Is it possible to drink alcohol after Diprospan injection? The combined effect of diprospan and alcohol on the human body.

Diprospan is a glucocorticoid drug. This remedy has pronounced immunosuppressive, anti-allergic and anti-inflammatory effects.

The action of the drug is provided by two biologically active components: betamethasone sodium phosphate and betamethasone sodium phosphate. Due to the combination of these substances, a quick effect and a long-term effect of Diprospan are provided.

Consider the reviews of doctors on the use of the drug Diprospan in the treatment of patients with pathologies musculoskeletal system.

Reviews of doctors about the drug Diprospan

“It is important to convey to the patient that diprospan is still a means of a hormonal nature. This means that there should be no thoughtless and uncontrolled intake of the drug. Only strict medical supervision can be a guarantee effective treatment using diprospan.

As a rule, the course of treatment is limited to three blockades. It is important to maintain an interval of at least 7 days between injections.

Course treatment with this remedy should not be repeated more than 3 times during the year. It is important to remember that glucocorticoids can only be beneficial when used correctly.

If they are not used rationally, it is possible to develop serious complications in various bodies, as well as necrotic changes in their tissues.

Ruslan

“I have been working in traumatology for many years. I am familiar with diprospan firsthand. The most important thing, of course, is to understand both the doctor and the patient that this remedy is hormonal. Such drugs require some caution in use.

Most often I use diprospan in the form of periarticular (periarticular) injections. I know that many people use it for intra-articular injection, but I think that such actions are accompanied by too high risk infection in the joint cavity.

Best Effects from the use of diprospan, in my practice, were achieved in the treatment of enthesopathy (periarthritis), bursitis, periarthrosis, fasciitis, tendonitis and during paravertebral blockades in the lumbar region. I believe that diprospan is a fairly affordable, effective and safe tool in the treatment of pathologies of the musculoskeletal system.”

Alexander

"Diprospan is effective tool to eliminate local pain. At adequate application with observance of doses and frequency of administration, are achieved excellent results with minimal side effects.

The drug is good for muscle and joint pain as well as skin pathologies. However, there are patients who, without consulting a doctor, arbitrarily begin a course of treatment with inadequate doses of the drug.

Such cases, unfortunately, lead to the development of serious multi-organ complications while taking diprospan. Most often, pathological processes begin to manifest themselves in violations of the functionality of the endocrine system, and then in other organs.

Marina

"I often appoint this drug to their patients. I think that diprospan has an optimal price-quality ratio and high efficiency.

Unlike its counterparts in terms of the mechanism of action, diprospan rarely causes the development of side effects in the form of local soft tissue atrophy in the area of ​​drug administration. Excellent tolerance and high efficacy make the drug ideal solution for elimination pain syndrome various etiologies.

Veronica

“Diprospan has clear indications for use. With the correct use of this tool, sufficient efficiency is always achieved. I use the drug both intramuscularly and intraarticularly or periarticularly by the method of administering the drug.

Like any glucocorticoid, diprospan can, with prolonged use, cause the development of various complications. However, with care, this can be avoided.

Svetlana

« I actively use diprospan in practice chiropractor. If it is necessary to carry out a drug blockade, I most often use diprospan. Most effective this method treatment for inflammatory pathologies with a protracted course: lumbalgia, thoracalgia, cervicalgia.

However, the tool is not ideal. In cases where a non-inflammatory component plays a leading role in the pathogenesis of pain, diprospan is ineffective. However, in such situations it is easier differential diagnosis pathology."

margarita

“Diprospan is a good drug. However, its use is most effective when the solution is locally injected into the affected area.

With inadequate introduction of diprospan into the body, the effectiveness of the drug is insufficient. That is why I recommend using diprospan only as one of the components of anti-inflammatory therapy.”

Svetlana

“Diprospan, like any glucocorticoid drug, has a number of positive effects. However, despite this, it should be borne in mind that this medication has a number of contraindications.

So, the doctor should know that diprospan should not be prescribed for diabetes mellitus, Cushing's syndrome, tuberculosis, skin mycoses, mental disorders, during the vaccination period, with stomach ulcers or infectious diseases. The already listed contraindications make it impossible to use the drug in a large percentage of patients.

It is also important to distinguish the side effects of the drug from other conditions of the body. Against the background of taking the drug, side effects such as jumps in blood pressure, Cushing's syndrome, mental disorders, and individual intolerance to the drug may develop.

Alexander

“I would like to note the high effectiveness of the drug in rheumatoid arthritis and other pathologies of the musculoskeletal system, since many people know this remedy as an anti-allergic. As a rule, patients are reluctant to decide on treatment with glucocorticoids, as they associate hormonal drugs with a large number of side effects and lifelong medication.

However, it is worth explaining to patients that there are a number of pathologies that require the appointment of drugs of this pharmacological group. In addition, treatment with glucocorticoids is a course and, with a properly selected scheme, gives a long-term therapeutic effect.

Hope

“The appointment of diprospan requires high competence and caution from the doctor. In spite of good efficiency drug, you should not use diprospan as a primary remedy.

This drug should be prescribed strictly according to the indications and according to an individually selected regimen and dosage. Careless administration of the drug can lead to the development of serious disorders in the patient's body.

