Hormonal ointment for the oral mucosa. Adhesive ointment for the treatment of lesions of the oral mucosa in lichen planus

I. Painkillers

Primarily for the treatment of a child with acute and recurrent herpetic stomatitis, in order to remove or weaken painful symptoms in the oral cavity, an affordable and very effective anesthetic is used - anesthesin ointment for lubricating the oral mucosa before meals and treating the oral cavity.

II. Specific antiviral agents for topical therapy

Bonafton ointment - 0.5%. Antiviral activity is manifested in the effect on the reproduction of HSV. Lubricate the mucous membrane of the mouth 3-4 times a day after meals.

Tebrofen ointment - 0.25 and 0.5%. It has an antiviral effect due to the ability to inhibit the growth of viruses. The ointment is effective in the treatment of acute and recurrent herpetic stomatitis, and also acts against the influenza virus and adeno viral infection. It is recommended to lubricate the mucous membrane 3-4 times a day.

Florenal ointment - 0.5%. Provides high neutralizing activity against HSV. Irritant action does not affect the mucous membrane; lubricate the mucous membrane 2-4 times a day.

Adima ointment- 0.5%. It has a high neutralizing activity against the influenza virus and HSV.

DNase - 1% solution that has the ability to prevent intracellular reproduction of DNA-containing viruses. Produced in vials of 25-50 mg. The contents must be dissolved before use in 5 ml isotonic solution sodium chloride.

Oxolinic ointment - 0.25%. The most widely used antiviral ointment. The virucidal effect of the ointment is especially pronounced in relation to the influenza virus, adenovirus, to a lesser extent - to HSV.

Riodoxol ointment - 0.25 and 0.5%. Provides antiviral and antifungal action, has virus-neutralizing activity against influenza and herpes viruses. With possible side effects (burning, hyperemia of the mucous membrane), the drug is canceled. Lubricate the mucous membrane thin layer 1-3 times a day.

Alpizorin ointment - 2.5%; alpizarin liniment - 5%. It has high activity against DNA-containing viruses. For the treatment of affected areas of the skin, 5% alpizarin ointment is used, with lesions of the oral mucosa - 2% ointment applied 4-6 times a day. The drug is characterized by good absorption, anti-inflammatory action, high chemotherapeutic index. It has immunostimulatory properties against cellular immunity. Compared with bonafton, alpizarin is less toxic.

Gossypol - 3% liniment. It has an antiviral effect, weakly active against gram-positive microorganisms. Gossypol liniment is available in jars of 20 g. The drug is well tolerated.

Megosin ointment - 5%. It is a drug synthesized from gossypol, has virucidal activity against HSV, an interferon inducer, the drug has proven itself in the treatment of recurrent herpetic stomatitis.

interferon preparations. Interferon in ampoules of 500 IU/ml actively suppresses the reproduction of most known viruses, which prevents the development infectious process. Characterized by harmlessness, absence of side effects and allergic reactions. It is used in the treatment and prevention of acute and recurrent herpetic stomatitis, viral warts in children.

Aqueous solution of leukocyte human interferon for instillation into the nasal cavity and mouth - 3-5 drops per day after meals.

Vinylin-based interferon ointment is prepared according to the prescription: interferon - 2.0 x 10 IU / g; anestezin - 0.1; vinylin - 10.0. Stir thoroughly before use. Indications for the use of interferon ointment are all forms of viral infection in children.

Zovirax (acyclovir) acts selectively on cells infected with HSV, and on the DNA polymerase of viruses. It has low toxicity to cells that are not infected with the virus. It has an immunostimulating property, has an anti-relapse effect. It is used for herpetic stomatitis, ophthalmic herpes in the form of a 3% ointment on a soft paraffin base, for herpes lips in the form of a 5% cream on a white water creamy base. The drug is applied 5 times a day for 5 days. Treatment is recommended to start in the prodromal period.

Drugs that stimulate interferon formation in the body. One of the most simple ways is UFO.

Poludan has the ability to stimulate the production of endogenous interferon, has an antiviral effect. Used as eye drops. The contents of the ampoule (0.0002 g) must be dissolved in 2 ml of distilled water and instilled 6-8 times a day.

