Lazolvan reception. Preparations with similar composition

Mucolytic and expectorant drug

Active substance

Ambroxol hydrochloride (ambroxol)

Release form, composition and packaging

◊ Solution for oral administration and inhalation transparent, colorless or slightly brownish.

Excipients: citric acid monohydrate - 2 mg, sodium hydrogen phosphate dihydrate - 4.35 mg, - 6.22 mg, benzalkonium chloride - 225 mcg, purified water - 989.705 mg.

100 ml - amber glass bottles (1) with a polyethylene dropper and a polypropylene screw cap with first opening control, complete with a measuring cup - cardboard packs.

pharmachologic effect

Studies have shown that the active ingredient of the drug Lazolvan increases secretion in the respiratory tract. Strengthens products pulmonary surfactant and stimulates ciliary activity. These effects lead to increased mucus flow and transport (mucociliary clearance). Increasing mucociliary clearance improves sputum discharge and relieves cough.

In patients with COPD, long-term drug therapy (for at least 2 months) led to a significant reduction in the number of exacerbations. There was a significant decrease in the duration of exacerbations and the number of days of antibiotic therapy.

Pharmacokinetics

Suction

All immediate-release dosage forms of ambroxol are characterized by rapid and almost complete absorption with a linear dose dependence in the therapeutic concentration range. Cmax when taken orally is achieved within 1-2.5 hours.

Distribution

V d is 552 l. In the therapeutic concentration range, protein binding is approximately 90%. The transition of ambroxol from blood to tissues during oral administration happens quickly. Highest concentrations active component of the drug are observed in the lungs.

Metabolism

Approximately 30% of the dose taken orally undergoes a first-pass effect through the liver. Studies on human liver microsomes have shown that CYP3A4 is the predominant isoform responsible for the metabolism of ambroxol to dibromoantranilic acid. The remainder of ambroxol is metabolized in the liver, mainly by glucuronidation and by partial breakdown to dibromanthranilic acid (approximately 10% of the administered dose), as well as a small number of additional metabolites.

Removal

The terminal half-life of ambroxol is about 10 hours. The total clearance is within 660 ml/min, renal clearance accounts for approximately 8% of the total clearance. Using the radioactive tracer injection method, it was estimated that after taking a single dose of the drug, about 83% of the dose taken is excreted in the urine over the next 5 days.

Pharmacokinetics special groups patients

No clinically significant effect of age and gender on the pharmacokinetics of ambroxol was found, so there is no basis for selecting the dose based on these characteristics.

Indications

Spicy and chronic diseases respiratory tract accompanied by the release of viscous sputum and impaired mucociliary clearance:

- spicy and Chronical bronchitis;

- pneumonia;

- difficulty with sputum discharge;

- bronchiectasis.

Contraindications

— increased sensitivity to ambroxol or other components of the drug;

— I trimester of pregnancy;

- period of lactation (breastfeeding).

Carefully Lazolvan should be used during pregnancy (II and III trimesters), with renal and/or liver failure.

Dosage

Oral administration (1 ml = 25 drops).

Drops can be diluted in water, tea, juice or milk. The solution can be used regardless of meals.

Adults and children over 12 years old- 4 ml (100 drops) 3 times/day; children aged 6 to 12 years- 2 ml (50 drops) 2-3 times/day; children aged 2 to 6 years- 1 ml (25 drops) 3 times/day; children under 2 years of age- 1 ml (25 drops) 2 times/day.

Inhalations

Adults and children over 6 years old- 1-2 inhalations of 2-3 ml of solution/day.

Children under 6 years of age- 1-2 inhalations of 2 ml solution/day.

Lazolvan solution for inhalation can be used using any modern equipment for inhalation (except steam inhalers). To achieve optimal hydration during inhalation, the drug is mixed with 0.9% sodium chloride solution in a 1:1 ratio. Since when inhalation therapy Taking a deep breath can provoke a cough; inhalation should be carried out in normal breathing mode. Before inhalation it is usually recommended to warm up inhalation solution to body temperature. Patients with bronchial asthma It is recommended to carry out inhalation after taking bronchodilators, in order to avoid nonspecific irritation of the respiratory tract and their spasm.

If symptoms of the disease persist within 4-5 days from the start of using the drug, it is recommended to consult a doctor.