Vladimir

“I prescribe diprospan to my patients quite rarely, only in cases of ineffectiveness of other drugs. I believe that such a drug should not be prescribed to everyone, since there are a number of contraindications and side effects».

Irina

« I try in my medical practice as little as possible to resort to the use of glucocorticoids. You should not, after all, abuse the drugs of this series.

When using diprospan, like its analogues, it is important to ensure accurate intake medicinal substance to the location pathological process(for diseases of the musculoskeletal system). As a rule, an injection is made deep into the muscle or into the cavity of the diseased joint.

With the wrong introduction of this agent, the effect may be noticeably lower or absent altogether. Glucocorticoids have a pronounced anti-inflammatory effect, but in some cases this is not enough. With pathologies of the musculoskeletal system, an integrated approach to treatment is important.”

Jeanne

“Diprospan is one of the injectable drugs of the glucocoticoid series. The main advantage of this tool is that it contains a fast-acting and prolonged form of betamethasone.

Thanks to these components, the effect of the use of this drug comes quickly and lasts for some time (the prolonged form of betamethasone is excreted from the body no earlier than after 10 days). Thus, diprospan can be effectively used both as a emergency care patient, and for planned treatment.

Anastasia

“I believe that diprospan acts in the same way as other drugs of this pharmacological group. You can just as well use any other glucocorticoid drug at a more affordable price.

Michael

“In my medical practice, I encountered a patient who arbitrarily used diprospan for joint pain. He began treatment on his own, having learned that it helped a neighbor. As a result, Cushing's syndrome developed, muscle atrophy (at the injection site) and damage to the liver, kidneys, and cardiovascular system.

I would like to draw the reader's attention to the fact that diprospan, like any remedy in this group, should be prescribed exclusively by a doctor. In addition to excluding contraindications to the use of the drug, you should choose the dose of the drug and the scheme of its use.

Stanislav

“I prescribed diprospan to my patients only a few times. In most of these cases, patients noted the development of side effects, such as: nausea, weakness, dizziness, increased blood pressure, weight gain. Perhaps this is just a coincidence, but for myself I decided to use other drugs of this series.

In medicine, such a combination as Diprospan and any alcohol is considered dangerous. Reviews of doctors often confirm this. But what is the reason for this incompatibility?

It should be understood that Diprospan is a hormonal agent, it belongs to the group of glucocorticosteroids. It has a fairly wide spectrum of action. For example, it has: anti-allergic, anti-inflammatory, anti-shock, immunosuppressive effect. It is prescribed after serious injuries, to relieve pain, after operations. But what do the reviews say about it?

Drug Overview

The active substance is betamethasone. The drug is a colorless (or slightly yellow) liquid, which sometimes has a precipitate. Produced in ampoules, which are used for injections. In the package you can find one or five pieces of 1 ml of the product. One ml contains betamethasone dipropionate and betamethasone sodium phosphate.

Indications for use

You can use this tool if all the rules of asepsis are strictly observed. The injection syringe should be shaken well before use.

Diseases when medication is indispensable:

Rheumatic reactions:

• rheumatism, which is represented by myositis, tendosynovitis, fibrositis or epicondylitis,
• different types of arthritis.

Allergic reactions:

• rhinitis,
• allergic reactions,
• bronchial asthma,
• different types of dermatitis,
• anaphylactic shock.

Pathological reactions from the gastrointestinal tract:

• manifestations of ulcerative colitis

From other systems:

• post-traumatic osteomyelitis,
• osteochondrosis,
• lumbago,
• cerebral edema,
• collagenosis,
• shock states,
• hepatitis,
• keloid scars,
• malignant neoplasms,
• acute gouty arthritis.

Use during pregnancy and lactation

It is necessary to take into account the fact that Diprospan has the ability to actively penetrate the hematoplacental barrier, this boils down to the fact that its use during pregnancy is undesirable. Young mothers should also be aware of the excretion of the substance with milk, and during the period of use of the medication it is worth giving up breastfeeding, this will be confirmed by the reviews.

It is important to know that it is the doctor who should prescribe the exact appointment for you, you should not self-medicate!

Application methods

• Intramuscular
• Intradermal
• Intra-articular (Introduced into the joint cavity) or periarticular (into the tissues surrounding the joint)

You should know that intravenous administration is a strict contraindication.

The dose, as well as the method of administration, depends on the clinic and the course of the disease.

Adverse reactions and contraindications

Like any other medication, Diprospan has side effects that must be considered when taking this remedy:

• CNS problems: lack of sleep and apathy, anxiety and depression, excessive excitement and euphoria;
• Problems with the gastrointestinal tract: indigestion, erosion or ulcers, flatulence;
• Allergic reactions: anaphylactic shock, angioedema;
• When administered intradermally - problems with the skin and subcutaneous fat;
• Also, the development of osteoporosis, weight gain and growth problems in children is not excluded;
• increased sweating;
• Steroid acne;
• pyoderma;
• Candidiasis;
• Petechiae, ecchymosis;
• Striae.

Absolute contraindication is a very high sensitivity to betamethasone or other components of the injection drug.