III. Medications for local symptomatic action

Antiseptic treatment of the oral mucosa is indicated for advanced and severe forms disease and precedes use antiviral drugs. In dentistry, antimicrobial agents are widely used for antiseptic treatment. These include: 1% solution of sanguirythrin; 0.5% solution of ethonium; 0.5% solution of sodium mefenaminate, etc. New aerosol preparations have antiseptic, anti-inflammatory, analgesic effects. However, their use in children is not always desirable due to the freon content, cooling effect, possible allergic reactions, and also because of the fright that they often cause in babies.

Ambassador The composition includes propolis, which has anti-inflammatory, disinfectant, analgesic and antiviral properties. Should be used in the absence of allergies to bee products.

Cameton - aerosol combination drug containing chlorobutanol hydrate, camphor, menthol, eucalyptus, vaseline oil and freon.

Devovinizole consists of chloramphenicol, vinylin, linetol, citral and ethyl alcohol. Has antibiotic properties a wide range- chloramphenicol and anti-inflammatory properties of its constituent components. Contraindicated in case of intolerance to chloramphenicol and microflora resistance to it.

livian - anti-inflammatory, disinfectant and keratoplastic drug having a combined composition (linetol, anestezin, etc.).

IV. Proteolytic Enzymes

They have pronounced antiseptic and proteolytic properties. In addition to the main necrolytic action, enzymes enhance and restore the phagocytic activity of neutrophilic leukocytes and fibroblasts, which contributes to the rapid flow of regeneration processes. For effective cleansing trypsin, chymotrypsin, chymopsin, solutions of DNase, Ronidase, terrilitin, hygrolithin are applied to the affected mucous membrane from necrotic masses.

trypsin - a proteolytic enzyme that has a pronounced anti-inflammatory effect. Produced in ampoules containing 0.01 and 0.005 g of trypsin. The contents of the ampoule are dissolved before use in 5 ml of distilled water.

Chymotrypsin - proteolytic enzyme of the pancreas. It is similar in action to trypsin and has the same indications for use. Available in ampoules of 0.01 and 0.005 g. The contents of the ampoule are dissolved in 5 ml of isotonic sodium chloride solution.

V. Keratoplastic agents

During the onset of epithelialization, keratoplastic substances are prescribed that accelerate the healing processes of the elements of the lesion. From symptomatic remedies that promote epithelialization, use a 1% oil solution of citral, rosehip oil, aloe ointment, carotoline, an oil solution of vitamin A, solcoseryl (jelly and ointment), as well as alazol and inosol aerosols. All preparations are applied in the form of applications 3-4 times a day.

Solcoseryl - a combined preparation consisting of solcoseryl, polidocanol and the base of the ointment. The action of the ointment is based on the ability to activate fibrinolysin, accelerate the growth of fibroblasts, increase energy metabolism in tissues and reduce swelling. Produced in the form of ointment and jelly for lubrication of the mucous membrane.

Rosehip oil, sea ​​buckthorn oil, carotolin and an oily solution of vitamin A - used for applications and lubrication of the mucous membrane.

VI. Preparations general therapy Preparations of general specific and non-specific antiviral and immune therapy.

Bonafton - tablets of 0.1 and 0.25 g; taken orally, without chewing, one hour after eating, 1 (0.25 g) table. 5 times a day; course of treatment 5 days. The drug is most effective when used in combination with local antiviral agents. Possible side effects: headache, dyspepsia.

Alpizarin is available in the form of tablets of 0.1 g. The drug is well absorbed, exhibits antiviral activity due to its inhibitory effect on the reproduction of HSV, has a high immunotherapeutic index, and stimulates cellular immunity. The use of the drug from the first days of the disease gives a positive therapeutic effect.

Alpizarin tablets are taken orally, regardless of the meal. Adults are prescribed 0.1 g, the course of treatment is 10-15 days; children - 1/2 tab. 3 times a day for 7 days. It is recommended to use in combination with local treatment.

Zovirax (acyclovir) has a pronounced antiherpetic activity. Effective in patients with herpes with immune deficiency of various origins. Zovirax for internal administration is available in vials containing 250 mg of sterile acyclovir. The solution must be prepared immediately before use by adding 10 ml of isotonic sodium chloride solution. The dose for children is calculated on the body surface area in accordance with the instructions for use of the drug.

Interferon has an inhibitory effect on a wide range of viruses. Mechanism antiviral action It consists in its penetration into the cell, followed by the synthesis of an antiviral protein, which prevents or suppresses the reproduction of viruses.