Side effects

From the outside digestive system: often (1-10%) – dysgeusia (violation taste sensations), nausea, decreased sensitivity in the mouth or throat; infrequently (0.1-1%) - dyspepsia, vomiting, diarrhea, abdominal pain, dry mouth; rarely (0.01-0.1%) – dry throat.

For the skin and subcutaneous tissues: rarely (0.01-0.1%) – rash, itching*.

Allergic reactions: rarely (0.01-0.1%) – urticaria; anaphylactic reactions(including anaphylactic shock)*, angioedema*, hypersensitivity*.

* these adverse reactions were observed with widespread use drug; with 95% probability data frequency adverse reactions– infrequently (0.1%-1%), but possibly lower; the exact frequency is difficult to estimate, because they were not noted in clinical studies.

Overdose

Specific symptoms of overdose in humans have not been described.

There have been reports of accidental overdose and/or medical error resulting in symptoms known side effects of the drug Lazolvan: nausea, dyspepsia, vomiting, diarrhea, abdominal pain.

Treatment: provocation of vomiting, gastric lavage in the first 1-2 hours after taking the drug, symptomatic therapy.

Drug interactions

No clinically significant, undesirable interactions with other drugs have been reported.

Ambroxol increases the penetration of amoxicillin, cefuroxime, and erythromycin into the bronchial secretions.

special instructions

Should not be used in combination with antitussives that impede the removal of sputum.

The solution contains a preservative, which, when inhaled, may cause bronchospasm in sensitive patients with increased respiratory tract reactivity.

Lazolvan solution for oral administration and inhalation is not recommended to be mixed with cromoglycic acid and alkaline solutions. An increase in the pH value of the solution above 6.3 may cause precipitation of ambroxol hydrochloride or the appearance of opalescence.

For patients on a diet with reduced content sodium, it is necessary to take into account that Lazolvan solution for oral administration and inhalation contains 42.8 mg of sodium in the recommended daily dose(12 ml) for adults and children over 12 years old.

There are isolated reports of severe lesions skin (Stevens-Johnson syndrome and toxic epidermal necrolysis), which coincided with the use of expectorants such as ambroxol hydrochloride. In most cases, they are explained by the severity of the underlying disease and/or concomitant therapy. In patients with Stevens-Johnson syndrome or toxic epidermal necrolysis in early phase fever, body pain, rhinitis, cough, etc. may appear. At symptomatic treatment Possible erroneous prescription of anti-cold medications. If new lesions of the skin and mucous membranes develop, the patient should stop treatment with ambroxol and immediately seek medical help.

If renal function is impaired, Lazolvan should be used only on the recommendation of a doctor.

Impact on ability to manage vehicles and mechanisms

There were no cases of the drug influencing the ability to drive vehicles and machinery. Studies on the effect of the drug on the ability to drive vehicles and engage in other potentially dangerous species activities requiring increased concentration attention and speed of psychomotor reactions were not carried out.

Pregnancy and lactation

Ambroxol penetrates the placental barrier. Preclinical studies have not revealed direct or indirect adverse effects on pregnancy, embryonic/fetal, postnatal development and labor.

Extensive clinical experience with the use of ambroxol after the 28th week of pregnancy has not found evidence of a negative effect of the drug on the fetus. However, the usual precautions should be taken when using the drug during pregnancy. It is especially not recommended to take Lazolvan in the first trimester of pregnancy. In the second and third trimesters of pregnancy, the use of the drug is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

No clinically significant effect of age on the pharmacokinetics of ambroxol was found, so there is no basis for selecting the dose based on these characteristics.

Conditions for dispensing from pharmacies

The drug is available without a prescription.

Storage conditions and periods

The drug should be stored in its original packaging out of the reach of children at a temperature not exceeding 25°C. Shelf life - 5 years.

For diseases respiratory system with characteristic wheezing in the bronchi and unproductive cough justified therapeutic use medication Lazolvan (solution), which has secretolytic and expectorant properties.

Thanks to the active component of the drug, secretion in the respiratory tract increases, and increased production of bronchial surfactant helps stimulate the motility of the ciliated epithelium. All this leads to easier evacuation of mucus from respiratory organs, their purification (called mucociliary clearance).

In contact with

Since before consuming any medication, even if it is sold over-the-counter, you need to read the instructions for use and consider the most important provisions of this document.