Contraindications include:

1. Increased fragility of cartilage and bones. The medication will make all cartilage brittle, so every careless movement can end very badly. And given the fact that when drunk, a person does not control his activities, and falling for him is easier than ever. Therefore, no fractures in this case will not do.
2. Significant weakening of the immune system. The drug will help weaken the immune system, which is caused by the use of alcohol. If a course of treatment is being taken, the purpose of which is to remove existing inflammation, then the effect will be fundamentally the opposite. Existing inflammation will be transferred to the joints and blood vessels.
3. Muscle weakness. Alcohol gives a state of relaxation, and the substance of the drug itself causes the same effect on muscle tissue. Therefore, it is possible that for some time a person can completely stop feeling his body.
4. Growth blood pressure. Ethyl alcohol, entering the blood, will directly affect this indicator, and if the pressure has already been increased, then the combination of injection and ethyl is strictly prohibited. If there are pressure drops, then the course of treatment must be carried out very carefully under the supervision of a doctor.
5. Panic. One of the negative phenomena of combining two drugs is the appearance of a panic state and depression in a person. This can manifest itself in committing rash acts, constant throwing in the room. It is very important to control this condition, as reviews say, it passes within 20 minutes. After it, the patient notices a rather high drowsiness.
6. Severe hangover. Medicines at times can enhance all the negative phenomena that appear to a person after taking a large dose of alcohol. All of them will be multiplied several times, so there will be a similar situation with an overdose of the drug. It is advisable to prevent such a condition, if it appears, you need to urgently consult a doctor.

Diprospan and alcohol - compatibility is dangerous. It is important to remember that joint reception drugs and alcohol can immediately increase the burden on the entire body.

In addition, since the drug has medicinal property on one group of organs, another, because of alcohol, it can harm. It is quite difficult in some people to predict the possible consequences of the use of diprospan after alcohol. The drug is contraindicated in those who have quite strong deviations and mental disorders during alcohol intoxication. Therefore, for those who have a mental disorder, it is advisable to completely avoid this medication so as not to get an aggravation of the problem.

Speaking about the state of alcoholic intoxication, it is worth knowing that symptoms such as nausea, vomiting and dizziness are prerequisites for refusing to inject this drug. An injection can not only complicate the situation, but also adversely affect the gastrointestinal tract, many reviews speak of digestive problems.

If there are situations that it is impossible to refuse injections, then before it is carried out, it is necessary to thoroughly rinse the stomach, and then put a dropper. At this time, the patient should be observed by a specialist. Only after that you can resort to the use of the drug.

Regardless of the strength of alcohol, any kind will not go well with diprospan. As a result, it greatly increases pernicious influence drug on the human body. If we talk about red wine, then it must also be excluded from the diet. It will be able to raise blood sugar very quickly, like any variants of sugary liquor. Such a phenomenon may lead to man will fall in a coma.

It is important to remember that there is no such medication that can withstand the harmful effects of alcohol and diprospan. Side effects will occur a couple of hours after the combination, and if this still happened, then it is desirable that the patient be observed by a highly qualified specialist. That's the only way to avoid serious consequences for the body.

All materials on our site are intended for those who care about their health. But we do not recommend self-medication - each person is unique, and one or another means and methods cannot be used without consulting a doctor. Be healthy!

Diprospan is an injectable drug used in most cases in the treatment of pathologies of the musculoskeletal system.
But this medicine also has another pharmacological action - anti-allergic, so Diprospan can be prescribed to eliminate certain types of allergies.

The medication must be used according to the scheme, taking into account all the nuances of its introduction. Otherwise, treatment with Diprospan can cause quite serious complications.

Trade name and active substance

Tradename medication - Diprospan (Diprospan). The main active ingredient is betamethasone (Betamethasone).

Description

The drug is produced in Belgium. The registered office of Schering-Plow Labo N.V., Indushtrypark 30. international name commonly used is betamethasone.

Diprospan is available only in the form of a suspension - a viscous solution, colorless or slightly yellowish color. After shaking, the liquid becomes homogeneous and acquires White color.

The suspension consists of two active ingredients - betamethasone dipropionite and betamethasone sodium phosphate.

In addition to the main components in the preparation are auxiliary:

1. Anhydrous dibasic sodium phosphate;
2. Trilon B;
3. Water for injections;
4. Polysorbate 80;
5. benzyl alcohol;
6. Carboxymethylcellulose sodium salt;
7. Polyethylene glycol 4000;
8. Nipazol;
9. Nipagin.

The suspension is packaged in glass ampoules with a dosage of 1 ml. There may be one or five ampoules in a plastic package.

Pharmacological group

Diprospan belongs to the group of glucocorticosteroid drugs, which are hormonal means.

pharmachologic effect

Betamethasone, which is the active ingredient of Diprospan, belongs to a highly active class of glucocorticosteroids. Due to betamethasone, the drug has a pronounced anti-inflammatory, immunosuppressive and anti-allergic effect.

After entering the blood, the synthetic hormone binds to albumin proteins, after which it is quickly transferred to all cells of the body.

The effectiveness of Diprospan in the treatment of allergic reactions is explained by the ability of betemethasone to suppress the production of aggressive enzymes that cause inflammatory response mucous membranes and skin.