It is used as an anti-relapse agent. It has no contraindications, is available in ampoules of 500 IU / ml. Method of application: intramuscularly, 1 ml every 3-4 days, course - 4-5 injections.

Reaferon - domestic drug used for the treatment of various viral diseases: hepatitis B, influenza and its complications, ophthalmic herpes and genital herpes. Treatment with reaferon in cases of virus infection in children is carried out according to the following scheme: intramuscular injection 500,000 IU 1 time per day. Course - 5 injections with an interval of 1-2 days. After the 1st course of therapy in case of repeated recurrence and the absence of a tendency to improve the condition within 5-6 months. a second course is prescribed according to the same scheme.

After treatment with reaferon, most children have a positive therapeutic effect. Children tolerate the drug well side effects and allergic reactions are not observed. With a continuously relapsing form of herpetic stomatitis in children for 1-2 months. there is a gradual decrease in the severity of symptoms of a general and local nature, up to complete disappearance. Reaferon helps to interrupt the permanent course of the disease, increase remission, in some cases - to clinical recovery.

Decaris (levamisole) selectively stimulates the regulation of the function of T-lymphocytes, plays the role of an immunomodulator, enhancing the response of cellular immunity. In the treatment of children with recurrent herpetic stomatitis, it helps to prevent relapses. Assign children 50 mg after meals once on the recommendation of a pediatrician. Side effects with a single application are not observed. Taken in the form of tablets, 1/2 tab. per day for 3 days with a break of 5 days between cycles. In total, the course of treatment is 2-3 cycles.

The invention relates to the pharmaceutical industry, namely to an agent for the treatment of lesions of the oral mucosa with red lichen planus. Adhesive ointment for the treatment of lesions of the oral mucosa with lichen planus, containing sea buckthorn oil and 0.5% prednisolone ointment, solcoseryl dental adhesive paste and vitamin A, at a certain ratio of components. The above ointment is effective for the treatment of lesions of the oral mucosa with lichen planus. 3 Ave.

The invention relates to the field of clinical medicine, namely to dermatology and dentistry, and can be used to treat the oral mucosa in patients with lichen planus.

Red lichen planus(ICD-10 code: L43) is a chronic pruritic dermatosis of a multifactorial nature, characterized by monoform papular rashes on the skin and mucous membranes.

The lesion of the mucous membrane of the mouth and lips is characterized by the appearance of small nodules, the size of a pinhead, flat polygonal, dense, grayish-white in color with a sheen. The mucosa is most commonly affected inner surface cheeks and tongue. Eating and speaking become difficult specific smell from mouth.

Local treatment for lesions of the oral mucosa (OM) is the use of ointments using corticosteroids. In addition, in the clinic, in the treatment of lesions of the oral mucosa with lichen planus, rinses with antiseptics and local anesthetics, applications with keratoplastic agents: sea buckthorn oil, rosehip oil.

A known method for the treatment of lichen planus (LP) of the oral mucosa (patent invention RU 2356551 C1 dated March 17, 2008). To do this, Mexidol is used in tablets and in the form of Mexidol dent fito toothpaste. Mexidol tablets are administered one twice a day for a month. toothpaste use twice a day for 1-1.5 months. EFFECT: invention makes it possible to increase the effectiveness of treatment and lengthen the period of remission due to the general and local influence of mexidol on the pathogenesis of the disease.

Also known is a method of treating lichen planus by complex therapy with the use of desensitizing agents, local application to the oral mucosa of a hormonal and keratoplastic agent of 4% water-insoluble colloidal solution of chitosan with a degree of deacetylation of 0.95 molecular weight 100-120 kD, which is applied to the pre-treated with a 1% hydrogen peroxide solution and dried oral mucosa in the affected areas with a thin layer 3 times a day after meals 1 time at night for 30 days, after which for prophylaxis for another 30 days continue treatment with a solution of chitosan 1 time per day after meals and 1 time at night (patent for invention RU 2258516 C1).

A known method for the treatment of lichen planus of the oral mucosa using vitamins A, E, C, multivitamins as for general treatment, and for local (applications of oil solutions of vitamins A, E, carotenoline, rosehip oil, sea buckthorn, etc.) in order to normalize metabolic processes in the body and the epithelium of the oral mucosa.