Composition of Lazolvan solution

According to the instructions, the active component of Lazolvan solution is the mucolytic Ambroxol. The instructions also provide a list of additional components that provide the medicine with a sour-salty-bitter taste, which is not too pronounced when dissolved with water or other liquid.

The solution is made in the form of a transparent substance of varying brownish tones, poured into glass containers with a polymer dropper. In addition to the bottle, instructions for using Lazolvan oral solution and a measuring cup are included.

In what cases is it used?

The drug Lazolvan (solution) is recommended for oral administration in acute or chronic course diseases of the respiratory system characterized by the production of viscous sputum:

bronchiectasis;
with weak sputum secretion;
in or .

Due to the activation of pulmonary secretion clearance and improved sputum evacuation, coughing is also relieved. With prolonged COPD treatment(at least 8 weeks in a row) it is possible to significantly reduce the frequency of exacerbations of the disease.

Is it possible to use Lazolvan solution to treat children? Instructions for use for children from the first year of life recommend using the medication in small doses.

Instructions for oral use

Before you start using the medication, you should find out how to take Lazolvan (solution), in what doses and for how long. This information contains information about the drug Lazolvan and instructions for use of the solution for oral administration in children and adults.

Dosage

The bottle with the medication is equipped with a dropper and a container with a measure, which makes it easier to use Lazolvan oral solution according to the dosage suggested in the instructions. The manufacturer of the drug indicates the following dosages of Lazolvan solution for children in the instructions for use:

for children under 2 years of age - 25 drops twice a day;
preschoolers under 6 years old - 25 drops three times a day;
children under 12 years of age - 50 drops three times a day.

How to give?

Eat serious reason discuss the issue of how to give Lazolvan (solution) to children with your pediatrician. According to the instructions, the solution should be diluted with a small amount of water, milk, tea or juice.

A pediatrician who knows about your child’s tendency to allergic reactions (for example, diathesis) and other characteristics will advise in which liquid it is better to dilute mucolytic drops.

How to take for adults?

What does the leaflet say about how to take Lazolvan (solution) for adults? For adult patients and children over 12 years of age, a single dosage of the drug Lazolvan is established. Instructions for use of the oral solution for adults and children over 12 years of age suggest taking 100 drops of the medication three times a day.

special instructions

As in the first case, the drops should be diluted in water or other liquid. This medicine is not associated with food intake. In any document attached to medication special instructions As a guide, there is a section “ ", where situations are considered in which the use of medication should be carried out with caution, or other important points

. But first, let's talk about contraindications, since this factor must be taken into account before starting therapy with the mucolytic drug Lazolvan. It is prohibited for use:
pregnant women in the first trimester;
mothers who are breastfeeding;

people with increased sensitivity to ambroxol. Patients with slow metabolism medicines due to liver failure or decreased excretory function

kidneys, as well as women in the II-III trimesters of pregnancy, the drug should be used carefully, that is, carefully monitoring the reaction to its use. If undesirable effects occur, use of the drug will have to be stopped.

Abstract for the use of the drug Lazolvan does not recommend combining its use with the use of antitussives that suppress the cough reflex.

It should also not be mixed with alkaline solutions (for example, soda water) or cromglycic acid (membrane stabilizing, antiallergic agent). The instructions draw the attention of patients following a hyposodium diet (with salt restriction) that the daily adult dose

The drug (12 ml) contains 42.8 mg of sodium. The use of the drug Lazolvan (solution) can increase the symptoms of dangerous- toxic epidermal necrolysis and Steven-Johnson syndrome. If new foci of skin lesions occur while taking the drug, you should stop using it and consult a doctor.

Lazolvan should be used with caution and only in consultation with a doctor in patients with impaired renal function.

Patient reviews

Before purchasing a medication, many patients try to study reviews of this medicine from those who have already taken it. It would also be useful to find out how consumers evaluate Lazolvan solution. Reviews about the medicine provide a fairly objective picture of its effectiveness.

The majority of respondents speak of Lazolvan as effective drug against dry cough or sticky cough. Moreover, patients positively evaluate this particular dosage form - Lazolvan solution, since its effect manifests itself faster and more effectively than when treated with tablets.
The solution is very convenient to give to children, however, many parents called its bitter taste a disadvantage.
Another drawback - high price for the drug, which recently increased. However, there are also patients who believe that the inflated cost of the medication is compensated by its efficiency - the drops last for a long time, and healing effect comes quickly.