Chemical structure Diprospana is similar to the structure of adrenal hormones, so the drug begins to actively participate in all types of metabolism in the body - carbohydrate, protein, fat, water-salt.

At the same time, everything natural reactions accelerate, which is not always beneficial for the body - long-term use of glucocorticosteroids causes unwanted side changes.

The high therapeutic effect of the use of Diprospan is explained by the fact that its two active components act in different ways:

1. Betamethasone in the form of sodium phosphate after injection quickly dissolves and spreads throughout the body. Thanks to this, the therapeutic effect occurs literally within 20-60 minutes. This form of the hormone lingers in the body for no more than a day.
2. Betamethasone dipropionate is a microcrystalline fraction, which, after entering the body, is converted into a kind of depot. From this depot, betamethasone comes out gradually, at a small dose for 20-25 days.

The dual mechanism of Diprospan's work allows you to achieve two goals with.

Under the influence of the drug, the acute symptoms of an allergic reaction are almost instantly stopped, and then a remission occurs, lasting for at least three weeks.

The components of the drug are completely metabolized in the liver and excreted by the kidneys.

Indications for use

Diprospan must be prescribed by a doctor. In some diseases, glucocorticosteroids are only additional medicines.

The drug is prescribed to patients with:

• Pathologies musculoskeletal system and soft tissue diseases, including bursitis, rheumatoid arthritis, osteoarthritis, sciatica, fasciitis, spondyloarthritis, torticollis, lumbago, foot disease.
• Allergic diseases. Most often, Diprospan is prescribed to those who have a history of bronchial asthma, allergic bronchitis, hay fever, seasonal or year-round. The drug is considered a first aid for drug allergy, serum sickness, with an acutely developing reaction to.
• Dermatological diseases - coin-shaped eczema, neurodermatitis, atonic and contact dermatitis, urticaria, photodermatitis, lichen planus. Often, Diprospan is part of the complex therapy of alopecia areata, cystic acne, herpetic dermatitis and a number of other pathologies affecting the skin.
• Hemoblastoses. Diprospan is included in the scheme of palliative therapy for leukemia and lymphomas.
• Secondary and primary insufficiency of the adrenal cortex.

Diprospan is also used in the treatment of a number of diseases requiring systemic exposure to corticosteroids (glucocorticosteroids). it ulcerative colitis, adrenogenital syndrome, malabsorption, nephrotic syndrome, regional ileitis.

Instructions for use

Diprospan is an injectable drug. It is allowed to administer it intramuscularly, into the joint or near it, less often intrabursal, intradermal and interstitial injections are prescribed.

The drug should be administered only by specialists who have the appropriate certificate.

Diprospan should be injected into the joint and tissues by a doctor. It is imperative to follow all the rules of asepsis, the dosing regimen is set for each patient individually.

When conducting intramuscular injection a single dose of the drug usually does not exceed two milliliters. It is necessary to re-introduce the drug after assessing all changes.

After Diprospan helps to cope with the elimination of severe symptoms of diseases, a maintenance dose is selected. To do this, the dose of the suspension is reduced over several weeks, observing the patient's well-being.

Contraindications

Hypersensitivity to betamethasone or to additional components of the drug is considered an absolute contraindication to the appointment of Diprospan.

Subcutaneous and intravenous injections. If the drug is planned to be injected into the joint, then infectious arthritis and an unstable joint are contraindications.

Diprospan cannot be injected into infected tissues, into the intervertebral space; treatment with them is prohibited for systemic mycoses.

Carefully

If long-term treatment with glucocorticosteroids is planned, then it is necessary to find out if the patient has a history of diseases that can become relative contraindications:

• severe hypertension;
• Purulent and viral infections;
• Diabetes;
• Cushing's syndrome;
• Stomach ulcer;
• Glaucoma;
• Tuberculosis;
• mental illness;
• thromboembolic syndrome.

Intramuscularly, the drug is not administered with thrombocytopenic purpura.

Temporary contraindications are the resulting foci of psoriasis or necrosis at the intended injection site, treatment with anticoagulant drugs.

Overdose

In most cases, the introduction of high doses of Diprospan suspension for several days does not lead to a deterioration in the patient's well-being and complications.

An overdose may develop if GCS is used to treat patients with diabetes mellitus, with an ulcerative lesion of the gastrointestinal tract in the acute stage.

Drugs such as Digitalis, potassium-removing diuretics, and indirect anticoagulants can also enhance the glucocorticosteroid effect.

Overdose symptoms:

1. Nausea and vomiting;
2. sleep disorders;
3. Excitation;
4. Euphoria;
5. Depression.

If an overdose is detected, Diprospan is canceled gradually, therapy is prescribed to maintain vital functions.

It is necessary to correct the water and electrolyte balance, if necessary, antacids, phenothiazines are prescribed.

How often to prick Diprospan

The frequency of administration of Diprospan, and its dosage depends on the type of disease:

• With rheumatoid arthritis, the drug is placed in the joint once every two to three months. The interval between setting in different joints should be at least one week.
• In the treatment of alopecia, Diprospan is placed into the muscle once a week, the course of treatment is up to 5 injections.
• With eczema, the drug is prescribed only in case of its severe course. The number of injections is selected by the doctor, taking into account changes in the skin.