However, this therapy is applicable only in the typical form of lichen planus, it does not take into account the peculiarities of the healing process of the affected oral mucosa in exudative-hyperemic and erosive-ulcerative forms of LP. In addition, there is a known method local treatment KPL SOPR with the use of corticosteroid ointments (sinalar, flucinar - "drugs that regulate metabolic processes, refer to the hormones of the adrenal cortex and to their synthetic analogues”), stimulating drugs (methyluracil - “drugs that stimulate metabolic processes”), and carotolin (“vitamins and related drugs, a drug of the carotene group”) was used as a keratoplastic drug.

This method of treatment has a pronounced anti-inflammatory effect and stimulates reparative processes in the oral mucosa.

However long-term use hormonal ointments can cause side effect in the form of atrophy of the epithelium, inhibition of regeneration processes, there are contraindications for use in viral infections. Stimulant and epithelizing preparations have weak adhesion to the oral mucosa and do not suppress the associated secondary infection.

Some authors note good wound healing effect when using vitamin A for the treatment of lesions of the oral mucosa in LP, the regulation of the processes of proliferation and differentiation of epithelial cells, but weak adhesion can be considered a disadvantage of the method oil solution vitamin A to ORM, lack of antibacterial action, which leads to an increase in the duration of treatment and can lead to possible relapses diseases.

The closest in technical essence and selected as a prototype is an ointment consisting of 2 components: sea buckthorn oil and 0.5% prednisolone ointment. However, the ointment applied to the mucous membrane is also easily washed off with saliva and food, so its anti-inflammatory and keratoplastic effect does not have a stable therapeutic effect, leading to accelerated healing. erosive lesions mucous membrane.

The task was to create an ointment for the treatment of lesions of the oral mucosa with lichen planus, which has a high adhesive, keratoplastic and anti-inflammatory effect.

EFFECT: increased efficiency of treatment of lesions of the oral mucosa in LP by reducing the time of epithelialization of the affected mucosa when using the claimed ointment, which combines high adhesive, keratoplastic and anti-inflammatory activity of its components.

The task is achieved by using an ointment containing sea buckthorn oil and 0.5% prednisolone ointment, solcoseryl dental adhesive paste, vitamin A, with the following % ratio of components:

The inventive ointment for the treatment of lesions of the oral mucosa in LP is prepared as follows. All the necessary components are prepared in the prescribed amount and mixed at room temperature.

For 100 g of the finished product it is necessary: ​​to 20 g of sea buckthorn oil add

20 g of 0.5% prednisolone ointment, mix thoroughly. 40 g of solcoseryl dental adhesive paste and 20 g of vitamin A are added to the resulting composition. Mix thoroughly until a homogeneous mass is formed.

Characteristics of the components of the claimed ointment.

Sea buckthorn oil provides a keratoplastic effect due to the content of essential macro- and microelements, including vitamins E, C, B1, B2, B6, F, P, folic acid, flavonoids (rutin), tannins, normalizes local metabolism.

0.5% prednisolone ointment has anti-inflammatory, anti-allergic and anti-exudative effects.

Solcoseryl dental adhesive paste (Reg. No. 015194/01-2003) provides accelerated healing, pain relief and protection of the wound surface. In addition, the paste provides high adhesion (sticking) of the medicinal components introduced into the composition to the wet mucous membrane, and, as a result, guarantees a long-term deposition of all medicinal components of the ointment in the mucous membrane, which is necessary to stimulate the processes of regeneration, anesthesia, sorption and healing.

Vitamin A (retinol) - fat-soluble vitamin, antioxidant, participates in redox processes, regulation of protein synthesis, promotes normal metabolism, functions of cell and subcellular membranes, plays important role in the formation of bones and teeth, as well as body fat; needed for new cell growth.

The parameters of the components introduced into the composition of the proposed agent were determined empirically. The introduction of components below the lower or above the upper limits does not provide optimal impact, and also worsens the presentation.

The shelf life of the resulting ointment is 1 month. The parameters of the ointment are stable during storage. The ointment is a light yellow mass with a pleasant smell.

The technical result of the proposed solution is achieved by a combination of high adhesive, keratoplastic, anti-inflammatory and sorption activity of the components.

Therapeutic action of the proposed agent has been tested in the clinic. Complications, allergic reactions and side effects when using this ointment were not identified. The ointment is well fixed on the mucosa, even in the presence of saliva and exudate, providing long-term deposition medicinal substances on the surface of mucosal lesions, reduces the time of epithelialization of the oral mucosa.