Other forms of the drug

Invented and patented in Germany, produced by an Italian pharmaceutical company, it has several dosage forms:

solution;
syrup;
extended-release capsules;
pills.

For inhalation procedures Lazolvan is used in the form of a solution, the description of which is presented above. The instructions for use of the solution contain separate instructions for using this form of Lazolvan as an inhaled substance. It can be used in any type of inhaler, except steam. Methods for diluting the solution and carrying out the procedure are described in the instructions for Lazolvan and for operating the inhaler.

The active substance of Lazolvan syrup is also ambroxol hydrochloride; the list of auxiliary components is somewhat wider and includes sorbitol. Instructions for use draw attention to this fact Special attention those patients who have a rare hereditary pathology - fructose intolerance. Such patients are contraindicated to take Lazolvan syrup.

Pharmacology does not know a separate drug for Lazolvan called “syrup for children”. The syrup described above is recommended for use in children from the first year of life, and the instructions for use describe the dosage of using the syrup in children depending on age.

Another form of Lazolvan is tablets; they are preferred by people who, due to the characteristics of their body, cannot drink syrup. Or those who find it more convenient to swallow a tablet rather than count the required number of drops of solution.

Judging by the reviews, the tablets are not as fast-acting as Lazolvan in the form of syrup or solution, but their use provides a lasting therapeutic effect. Most often, tablets (or sustained-release capsules) are chosen as a medication for long-term treatment of COPD.

Useful video

From the following video you will learn:

Conclusion

Lazolvan (solution) is an effective, fast-acting medication with mucolytic and expectorant properties.
The use of Lazolvan solution is advisable for diseases of the respiratory system, accompanied by the release of scanty viscous sputum.
Depending on personal preferences or the age of the patient, you can choose any of the four dosage forms of the drug. The medicine is over-the-counter, but consulting a doctor before starting treatment is always advisable.

For diseases of the respiratory system that occur with the release of viscous mucus, mucolytic agents are used to stimulate the discharge of sputum.

Lazolvan syrup is a mucolytic: the instructions for use recommend drinking it when respiratory diseases, at which it is observed.

In contact with

Composition of Lazolvan syrup

is a drug that has several forms - lozenges, tablets, inhalation solution and syrup. They are based active substance Ambroxol is an expectorant.

Ambroxol hydrochloride has secretolytic and secretomotor properties: it first increases the amount of secretion from the respiratory tract, and then stimulates its release (expectoration).

The auxiliary components of Lazolvan syrup include benzoic acid, glycerol, water, hyaetellose, flavorings and liquid sorbitol. The drug does not contain sugar, so it can be taken by diabetics.

On sale Lazolvan cough syrup can be found in wild berry and strawberry flavors. The medicine is released in a glass bottle containing 15 or 30 mg of ambroxol per 5 ml of sweet solution.

Indications for use

You can take drugs according to the instructions for use for diseases of the respiratory organs, accompanied by a wet cough with complicated sputum production:

asthma;
chronic pulmonary obstruction;
cold.

Instructions for use for cough

Lazolvan cough syrup instructions for use recommend taking it orally for 4–5 days. During this period of time, the symptoms of the disease are expected to ease.

How to use?

How to take Lazolvan syrup for adults? According to the instructions for use, you need to drink it:

10 ml three times a day is adult dosage, acceptable for patients over 12 years of age;
children over 6 years old should take 5 ml 2-3 times a day;
patients over 2 years old can take the medicine 2.5 ml three times a day;
Children under 2 years old are allowed to take 2.5 ml twice a day.

Before or after meals?

When is it better to take Lazolvan cough syrup - before or after meals? The instructions for use clearly indicate: regardless of food. You can take the medicine before meals, as well as some time after meals in the morning, lunch or evening.

special instructions

Special instructions in the instructions for use - how to take Lazolvan syrup - refer to possible side effects while taking the drug, as well as contraindications. You should not take the medicine if:

pregnancy and breastfeeding;
hypersensitivity to the components of the drug;
renal failure;
liver dysfunction.

Despite the fact that the manufacturer in the instructions for use allows taking the drug from the second trimester, it is recommended to refrain from taking it throughout pregnancy.

The ability of ambroxol to penetrate the placental barrier has been proven. Although there is no specified data on the pathogenic effects of the substance on the fetus, the risk of negative effects still remains.

In the instructions for use, we also do not recommend drinking Ambroxol while breastfeeding, since the substance also passes into mother's breast milk.