Diprospan for allergies is used in different ways:

• For cupping acute manifestations asthma, bronchitis, conditions after insect bites or when a single administration of the drug is prescribed at a dose of 1-2 ml. Further treatment is carried out with other medicines.
• In the treatment of pollinosis, rhinitis, a treatment regimen is chosen in which Diprospan is administered every day, 1-2 ml, for 5 to 10 days.

It is strictly forbidden to increase the frequency of administration of a suspension of glucocorticosteroid without the permission of a doctor - synthetic hormones have quite pronounced side reactions and failure to follow the scheme of their administration leads to complications.

How harmful is the drug

With proper dose selection and a short course of treatment adverse reactions almost never develop.

Most often, unwanted changes in the body occur with prolonged use and they are associated with the fact that betamethasone inhibits the function of the pituitary gland.

Possible side effects:

At the injection site of Diprospan, the occurrence of foci of hyper or hypopigmentation, atrophy of subcutaneous fat and skin, abscesses are not excluded.

With intra-articular injections of the drug, the likelihood of developing sepsis increases, damage to the tendons, nerves, cartilage, and hemorrhages into the joint cavity are not excluded.

Frequent injections can cause microcrystalline arthritis.

Interaction with other drugs

When prescribing Diprospan for a long period, it is necessary to consider what other drugs the patient is taking:

• Azathioprine, when used simultaneously with corticosteroids, increases the risk of developing cataracts and myopathy.
• ibuprofen, anabolic steroid, delagil increase the likelihood of developing all side effects from Diprospan.
• The combination of Isoniazid and Diprospan leads to a decrease in concentration, the appearance of mental disorders.
• Medicines with an antiepileptic effect reduce the concentration of betamethasone.
• Simultaneous treatment Diprospan and non-steroidal anti-inflammatory drugs increase the risk of ulcerative lesions of the digestive tract.
• Estrogens (which include contraceptives) enhance the therapeutic effect of betamethasone.
• Antidepressants, when used simultaneously with a synthetic hormone, can cause increased intraocular pressure.
• Simultaneous treatment with Diprospan and antibiotics reduces the risk of developing allergies from taking antibiotic therapy.

Special instructions for use

Diprospan suspension is not intended for intravenous or subcutaneous injection. Injection into a vein and under the skin leads to a host of complications, some of which may require immediate resuscitation.

When prescribing and staging Diprospan, the following recommendations should be observed:

• Parenteral administration of a corticosteroid can cause anaphylactoid reactions. Therefore, the patient should find out the entire allergic history and observe all precautions at the time of the injection.
• With a tendency to psychosis and emotional instability, it is possible to develop mental disorders.
• Patients treated with corticosteroids are not vaccinated against smallpox. Also, against the background of hormone treatment, immunization with any drugs is temporarily prohibited due to the fact that this can cause low feedback immunity and neurological disorders.
• In the treatment of corticosteroids, it should be borne in mind that these drugs smooth out the signs of infections and reduce the body's resistance.
• When the drug is injected into the joint, infectious arthritis should be excluded, since against the background of this disease, the corticosteroid can cause destruction of the joint tissue.
• When the drug is injected into the joint, the patient needs to reduce the load on the affected area.
• An ophthalmological examination is necessary for those patients who are treated with Diprospan for more than 6 months.
• If, during the treatment of GCS, blood pressure rises, signs of fluid retention are noted, then the patient is recommended a certain diet therapy with a decrease in the amount of salt.
• Rapid withdrawal of a corticosteroid after long-term treatment may cause secondary adrenal insufficiency. Careful adherence to the cancellation scheme helps to avoid this.
• With long-term treatment, it is advisable to replace parenteral administration with oral forms of glucocorticosteroids.

Diprospan and alcohol

Glucocorticosteroids are those drugs that increase the body's tolerance to ethyl alcohol. This reduces the toxic effect of alcohol, but its concentration remains the same.

This property of the drug is used in the treatment of patients with acute poisoning. ethyl alcohol.

Children and during pregnancy

Is it possible to use the drug for administration to children, during pregnancy and lactation.

Studies of the safety of Diprospan on the body of a pregnant woman have not been conducted, in connection with this, the decision to prescribe GCS during the period of bearing a child should be made only taking into account the possible negative impact to the fruit.

The corticosteroid crosses the placenta, so newborns of those mothers who received corticosteroids should be monitored for a long time. It helps to set early violations.

During lactation, GCS should be prescribed only when breastfeeding. If pregnancy occurred when a woman was taking Diprospan, then it should be canceled gradually.

Long term treatment Diprospan in children can cause a delay in sexual development and growth of the child. As such, they must be constantly monitored.

During the period of treatment with corticosteroids, it is necessary to ensure that children do not come into contact with patients with chickenpox and measles.

Also at this time, vaccination is prohibited - glucocorticosteroids do not allow antibodies to form, so the vaccine is ineffective.

Drug analogues

The absolute analogue of Diprospan is the drug Flosteron.