The claimed ointment has passed clinical trials on the basis of the State Budgetary Institution "Regional Clinical venereal dispensary» Stavropol.

Examples of specific implementation.

Example 1. Patient A., 65 years old, amb. card number 1719.

Complaints of pain when eating. Objectively: on the buccal mucosa there are multiple papular elements, grayish-white in color, merging, form a mesh pattern, the mucosa is hyperimposed, painful when eating.

Diagnosis: widespread lichen planus, typical form, exudative-hypermic on the oral mucosa, was made on the basis of complaints, anamnesis, objective biopsy data. The patient received a traditional course of therapy with oral administration of stimulants (sodium nucleinate) and desensitizing agents (tavegil) and local application of hormonal drugs (sinalar) to the oral mucosa.

Treatment. For the treatment of lesions of the oral mucosa, the patient was prescribed the claimed adhesive ointment - applied 2-3 times a day to the damaged areas of the mucous membrane.

Immediately after the start of the application of the ointment, its high adhesive and keratoplastic effect was noted. After a single application, the ointment is fixed on the mucosa even after eating. The epithelialization of the affected mucosal mucosa has accelerated significantly, food intake and speech are facilitated, the patient indicates an improvement in the general condition.

On examination on the 3rd day, there is a decrease in inflammatory foci, pain persists when taking hot food, on the 5th day the mucous membrane is painless, pale pink, moist, on the 14th day there are single papular rashes, on the 21st day the papules are preserved only in the retromolar region. A month after the end of treatment, the patient does not complain, the mucous membrane of the oral cavity is pale pink, moist, along the line of closing of the teeth there are single papules without signs of inflammation, flattened.

Example 2. Patient S., 45 years old, amb. card number 1975.

The patient was admitted with a diagnosis of widespread lichen planus, a typical form on the oral mucosa. The diagnosis was made on the basis of complaints, anamnesis, objective biopsy data and contact microscopy. The patient received a traditional course of general therapy with oral stimulant (sodium nucleinate) and desensitizing (tavegil) agents.

Against the background of general therapy, the patient was prescribed the inventive ointment for the treatment of lesions of the oral mucosa - apply 2-3 times a day to the damaged areas of the oral mucosa.

Epithelialization of erosions accelerated significantly, especially pronounced was healing effect in the retromolar region, where the deepest foci were located, eating and speech were significantly facilitated, already 3 days after the start of treatment, the patient indicated an improvement in her general condition.

On examination on the 5th day, the presence of inflammatory foci was noted, the pain persists when taking hot food, on the 7th day the mucous membrane is painful, hyperimposed in the area of ​​papular elements, on the 14th day papular rashes persist, on the 21st day inflammation decreases, papules are preserved. A month after the end of treatment, the patient complains of discomfort in the oral cavity, the mucous membrane of the oral cavity is pale pink, moist, along the line of closing of the teeth, there are single papules without signs of inflammation.

Example 3. Patient S., 45 years old, amb. card No. 12247 (according to the "prototype" method).

The patient was admitted with a diagnosis of lichen planus, a typical form on the oral mucosa. The diagnosis was made on the basis of the patient's complaints, collected medical history, objective biopsy data and contact microscopy. The patient received a traditional course of general therapy with oral stimulants (sodium nucleinate) and desensitizing agents (tavegil).

Against the background of general therapy, the patient was prescribed a prototype ointment for the treatment of lesions of the oral mucosa.

The effect of the local treatment was significantly lower than when using the developed ointment. The main disadvantage of the prototype ointment was that the applied ointment was easily washed off with saliva and food, so its anti-inflammatory and keratoplastic effect did not have a stable therapeutic effect, and the healing of mucosal lesions did not accelerate. Ointment prototype did not provide keratoplastic effect, the patient constantly complained of pain when eating and talking.

After 35 days of treatment against the background of complete disappearance clinical manifestations Papules continued to persist on the skin and in the oral cavity, which led to an increase in the duration of treatment up to 60 days.

Clinical trials of the proposed ointment were carried out in 46 patients in the period from 2009 to 2011. on the basis of GBUZ "Regional clinical venereal dispensary" Stavropol. None of the patients who used the claimed ointment for the treatment of lesions of the oral mucosa in LP, inflammatory complications was not noted, and the terms of epithelialization of erosions, on average, decreased by 50%. The high keratoplastic and anti-inflammatory effect of the developed ointment was especially pronounced due to its high adhesion to the oral mucosa.