Can it be used for dry cough?

The instructions for use do not allow Lazolvan syrup for dry coughs, since drugs of a different principle of action are used for this type of cough. The instructions for use do not contain instructions on how to take Lazolvan syrup for dry cough in adults and children.

Since the principle of action of Lazolvan is to reduce the viscosity of sputum and remove it out during a cold, it makes no sense to drink this medicine if you have a dry cough.

Reviews

Reviews about Lazolvan cough syrup are mostly positive. Patients positively evaluate the possibility of taking it by both adults and children. While other cough medicines have age restrictions for use, the drug can be taken by children under 2 years of age. Reviews describe Lazolvan syrup as an easy-to-take medicine that has a sweet berry flavor.

Unlike drugs plant based, ambroxol shows a pronounced therapeutic effect, while herbal-based drugs for the treatment of acute respiratory viral infections have, for the most part, a mild deodorizing and emollient effect.

Analogs

If you need to use drugs based on another active ingredient, you can look for an analogue of Lazolvan syrup among medicines plant origin. Medicines that have the same pharmacological action, can be called analogues.

Lazolvan has them as follows:

Marshmallow syrup;
(primrose root extract and thyme herb);
Dr. Theiss with plantain;
Licorice root syrup and others.

These medicines have a significant difference from Lazolvan: they are based on medicinal plants, while the drug contains the synthetic substance ambroxol. Other drugs with this substance are called synonyms, and this group includes:

Ambroxol (Republic of Belarus);
(Germany);
(Hungary);
Ambroxol Vramed (Bulgaria).

Other forms of the drug

Other forms of medication are also intended for accelerated elimination sputum from the bronchi.

Solution for internal reception and inhalation of 7.5 mg/ml ambroxol in 100 ml bottles with a measuring cup (manufacturer: Instituto De Angeli).

Lazolvan for children is synonymous with the usual Lazolvan a, but with a reduced dosage - 15 mg/5 ml (manufactured by Boehringer Ingelheim Espana, Spain or Delpharm Reims, France).

Which is better - syrup or tablets?

All drugs for internal use act the same, regardless of the form in which the active substance is located. Therefore, the question of which is better - Lazolvan syrup or tablets - is subjective. The first one is better suited for children who like sweet taste berries The tablets provide the same therapeutic effect, but they contain 162.5 mg of lactose, which is not suitable for people with lactase deficiency. In another form of the drug there is no sugar, and sorbitol gives the sweet taste and viscosity, which can be taken by people with diabetes.

But there is also a strong argument in favor of tablets: treatment with their help is cheaper, because a bottle of medicine lasts a maximum of 3-4 days, and a pack of tablets is used up within 7-8 days.

Useful video

For more information on treating cough in adults, watch the following video:

Conclusion

Lazolvan syrup for adults and children - effective remedy against wet cough, which facilitates the release of sputum and shortens the period of taking antibiotics and other drugs for respiratory diseases.
The medicine can be taken by children from 2 years old at 2.5 mg twice a day or use the form of the children's drug Lazolvan.
The medicine is not used for dry cough, because in this case drugs of a different principle of action must be used.
There is no need to take Lazolvan during pregnancy and lactation, as well as hypersensitivity to ambroxol.

When buying a medicine, we want this drug to be not only effective, but also safe, that is, one that could be given to children. Lazolvan is just such a drug that helps with coughs, promoting the separation of sputum. The developers of the drug have provided several different forms drug so that both adults and children can take it.

The instructions for using the drug and the reviews of those people who shared their personal experience. But all this is only a secondary aspect, and the primary factor in the choice therapeutic drug is the recommendation of the attending physician.

Lazolvan: instructions for use syrup for children (official)

Forms of Lazolvan for children under 12 years old

A child can take no more than 30-45 mg of medication per day. Usually three doses of the drug are prescribed per duck.

Syrup Lazolvan

The medicine is sold in a concentration of 15 mg of the active substance per 5 ml of the drug and 30 ml per 5 mg.

The drug with a concentration of 15 mg is called children's and can be prescribed to children under 6 years of age. Dosages for the treatment of children:

0.5 tsp each (2.5 ml) 2 times a day for children under 2 years of age;
0.5 tsp each (2.5 ml) 3 times a day for children from 2 to 6 years old;
1 tsp (5 ml) 3 times a day for children from 6 to 12 years old.