Conditions of storage and dispensing in pharmacies

The drug should be sold in pharmacies only on presentation of a prescription from a doctor. It is necessary to store ampoules where the temperature is not higher than 25 degrees.

The cost of one ampoule of Diprospan starts from 177 to 240 rubles.

In this article, you can read the instructions for using the drug Diprospan. Reviews of site visitors - consumers are presented this medicine, as well as the opinions of doctors of specialists on the use of Diprospan in their practice. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Diprospan analogues if available structural analogues. Use for treatment inflammatory diseases in adults, children, as well as during pregnancy and lactation.

Diprospan- glucocorticosteroid (GCS) drug, has high glucocorticoid and insignificant mineralocorticoid activity. The drug has anti-inflammatory, anti-allergic and immunosuppressive effects, and also has a pronounced and diverse effect on various types of metabolism.

Pharmacokinetics

Betamethasone sodium phosphate (the active substance of the drug Diprospan) is highly soluble in water and, after intramuscular injection, is rapidly hydrolyzed and absorbed almost immediately from the injection site, which ensures a rapid onset of therapeutic action. Almost completely eliminated within one day after administration. It is excreted mainly by the kidneys.

Indications

Treatment in adult conditions and diseases in which corticosteroid therapy achieves the desired clinical effect (it should be borne in mind that in some diseases of corticosteroid therapy, therapy is additional and does not replace standard therapy):

• diseases of the musculoskeletal system and soft tissues, incl. rheumatoid arthritis, osteoarthritis, bursitis, ankylosing spondylitis, epicondylitis, coccygodynia, torticollis, ganglion cyst, fasciitis;
• allergic diseases, incl. bronchial asthma, hay fever (hay fever), allergic bronchitis, seasonal or year-round rhinitis, drug allergy, serum sickness, reactions to insect bites;
• dermatological diseases, including atopic dermatitis, nummular eczema, neurodermatitis, contact dermatitis, severe photodermatitis, urticaria, red lichen planus, alopecia areata, discoid lupus erythematosus, psoriasis, keloid scars, pemphigus vulgaris, cystic acne;
• systemic connective tissue diseases, including systemic lupus erythematosus, scleroderma, dermatomyositis, periarteritis nodosa;
• hemoblastosis (palliative therapy for leukemia and lymphomas in adults; acute leukemia in children);
• primary or secondary insufficiency of the adrenal cortex (with mandatory simultaneous application mineralocorticoids);
• other diseases and pathological conditions requiring systemic corticosteroid therapy (adrenogenital syndrome, regional ileitis, pathological changes blood if it is necessary to use corticosteroids).

Release form

Suspension for injection (including for injection into the joint).

Solution for injection (injections in ampoules).

Instructions for use and method of use

Intramuscular, intraarticular, periarticular, intrabursal, intradermal, interstitial and intralesional injections. The small size of betamethasone dipropionate crystals allows the use of small diameter needles (up to 26 gauge) for intradermal administration and injection directly into the lesion.

The drug is administered using a disposable syringe using needles (0.5x25 mm and 0.8x50 mm in size) included in the kit.

DO NOT ENTER INTRAVENOUSLY! DO NOT ENTER SUBCUTANEOUSLY!

Strict observance of asepsis rules is mandatory when using Diprospan. The syringe should be shaken before use.

With systemic therapy, the initial dose of Diprospan in most cases is 1-2 ml. The introduction is repeated as necessary, depending on the condition of the patient.

I / m administration of GCS should be carried out deep into the muscle, while choosing large muscles and avoiding contact with other tissues (to prevent tissue atrophy).

The drug is administered intramuscularly:

• in severe conditions requiring acceptance emergency measures; the initial dose is 2 ml;
• with various dermatological diseases; as a rule, it is enough to introduce 1 ml of Diprospan suspension;
• in diseases respiratory system. The onset of action of the drug occurs within a few hours after the / m injection of the suspension. At bronchial asthma, hay fever, allergic bronchitis and allergic rhinitis, a significant improvement in the condition is achieved after the introduction of 1-2 ml of Diprospan;
• in acute and chronic bursitis, the initial dose for i / m administration is 1-2 ml of suspension. If necessary, carry out several repeated injections.

If a satisfactory clinical response does not occur after a certain period of time, Diprospan should be discontinued and another therapy prescribed.

With local administration, the simultaneous use of a local anesthetic drug is necessary only in rare cases. If desired, 1% or 2% solutions of procaine hydrochloride or lidocaine, free of methylparaben, propylparaben, phenol and other similar substances, are used. In this case, mixing is carried out in a syringe, first drawing the required dose of Diprospan suspension into the syringe from the vial. Then, the required amount of local anesthetic is taken from the ampoule into the same syringe and shaken for a short period of time.

In acute bursitis (subdeltoid, subscapular, elbow and prepatellar), the introduction of 1-2 ml of the suspension into the synovial bag relieves pain and restores joint mobility within a few hours. After relief of exacerbation in chronic bursitis, smaller doses of the drug are used.

In acute tendosynovitis, tendonitis and peritendinitis, one injection of Diprospan improves the patient's condition; in chronic cases, the injection is repeated depending on the patient's response. Avoid injecting the drug directly into the tendon.