The obtained data showed high adhesive, keratoplastic and anti-inflammatory properties of the developed ointment, allowing to accelerate the healing of the oral mucosa, prevent the development of inflammatory complications and reduce the period of complete epithelialization of the affected mucosa in LP, which allows us to recommend more wide application this ointment in the clinic.

Thus, the proposed technical solution allows to obtain an inexpensive, cost-effective highly effective remedy for the treatment of lesions of the oral mucosa in lichen planus, as well as to reduce the treatment time.

CLAIM

Adhesive ointment for the treatment of lesions of the oral mucosa with lichen planus, containing sea buckthorn oil and 0.5% prednisolone ointment, characterized in that it additionally contains solcoseryl dental adhesive paste and vitamin A in the following ratio of components, %.

It is an intensive growth and recovery stimulant normal structure body tissues. That is why it is used very widely - in any industry where it is required to accelerate tissue repair or enhance cell growth - from the healing of postoperative sutures to the recruitment muscle mass. For ease of use, Methyluracil is available in several forms that act systemically, topically and externally.

Forms of release and composition

In addition to these three forms, Methyluracil ointment with Miramistin is produced in Ukraine, which contains an antiseptic, so the drug is similar in its action to Levomekol.

Methyluracil ointment is available in aluminum tubes with a volume of 25 g. The tablets are packed in convolutes and are sold in 50 or 100 pieces. Candles Methyluracil are available in packs of 10 pieces. And the Ukrainian ointment Methyluracil with Miramistin is sold in aluminum tubes of 15 and 30 grams.

Ointment, tablets and suppositories contain as active ingredient substance methyluracil, which gave the commercial name to the drug. The ointment contains methyluracil in the amount of 100 mg per 1 g (10%), one tablet and a suppository - 500 mg each active ingredient. Ukrainian Methyluracil with Miramistin contains methyluracil 500 mg per 1 g, and antiseptic Miramistin - 50 mg per 1 g of ointment. As auxiliary components, ointments and suppositories contain alcohols, paraffins and macrogol, and tablets - potato starch. These components need to be known so that people suffering from it can adequately assess whether they can take the drug without fear.

Therapeutic action and effects

Stimulation with methyluracil intensive recovery process on the cellular level leads to production a large number protein in the body that athletes use to gain muscle mass. In sports circles, methyluracil is considered an anabolic substance that accelerates muscle growth and weight gain.

In addition, methyluracil has a strong anti-inflammatory effect, and has a photoprotective effect when applied to the skin.

Indications for use

Methyluracil - instructions for use

Methyluracil tablets

• Adults and adolescents from the age of 14 take Methyluracil 1 tablet (500 mg), 4 to 6 times a day.
• Children from 3 to 8 years old take half a tablet (250 mg), 3 times a day.
• Children from 8 to 14 years old take half or a whole tablet (250 mg or 500 mg), 3 times a day.

The duration of the course of therapy for organ damage digestive system(stomach and duodenum, peptic ulcer, enteritis, etc.) is 30-40 days. Therapy of diseases gastrointestinal tract is the longest. Therefore, in the treatment of other pathologies, Methyluracil tablets are used in shorter courses, the duration of which is determined by the rate of recovery and the normalization of a person's well-being.

Methyluracil ointment

Methyluracil can be applied to any wound surface to accelerate the recovery of normal tissue structures. To do this, first, the seam, wound or burn is treated with antiseptic solutions - washed with 3% hydrogen peroxide, furatsilin, potassium permanganate, chlorhexidine, 70% alcohol, etc. When processing, all purulent and necrotic masses are thoroughly washed out of the wound. Intact skin around the wound or suture is also treated. After that, an ointment is applied directly to the wound surface, to the seam, to the cut, to the burn, which is covered with sterile gauze on top. If the wound is actively cleaned, there is a lot of pus, exudate or necrotic tissue in it, then such treatment with the application of a new bandage is carried out every 4 hours. If the wound is clean, then it is optimal to treat and apply a new dressing twice a day - in the morning and in the evening. The duration of the application of the ointment depends on the rate of restoration of the normal structure of the tissue. Usually postoperative suture under the influence of Methyluracil heals within 4-5 days.