The drug with a concentration of 30 ml is not prescribed to children under 6 years of age. Dosages:

0.5 tsp (2.5 ml) 3 times a day for children from 6 to 12 years old.

Lazolvan for inhalation

Prescribed for debilitating dry cough during colds(ARI, ARVI).

1 glass bottle contains 2 ml of inhalation solution, which contains 15 mg of active substance.

If inhalations are carried out 2-3 times a day, then you should not use additional lazolvan in the form of tablets or syrup. If only once, then you can supplement the treatment with others dosage forms drug.

Inhalations can be used by children over 5 years of age and adults during colds accompanied by a sharp dry cough.

Instructions for use (dosage):

for the treatment of children under 2 years of age, it is recommended to use 1 ml of solution for inhalation;
for the treatment of children aged 2 to 5 years, it is recommended to use 2 ml of solution for inhalation;
For the treatment of children over 5 years of age, it is recommended to use 3-4 ml of solution for inhalation.

Lazolvan solution

The solution can be given to children. Until the age of 2, the solution is given to children 2 times a day, 1 ml. From 2 to 6 years old, it is prescribed to take 1 ml three times a day. From 6 to 12 years of age, the medicine is taken 2 ml 2-3 times a day. The number of doses per day and dosage are best agreed with your doctor.

Pastilles

1 lozenge contains 15 mg of ambroxol. Lozenges should be dissolved. Children's dose - from 6 years old, 1 piece 2-3 times a day.

inflammatory processes in the respiratory system;
infectious diseases of the respiratory tract.

It is used to treat pneumonia and bronchitis, to alleviate the condition of obstructive bronchitis And .

Premature babies are often born with an underdeveloped respiratory system, which is called respiratory distress syndrome. Due to the property of the active substance to activate the production of surfactant (a liquid that protects lung tissue) in the lungs, it is effectively used to treat premature babies.

Forms of the drug

Regular pharmacies sell:

in a glass bottle dark color 100 ml solution;
ampoules for injection (15 mg/2 ml, 2 ml ampoules, 10 pieces per pack);
tablets (1 tablet contains 30 mg of ambroxol; packaged in blisters of 10 pieces);
syrup (concentration of 15 and 30 mg of ambroxol in 5 mg of the drug)
Lazolvan solution for oral administration and inhalation
nasal spray - lazolvan rino.

Lazolvan for children is presented in the form of a colorless syrup with a pleasant fruity taste (raspberry, citrus or apricot). Also children's drug– Lazolvan solution for inhalation.

Active substance

The main active ingredient of lazolvan is ambroxol, which has good penetrating ability. The effect of the medicine begins 20-30 minutes after it enters the human body and lasts for 8-12 hours.

The active substance is well excreted by the body and does not accumulate in it.

Effect of the drug

For dry cough and difficulty clearing the throat, the medicine helps to thin the mucus and remove it.

Improves the penetration ability of antibiotics accompanying treatment, such as erythromycin, gentamicin, while promoting the effect of drugs on the site of inflammation. What is the price of the drugs and the price depends on the form of release of the drug?

Price depending on shape

The price of the solution for inhalation is 360-440 rubles.

The price of tablets is from 260 rubles (30 mg x20).

The price of lazolvan in lozenges is from 240 rubles (15 mg No. 20). You can also find it for 170.

Syrup price: concentration 15 mg - from 250 rubles, 30 mg - from 280 rubles.

The price of a nasal spray is 260-300 rubles.

Release forms of Lazolvan for adults

An adult can consume from 90 to 120 mg of the drug per day. Usually three doses of the drug are prescribed per day.

Syrup

A tasty substance containing 15 mg of active substance in 5 ml of the drug is prescribed to children over 12 years of age and adults 10 ml three times a day.

Pills

They are usually prescribed to adults and children over 12 years of age, 1 tablet three times a day for the first 2 days. On the third day, the medicine is taken 2 times a day until the symptoms become less severe.

Then you can reduce the dose to 0.5 tablets, which you drink 3 times a day. It is recommended to drink the medicine until the cough completely disappears.

Lazolvan rino spray is used to relieve nasal congestion during:

colds (acute respiratory infections, acute respiratory viral infections);
sinusitis;
, seasonal allergic rhinoconjunctivitis.

Lazolvan Rino aerosol constricts the vessels located in the nasal mucosa, which helps relieve swelling of its tissues and congestion.