Intra-articular administration of Diprospan at a dose of 0.5-2 ml relieves pain, limitation of joint mobility in rheumatoid arthritis and osteoarthritis within 2-4 hours after administration. The duration of the therapeutic effect varies considerably and can be 4 or more weeks. The recommended doses of the drug when administered in large joints are from 1 to 2 ml; in the middle - 0.5-1 ml; in small ones - 0.25-0.5 ml.

Featured single doses the drug (with an interval between injections of 1 week) with bursitis: with callus 0.25-0.5 ml (usually 2 injections are effective), with a spur - 0.5 ml, with limited mobility thumb feet - 0.5 ml, with synovial cyst - 0.25-0.5 ml, with tendosynovitis - 0.5 ml, with acute gouty arthritis- 0.5-1.0 ml. For most injections, a tuberculin syringe with a 25-gauge needle is suitable. After achieving a therapeutic effect, the maintenance dose is selected by gradually reducing the dose of betamethasone administered at appropriate intervals. The reduction is continued until the minimum effective dose is reached.

Side effect

• fluid retention in tissues;
• chronic heart failure (in predisposed patients);
• increased blood pressure;
• muscle weakness;
• the loss muscle mass;
• osteoporosis;
• compression fracture of the spine;
• aseptic necrosis of the head of the femur or humerus;
• pathological fractures of tubular bones;
• tendon ruptures;
• erosive and ulcerative lesions gastrointestinal tract with possible subsequent perforation and bleeding;
• flatulence;
• impaired wound healing;
• atrophy and thinning of the skin;
• petechiae, ecchymosis;
• increased sweating;
• steroid acne;
• striae;
• tendency to develop pyoderma and candidiasis;
• convulsions;
• promotion intracranial pressure with disc edema optic nerve(often at the end of therapy);
• dizziness;
• headache;
• euphoria;
• mood changes;
• depression (with severe psychotic reactions);
• increased irritability;
• insomnia;
• violation of the menstrual cycle;
• secondary adrenal insufficiency (especially during the period of stress due to illness, injury, surgery);
• Itsenko-Cushing's syndrome;
• decreased carbohydrate tolerance;
• violation of intrauterine development;
• growth retardation and sexual development in children;
• increased intraocular pressure;
• glaucoma;
• weight gain;
• anaphylactic reactions;
• angioedema;
• lowering blood pressure;
• a rush of blood to the face after an injection (or intra-articular injection).

Contraindications

• hypersensitivity to betamethasone or other components of the drug, or other corticosteroids;
• systemic mycoses;
• intravenous or subcutaneous administration;
• with intra-articular injection: unstable joint, infectious arthritis;
• introduction into infected cavities and into the intervertebral space;
• children's age up to 3 years (the presence of benzyl alcohol in the composition);
• coagulation disorders (including treatment with anticoagulants).

Use during pregnancy and lactation

Due to the lack of controlled safety studies of the use of Diprospan during pregnancy, the use of the drug in pregnant women or in women of childbearing age requires a preliminary assessment of the intended benefits and potential risks to the mother and fetus. Newborns whose mothers received therapeutic doses of corticosteroids during pregnancy should be under medical supervision (for early detection of signs of adrenal insufficiency).

If it is necessary to prescribe Diprospan during lactation, the issue of stopping breastfeeding should be decided, taking into account the importance of therapy for the mother (due to possible side effects in children).

special instructions

The dosage regimen and method of administration are set individually, depending on the indications, the severity of the disease and the patient's response.

The dose should be as low as possible and the period of application as short as possible. The initial dose is selected until the desired therapeutic effect is achieved. If after a sufficient period of time a therapeutic effect is not observed, the drug is discontinued by gradually reducing the dose of Diprospan and another appropriate method of treatment is selected.

After achieving a therapeutic effect, the maintenance dose is selected by gradually reducing the dose of betamethasone administered at appropriate intervals. The reduction is continued until the minimum effective dose is reached.

If a stressful situation (not associated with a disease) occurs or is threatened, it may be necessary to increase the dose of Diprospan. Cancellation of the drug after prolonged therapy is carried out by gradually reducing the dose.

The patient's condition is monitored for at least a year after the end of long-term therapy or use in high doses.

The introduction of the drug into soft tissues, into the lesion and into the joint can, with severe local action simultaneously lead to systemic action. Given the likelihood of developing anaphylactoid reactions with parenteral administration GCS, should be accepted necessary measures precautions before administering the drug, especially if the patient has a history of allergic reactions to drugs.

Diprospan contains two active substances - derivatives of betamethasone, one of which - betamethasone sodium phosphate - quickly penetrates into the systemic circulation. When prescribing Diprospan, one should take into account the possible systemic effect of the rapidly soluble fraction of the drug.

Against the background of the use of Diprospan, mental disorders are possible (especially in patients with emotional instability or a tendency to psychosis).

When prescribing Diprospan to patients with diabetes mellitus, correction of hypoglycemic therapy may be required.

Patients receiving glucocorticosteroids should not be vaccinated against smallpox. Other immunizations should not be carried out in patients receiving corticosteroids (especially in high doses), due to the possibility of developing neurological complications and a low immune response (lack of antibody formation). However, immunization is possible with replacement therapy(for example, with primary insufficiency of the adrenal cortex).

