositories, compatible and well combined with all drugs used in the treatment of the above diseases (antibiotics, chemotherapy drugs, glucocorticosteroids)

Best before date

2 years. Do not use the drug after the expiration date

Storage conditions

In a place protected from light, at a temperature of 2 to 8 ° C. Transportation and storage in accordance with SP 3.3.2.1248-03 at a temperature of 2 to 8 ° C. Store out of the reach of children

Terms of dispensing from pharmacies

Without a doctor's prescription

approximate price

Russia: 150,000 IU $5.3-7, 500,000 IU $7.9-9.5, 1,000,000 IU $10.9-13.8, 3,000,000 IU $18.7-21.1
Belarus: 150,000 IU $10-14.3, 500,000 IU $13.9-19.4

Release form: Solid dosage forms. Suppositories are rectal.



General characteristics. Compound:

Active substance: 150,000 IU, 500,000 IU, 1,000,000 IU, or 3,000,000 IU human recombinant interferon alfa-2b.

Excipients: alpha-tocopherol acetate, ascorbic acid, sodium ascorbate, disodium edetate dihydrate, polysorbate-80, cocoa butter base and confectionery fat.


Pharmacological properties:

Pharmacodynamics. Interferon alpha-2b human recombinant has immunomodulatory, antiviral, antiproliferative properties. The immunomodulatory properties of interferon, such as increased phagocytic activity of macrophages, increased specific cytotoxicity of lymphocytes to target cells, determine its mediated antibacterial activity.

In the presence of ascorbic acid and alpha-tocopherol acetate, the specific antiviral activity of interferon increases, its immunomodulatory effect increases, which makes it possible to increase the effectiveness of the body's own immune response to pathogenic microorganisms. When using the drug, the level of class A secretory immunoglobulins increases, the level of immunoglobulin E normalizes, and the functioning of the endogenous interferon system is restored. Ascorbic acid and alpha-tocopherol acetate, being highly active antioxidants, have anti-inflammatory, membrane-stabilizing, and regenerating properties. It has been established that when using Viferon, there are no side effects that occur with the parenteral administration of interferon preparations, no antibodies are formed that neutralize the antiviral activity of interferon.

The use of the drug allows to reduce the therapeutic doses of antibacterial and hormonal drugs, as well as reduce the toxic effects of this therapy.

Cocoa butter contains phospholipids, which make it possible not to use synthetic toxic emulsifiers in production, but the presence of polyunsaturated fatty acids facilitates the administration and dissolution of the drug.

Indications for use:

- acute respiratory viral infections, including those complicated by a bacterial infection (bacterial, viral, chlamydial) in children and adults as part of complex therapy;
- infectious and inflammatory diseases of newborns, including premature babies: (bacterial, viral), (chlamydia, herpes, candidiasis, including visceral, mycoplasmosis) as part of complex therapy;
- chronic viral hepatitis B, C, D in children and adults as part of complex therapy, including in combination with the use and in chronic viral hepatitis of severe activity, complicated by cirrhosis of the liver;
- infectious and inflammatory diseases of the urogenital tract (chlamydia, cytomegalovirus infection, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis) in adults as part of complex therapy;
- primary or recurrent herpetic infection of the skin and mucous membranes, localized form, mild and moderate course, including the urogenital form in adults.


Important! Get to know the treatment

Dosage and administration:

The drug is used rectally. 1 suppository contains human recombinant interferon alfa-2b as an active substance in the indicated dosages (150,000 IU, 500,000 IU, 1,000,000 IU, 3,000,000 IU).

Acute respiratory viral infections, including influenza, including those complicated by a bacterial infection, pneumonia (bacterial, viral, chlamydial) in children and adults as part of complex therapy.The recommended dose for adults, including pregnant women and children over 7 years of age, is VIFERON® 500,000 IU, 1 suppository 2 times a day every 12 hours every day for 5 days. According to clinical indications, therapy can be continued.

Children under 7 years of age, including newborns and premature babies with a gestational age of more than 34 weeks, are recommended to use the drugVIFERON® 150,000 IU 1 suppository 2 times a day every 12 hours daily for 5 days. According to clinical indications, therapy can be continued. The break between courses is 5 days.

For premature newborns with a gestational age of less than 34 weeks, the use of VIFERON® 150,000 IU is recommended.1 suppository 3 times a day after 8 hours daily for 5 days.According to clinical indications, therapy can be continued. The break between courses is 5 days.

Infectious and inflammatory diseases of newborns, including premature infants: meningitis (bacterial, viral), sepsis, intrauterine infection (chlamydia, herpes, cytomegalovirus infection, enterovirus infection, candidiasis, including visceral, mycoplasmosis) as part of complex therapy.The recommended dose for newborns, including premature babies with a gestational age of more than 34 weeks, is VIFERON® 150,000 IU daily, 1 suppository 2 times a day after 12 hours. The course of treatment is 5 days.

Premature newborns with a gestational age of less than 34 weeks are recommended to use the drug VIFERON® 150,000 IU daily, 1 suppository 3 times a day after 8 hours. The course of treatment is 5 days.

The recommended number of courses for various infectious and inflammatory diseases: sepsis - 2-3 courses, meningitis - 1-2 courses, herpes infection - 2 courses, enterovirus infection - 1-2 courses, cytomegalovirus infection - 2-3 courses, mycoplasmosis, candidiasis, including visceral — 2-3 courses. The break between courses is 5 days. According to clinical indications, therapy can be continued.