Instructions for use of Lazolvan Rino

Lazolvan rino spray can be used by adults and children over 12 years of age 4 times a day for no more than 7 days.

The injection is carried out in each nasal passage, after cleaning the nose.

atrophic rhinitis;
angle-closure glaucoma;
intolerance to the components of the spray.

You cannot use Lazolvan Rino spray in the first trimester of pregnancy.

People who had to endure surgery nose, you should not use Lazolvan Rino spray. You can easily pick up others enough effective analogues, which even cost less.

Lazolvan lozenges

1 lozenge contains 15 mg of active ingredient.

The lozenge is slowly dissolved in the mouth. It is permissible to dissolve 2 lozenges 3 times a day. The drug is taken between meals.

Solution for oral administration and inhalation

The solution is used not only for inhalation, but it is also prescribed for oral administration.

Note: 1 ml solution = 25 drops

The solution is taken regardless of diet. It can be added to water, tea, juice and even milk.

Children over 12 years of age and adults take 4 ml of solution three times a day.

Lazolvan for injection

The injection is performed intravenously or in the form of a dropper. The dosage should not exceed 30 mg/kg body weight. The drug is administered 4 times a day. The injection is done very slowly, the duration of drug administration should be at least 5 minutes.

You can administer the drug using a dropper.

Side effects and contraindications

Using the spray may have some side effects.

When using the spray, phenomena such as dizziness and nausea may occur. Itching may occur in the nose, causing sneezing and discomfort. The nasal mucosa may dry out.

Depending on the state of health and the presence of chronic diseases, other conditions may appear, such as disturbances in activity (arrhythmia, increased blood pressure) and drowsiness.

It is better to coordinate the use of Lazolvan Rino with your doctor, dosage and treatment period.

Contraindications for use

Allergic dermatitis is a contraindication for taking Lazolvan, especially in childhood. It is not recommended to take the drug for people who have allergic reaction for citrus fruits.

It is contraindicated to use tablets to treat those children who have lactase deficiency, since they contain lactose.

Inhalations with Lazolvan solution are not prescribed to children if they are intolerant to the contents of the drug.

Before purchasing a medicine, its form, method of use and dosage must be agreed with your doctor, who will take everything into account individual characteristics and determine the regimen for taking the drug or suggest its analogues.

Use of Lazolvan during pregnancy and lactation

His negative action on the fetus and the body of a pregnant woman on later not installed. How to take it, and whether it is worth choosing analogs, should definitely be discussed with your doctor.

Lazolvan's analogs

If lazolvan is not suitable for any reason, there is always the opportunity to choose an effective one and maybe more cheap drug. By reading reviews of people who have experience using such medications, you can pay attention to some popular remedies. However, you should not rely only on reviews when choosing a particular medicine. In addition to ambroxol from various pharmaceutical manufacturers, these are:

Ambrobene
Flavamed
Ambrohexal
Frenopect
Ambrosol
Medox et al.

In this article you can find instructions for use medicinal product Lazolvan. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Lazolvan in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications were observed and side effects, perhaps not stated by the manufacturer in the annotation. Analogs of Lazolvan if available structural analogues. Use for the treatment of bronchitis, pneumonia and cough in adults, children, as well as during pregnancy and lactation.

Lazolvan- mucolytic drug.

Studies have shown that ambroxol (the active ingredient in Lazolvan) increases secretion in the respiratory tract. Enhances the production of pulmonary surfactant and stimulates ciliary activity. These effects lead to increased mucus flow and transport (mucociliary clearance). Increasing mucociliary clearance improves sputum discharge and relieves cough.

Pharmacokinetics

Lazolvan is characterized by rapid and almost complete absorption with a linear dose dependence in the therapeutic concentration range. The transition of ambroxol from the blood to tissues when administered orally occurs quickly. The highest concentrations of the active component of the drug are observed in the lungs. Approximately 30% of the dose taken undergoes a first-pass effect through the liver. The remainder of ambroxol is metabolized in the liver, mainly by conjugation.

Indications

Acute and chronic diseases of the respiratory tract, accompanied by the release of viscous sputum:

acute and chronic bronchitis;
pneumonia;
chronic obstructive pulmonary disease;
bronchial asthma with difficulty in sputum discharge;
bronchiectasis.

Release forms

Tablets 30 mg.