Women use Methyluracil to accelerate the healing of the vaginal mucosa and perineal sutures after childbirth. Seams must be properly processed, following the following sequence of actions:
1. Wash with soap.
2. Wash the seams with an antiseptic solution (potassium permanganate, furatsilin, hydrogen peroxide, etc.).
3. Dry the skin gently with a soft, clean cloth.
4. Lie on the bed without wearing underwear, and dry the skin of the perineum in the air for 15 minutes.
5. Squeeze methyluracil ointment onto sterile gauze and apply it to the sutures.
6. Wear clean, natural lined underwear.
7. Depending on the number of lochia, change gauze with ointment after 2 to 6 hours.

Methyluracil ointment is also used to heal microcracks and ruptures of the vaginal mucosa after childbirth. Women inject the ointment into the vagina in two main ways. Before administering the drug, you should wash yourself vaginally and douche with a weak solution of potassium permanganate. After that, dry the perineum with a soft and clean cloth. Then insert the ointment into the vagina with a finger or a swab. If a woman can squeeze a little ointment onto her finger, insert it into the vagina and lubricate the mucosa in a circular motion, then this option can be used. Otherwise, apply about 5 cm of ointment to a cotton swab and insert it into the vagina. It is necessary to use Methyluracil in this way 2-3 times a day, until the mucous membrane heals and the woman feels normal (usually this interval is 4-7 days).

Many women cannot insert a tampon with ointment into the vagina - it is smeared, drains, etc. To facilitate the introduction, it is necessary to lie on your back, spread your legs bent at the knees, and raise the pelvis, remaining in this position for 2 to 3 minutes. After a while the muscles pelvic floor relax, and the tampon can be easily inserted, remaining in the described position.

Methyluracil suppositories

• 500 - 1000 mg (1 - 2 suppositories), 3 - 4 times a day for adults;
• 250 mg (half a candle) per day for children from 3 to 8 years old;
• 500 mg (1 suppository) per day for children from 8 to 14 years old.

Before inserting the suppository into the rectum, a bowel movement should be performed. To reduce possible pain in the process of defecation, it is recommended to call it with an oil enema. For this 15 - 20 ml vegetable oil(sunflower, olive, etc.) are collected in a small rubber bulb. The tip of the pear is also oiled and inserted into the anus. By pressing on the main part of the pear, the oil is injected into the rectum. After a while, the urge to defecate will appear, which cannot be ignored. The process of defecation on an oil enema will be relatively easy, since the feces, smeared with oil, will quickly slip through the rectal sphincter, causing little to no pain.

After that, the anus must be washed with water and dried with a soft, clean cloth. Take a comfortable position, wet the finger with which you are going to insert the candle into the anus. Take one candle, and with a finger moistened with water, insert deep into the rectum. Wash your hands after the procedure. Then you need to put on clean underwear, which is not a pity to get dirty, since a small amount of the composition of the candles, having melted inside the rectum, can flow out. After the introduction of the suppository, you must lie down quietly for half an hour.

Methyluracil vaginally. Gynecologists have long used Methyluracil suppositories to accelerate the repair of the vagina and cervix in women. To heal cervical erosion, methyluracil suppositories are administered vaginally twice a day (morning and evening), for 10 to 14 days. For the purpose of treating colpitis or vulvitis, suppositories, depending on the severity of the condition, are administered 1 to 2 times a day, for 10 days. Well vaginal application candles Methyluracil can be from 8 to 30 days, depending on the initial condition and the speed of recovery.

Before inserting a suppository into the vagina, it is necessary to douche with solutions baking soda, chlorhexidine, nitrofural, or infusions of string and chamomile. After douching, insert the suppository deep into the vagina and put on clean underwear that you don’t mind getting dirty. This is due to the fact that the suppository in the vagina melts and flows out a little. After the introduction of the suppository into the vagina, it is necessary to lie down in bed for about half an hour.

Methyluracil with Miramistin - instructions for use

Ointment treatment is carried out once a day. As the wound heals, the number of treatments decreases to 1 time in 2 days. The duration of application is determined by the dynamics of recovery and the extent of the lesion. The use of Methyluracil ointment with Miramistin is stopped when the wound is cleared and the first signs of healing appear.

Application during pregnancy

In the presence of erosion of the cervix, it is possible to reduce its area with the help of Methyluracil suppositories, regularly undergoing a course of therapy for. This approach is practiced in many European countries so that the cervix for childbirth is as close to normal as possible.