Chronic viral hepatitis B, C, D in children and adults as part of complex therapy, including in combination with the use of plasmapheresis and hemosorption in chronic viral hepatitis of severe activity, complicated by liver cirrhosis.The recommended dose for adults is VIFERON® 3,000,000 IU, 1 suppository 2 times a day every 12 hours daily for 10 days, then three times a week every other day for 6-12 months. The duration of treatment is determined by clinical efficacy and laboratory parameters.

Children aged 1 to 7 years are recommended 3,000,000 IU per 1 m2 of body surface area per day.

The drug is used 2 times a day after 12 hours for the first 10 days daily, then three times a week every other day for 6-12 months. The duration of treatment is determined by clinical efficacy and laboratory parameters.

Calculation daily dose The drug for each patient is produced by multiplying the recommended dose for a given age by the body surface area calculated from the nomogram to calculate the body surface area by height and weight according to Harford, Terry and Rourke. The calculation of a single dose is carried out by dividing the calculated daily dose by 2 injections, the resulting value is rounded up to the suppository dosage up.

In chronic viral hepatitis of severe activity and liver cirrhosis, before plasmapheresis and / or hemosorption, it is recommended to use VIFERON® 150,000 IU for children under 7 years of age, VIFERON® 500,000 IU for children over 7 years of age, 1 suppository 2 times a day after 12 hours daily within 14 days.

Infectious and inflammatory diseases of the urogenital tract (chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardnerellosis, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis) in adults, including pregnant women as part of complex therapy.The recommended dose for adults is VIFERON® 500,000 IU, 1 suppository 2 times a day every 12 hours daily for 5-10 days. According to clinical indications, therapy can be continued.

2 times a day after 12 hours daily for 10 days, then for 9 days 3 times with an interval of 3 days (on the fourth day) 1 suppository 2 times a day after 12 hours. Then every 4 weeks until delivery VIFERON® 150,000 IU1 suppository 2 times a day after 12 hours daily for 5 days.

If necessary, it is indicated before delivery (from 38 weeks of gestation) the use of the drug VIFERON® 500,000 IU, 1 suppository 2 times a day after 12 hours daily for 10 days.

Primary or recurrent herpetic infection of the skin and mucous membranes, localized form, mild and moderate course, including the urogenital form in adults, including pregnant women.The recommended dose for adults is VIFERON® 1,000,000 IU, 1 suppository 2 times a day every 12 hours every day for 10 days or more in case of recurrent infection. According to clinical indications, therapy can be continued. It is recommended to start treatment immediately when the first signs of skin and mucous membrane lesions (itching, burning, redness) appear.

In the treatment of recurrent herpes, it is desirable to begin treatment in the prodromal period or at the very beginning of the manifestation of signs of relapse.

Pregnant women from the II trimester of pregnancy (starting from the 14th week of gestation) are recommended to use the drug VIFERON® 500,000 IU, 1 suppository2 times a day after 12 hours daily for 10 days, then for 9 days 3 times with an interval of 3 days (on the fourth day) 1 suppository 2 times a day after 12 hours. Then every 4 weeks until delivery VIFERON® 150000 IU 1 suppository 2 times a day after 12 hours daily for 5 days. If necessary, it is indicated before delivery (from 38 weeks of gestation) the use of the drug VIFERON® 500,000 IU, 1 suppository 2 times a day after 12 hours daily for 10 days.

Dosing regimen

Week of gestation*

Application scheme

From the 14th week of gestation VIFERON® 500,000 IU 1 suppository 2 times a day for 10 days. Then VIFERON® 500,000 IU 1 suppository 2 times a day after 3 days, 3 times for 9 days.

Step 1.
C + C (morning/evening)
VIFERON® 500,000 IU

Step 2
C + C (morning/evening)
VIFERON® 150,000 IU

20, 24

28, 32

36, 40

From 38 weeks of gestation to delivery VIFERON® 500,000 IU 1 suppository 2 times a day for 10 days.

C + C (morning/evening)
VIFERON® 500,000 IU

Application Features:

Impact on ability to drive vehicles and engage in other activities. Not installed.

Use during pregnancy and during breastfeeding: The drug is approved for use from the 14th week of pregnancy. Has no restrictions for use during breastfeeding.

Side effects:

In rare cases, the development of allergic reactions (skin rashes, itching) is possible. These phenomena are reversible and disappear 72 hours after discontinuation of the drug.

Interaction with other drugs:

VIFERON®, rectal suppositories, is compatible and well combined with all drugs used in the treatment of the above diseases (antibiotics, chemotherapy drugs, glucocorticosteroids).

Contraindications:

Hypersensitivity to any of the components of the drug.

Overdose:

Not installed.

Storage conditions:

At a temperature of 2 to 8 ° C, in a place protected from light. Keep out of the reach of children. Shelf life - 2 years. Do not use the drug after the expiration date.

Leave conditions:

Without recipe

Package:

Rectal suppositories 150000 IU, 500000 IU, 1000000 IU, 3000000 IU. 5 or 10 suppositories in PVC/PVC blisters. 1 blister pack of 10 suppositories or 2 blister packs of 5 suppositories with instructions for use in a cardboard pack.