Syrup (children's form of the drug).

Solution for oral administration and inhalation.

Lozenges 15 mg.

Instructions for use and dosage

The drug in tablet form is prescribed to adults 30 mg 3 times a day.

If necessary for strengthening therapeutic effect can be prescribed 60 mg 2 times a day. The tablets are taken after meals with liquid.

The drug in the form of a syrup of 15 mg/5 ml is prescribed to adults and children over 12 years of age, 10 ml (2 teaspoons) 3 times a day; children aged 6 to 12 years - 5 ml (1 teaspoon) 2-3 times a day; children aged 2 to 6 years are prescribed 2.5 ml (1/2 teaspoon) 3 times a day; children under 2 years old - 2.5 ml (1/2 teaspoon) 2 times a day.

The drug in the form of a syrup 30 mg/5 ml is prescribed to adults and children over 12 years of age 5 ml (1 teaspoon) 3 times a day; children aged 6 to 12 years - 2.5 ml (1/2 teaspoon) 2-3 times a day.

Taking the drug for more than 4-5 days is possible only under the supervision of a doctor.

Lazolvan in the form of syrup should be taken during meals with liquid.

Lazolvan in the form of an inhalation solution can be used with any modern inhalation device, except for evaporating inhalers. The drug is mixed with saline solution in a 1:1 ratio to achieve optimal air humidification in the respirator.

During inhalation, in order to avoid cough reflex caused by take a deep breath, the patient should breathe calmly. It is recommended to warm the inhaled solution to body temperature. Patients with bronchial asthma are recommended to take inhalations after taking bronchodilators.

Side effect

heartburn;
dyspepsia;
nausea, vomiting;
diarrhea;
skin rash;
hives;
angioedema;
anaphylactic reactions (including anaphylactic shock).

Contraindications

1st trimester of pregnancy;
hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

Lazolvan penetrates the placental barrier.

IN experimental studies in animals, no direct or indirect adverse effects on pregnancy, embryonic, prenatal and postnatal development and childbirth were detected.

Clinical studies during 28 weeks of pregnancy found no evidence of a negative effect of the drug on the fetus.

However, the usual precautions should be taken when using the drug during pregnancy. It is especially not recommended to take Lazolvan in the 1st trimester of pregnancy.

Ambroxol can be excreted in human milk. Therefore, it is not recommended to prescribe Lazolvan to nursing mothers. However, an adverse effect in newborns is unlikely.

special instructions

Should not be used in combination with antitussives that impede the removal of sputum.

Lazolvan syrup (15 mg/5 ml) contains 10.5 g of sorbitol in terms of the maximum recommended daily dose(30 ml). Patients with rare hereditary fructose intolerance should not take this drug. It may also have a mild laxative effect.

Lazolvan syrup (30 mg/5 ml) contains 5 g of sorbitol based on the maximum recommended daily dose (20 ml). Patients with rare hereditary fructose intolerance should not take this drug.

Lazolvan tablets (30 mg) contain 684 mg of lactose based on the maximum recommended daily dose (120 mg). Patients with rare hereditary galactose intolerance, Lapp lactase deficiency or impaired glucose/galactose absorption should not take this drug.

Very rare cases of severe skin lesions have been reported, such as Stevens-Johnson syndrome and Lyell's syndrome; however, the relationship with the drug has not been proven. If the above syndromes develop, it is recommended to stop treatment and immediately seek medical help.

Drug interactions

Simultaneous use with antitussive drugs leads to difficulty in sputum discharge while reducing cough.

Ambroxol increases the penetration of amoxicillin, cefuroxime, erythromycin, and doxycycline into the bronchial secretions.

Lazolvan is compatible with drugs that inhibit labor.

Analogues of the drug Lazolvan

Structural analogues according to active substance:

Ambrobene;
AmbroHEXAL;
Ambroxol;
Ambroxol Vramed;
Ambroxol retard;
Ambroxol-Verte;
Ambroxol-Vial;
Ambroxol-Richter;
Ambroxol-Teva;
Ambroxol-Hemofarm;
Ambrolan;
Ambrosan;
Ambrosol;
Bronchoxol;
Bronchorus;
Deflegmin;
Bronchovern Drops;
Lazolangin;
Medox;
Mucobron;
Neo-Bronchol;
Remebrox;
Suprima-coff;
Fervex for cough;
Flavamed;
Halixol.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.