Also, pregnant women can apply ointment to any wounds on the surface of the skin so that they heal faster, without leaving marks and without being at risk of infection.

Treatment with Methyluracil

Haemorrhoids

With hemorrhoids, you can use Methyluracil in the form of an ointment or suppositories. Candles are inserted deep into the rectum, and the ointment is applied to the finger, which is used to lubricate the mucous and hemorrhoids. Candles are conveniently used for localization of hemorrhoids in the rectum. And the ointment is preferable for hemorrhoids that protrude outward. Methyluracil for the treatment of hemorrhoids is used on average 7-14 days, depending on the severity of the disease and the speed of recovery.

Before the introduction of suppositories or applying ointment, it is necessary to empty the intestines. Wash the perineum and area after defecation anus water and dry with a soft, clean cloth. Insert a candle deep into the rectum, then lie quietly in bed for 30 minutes. The suppository will melt in the rectum, so a small amount of the contents may leak out. When using the ointment, it is necessary to squeeze a small amount of the composition from the tube onto the finger, and lubricate the hemorrhoids from the outside. Then squeeze out a little more ointment and shallowly insert a finger into the anus, lubricating the walls of the intestine in a circular motion.

Gynecological diseases

Although Methyluracil suppositories are rectal, they can be safely inserted into the vagina. Doctors in practice have long and successfully used Methyluracil much more widely than stated in the manufacturer's instructions. This is due to the fact that suppositories were developed to treat certain pathologies (sigmoiditis, proctitis, etc.). However therapeutic properties The drug proved to be effective not only for the treatment of diseases of the rectum, which determined its use in gynecology. But the instruction is issued old, it does not make changes that the scope of Methyluracil has undergone over time.

During treatment gynecological diseases candles Methyluracil must observe sexual rest. Candles are inserted into the vagina twice a day (morning and evening) to treat cervical erosion, or after cauterization, to speed up the restoration of normal tissue structure. The duration of application is on average 10 - 14 days. With colpitis, vulvitis, as well as after removal of the uterus or operations on the female genital organs, suppositories are administered 1 to 2 times a day. In this case, the treatment of colpitis and vulvitis is limited to the use of the drug for 10 days. And to accelerate tissue recovery after surgery, Methyluracil suppositories are used for a longer period of time - from 14 to 30 days, depending on the amount of intervention.

Before the introduction of suppositories into the vagina, it is necessary to remove mucus by douching, which is carried out with solutions of baking soda, chlorhexidine, nitrofural, or decoctions of chamomile and string.

After surgery, women can apply Methyluracil ointment to the stitches to speed up their healing and reduce scarring. Thus, the use of an ointment for a suture after a cesarean section leads to a significant decrease in its thickness and severity. Women successfully use the ointment to accelerate the healing of sutures in the perineum after childbirth or gynecological operations. Methyluracil also perfectly restores the structure of the vaginal mucosa after radiation therapy.

Noteworthy is the method of using Methyluracil for the prevention of ruptures of the vaginal mucosa and perineal skin during childbirth. To do this, the ointment is applied to the skin of the perineum and vaginal mucosa (on a swab) twice a day for 10 days before the expected date of delivery - in the morning and in the evening. Such preventive preparation reduces the risk of ruptured labor by 50-70%. This technique is accepted in many obstetric institutions of the countries of Eastern Europe.

• allergic reactions
• Burning sensation that goes away on its own
• mild itching

Analogues

• Actinolysate solution is administered intramuscularly;
• Tablets Anaferon;
• Tablets Arpetolid;
• Vitanam tablets;
• Wobenzym tablets;
• Vobe-mugos tablets;
• Tablets Gerbion echinacea;
• Tablets Immunorm;
• Imudon tablets;
• Tablets Neuroferon;
• Phlogenzym tablets;
• Estifan tablets;
• Tablets Engystol;
• Drops Florexil;
• Syrup Bioaron;
• Syrup Immunex;
• Capsules Isofon;
• Capsule Turbosan;
• Capsule Uro-Vaksom;
• Tablets, suppositories and powder Galavit;
• Glutoxim solution, injected;
• Desoxinate solution, injected;
• Molixan solution is administered intravenously and intramuscularly;
• Erbisol solution;
• Solution and lyophilizate Gepon;
• Zadaxin lyophilizate, injected subcutaneously;
• Elixir Echinocor;
• Solution, liniment, tablets, lyophilisate