Patients receiving Diprospan at doses that suppress immunity should be warned about the need to avoid contact with patients. chickenpox and measles (especially important when prescribing the drug to children).

When using Diprospan, it should be borne in mind that corticosteroids can mask signs of an infectious disease, as well as reduce the body's resistance to infections. The appointment of Diprospan in active tuberculosis is possible only in cases of fulminant or disseminated tuberculosis in combination with adequate anti-tuberculosis therapy. When prescribing Diprospan to patients with latent tuberculosis or positive reaction on tuberculin, the issue of prophylactic anti-tuberculosis therapy should be resolved. At preventive use rifampin should take into account the acceleration of hepatic clearance of betamethasone (dose adjustment may be required).

In the presence of fluid in the joint cavity, a septic process should be excluded. A noticeable increase in soreness, swelling, an increase in the temperature of the surrounding tissues and a further restriction of joint mobility indicate infectious arthritis. When confirming the diagnosis, it is necessary to prescribe antibiotic therapy.

Repeated injections into a joint for osteoarthritis may increase the risk of joint destruction. The introduction of GCS into the tendon tissue gradually leads to tendon rupture. After successful intra-articular therapy, the patient should avoid overloading the joint.

Long-term use GCS can lead to posterior subcapsular cataracts (especially in children), glaucoma with possible damage to the optic nerve, and may contribute to the development of a secondary eye infection (fungal or viral). It is necessary to periodically conduct an ophthalmological examination, especially in patients receiving Diprospan for more than 6 months.

With an increase in blood pressure, fluid retention and sodium chloride in the tissues and an increase in the excretion of potassium from the body (less likely than with other corticosteroids), patients are recommended a diet with a restriction table salt and additionally prescribe potassium-containing drugs. All corticosteroids increase the excretion of calcium.

With the simultaneous use of Diprospan and cardiac glycosides or drugs that affect the electrolyte composition of the plasma, control of the water and electrolyte balance is required.

With caution, acetylsalicylic acid is prescribed in combination with Diprospan for hypoprothrombinemia.

The development of secondary adrenal insufficiency due to too rapid withdrawal of GCS is possible within a few months after the end of therapy. If a stressful situation occurs or threatens to occur during this period, Diprospan therapy should be resumed and a mineralocorticoid drug should be prescribed at the same time (due to possible violation secretion of mineralocorticoids). The gradual cancellation of GCS can reduce the risk of developing secondary adrenal insufficiency.

Against the background of the use of GCS, a change in the mobility and number of spermatozoa is possible. With long-term therapy with corticosteroids, it is advisable to consider the possibility of switching from parenteral to oral corticosteroids, taking into account the assessment of the benefit / risk ratio.

Application in pediatrics

Children who are treated with Diprospan (especially long-term) should be under close medical supervision for possible growth retardation and the development of secondary adrenal insufficiency.

drug interaction

With the simultaneous appointment of phenobarbital, rifampin, phenytoin or ephedrine, it is possible to accelerate the metabolism of the drug while reducing its therapeutic activity.

With the simultaneous use of corticosteroids and estrogens, dose adjustment of the drugs may be required (due to the risk of their overdose).

At joint application Diprospan and potassium-removing diuretics increase the likelihood of developing hypokalemia.

The simultaneous use of corticosteroids and cardiac glycosides increases the risk of arrhythmia or digitalis intoxication (due to hypokalemia). Diprospan may increase the excretion of potassium caused by amphotericin B. With the combined use of Diprospan and indirect anticoagulants changes in blood coagulability are possible, requiring dose adjustment.

With the combined use of corticosteroids with non-steroidal anti-inflammatory drugs or with ethanol and ethanol-containing drugs, an increase in the frequency of occurrence or intensity is possible. erosive and ulcerative lesions GIT.

With the combined use of corticosteroids, they can reduce the concentration of salicylates in the blood plasma.

The simultaneous administration of corticosteroids and somatotropin can lead to a slowdown in the absorption of the latter (doses of betamethasone in excess of 0.3-0.45 mg / m2 of body surface per day should be avoided).

Diprospan's analogues

Structural analogues according to active substance:

• Akriderm;
• Beloderm;
• Betazon;
• Betamethasone;
• Betamethasone valerate;
• Betamethasone dipropionate;
• Betliben;
• Betnovate;
• Kuterid;
• Flosteron;
• Celestoderm-B;
• Celeston.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

The composition of the drug injections includes betamethasone dipropionate , equivalent to pure betamethasone in the amount of 2 mg and 5 mg.

Additional components are: sodium edetate, methyl parahydroxybenzoate, injection water, sodium phosphate, benzyl alcohol, nipagin, sodium chloride, polysorbate 80, nipazole, sodium carboxymethylcellulose, polyethylene glycol 4000, propyl parahydroxybenzoate and trilon B.

Release form

Suspension for injection in ampoules or disposable syringes.

pharmachologic effect

Glucocorticosteroid . The active component is . The mechanism of action is based on the inhibition of the release processes interleukins 1 and 2, gamma from macrophages and lymphocytes. The drug has anti-allergic, anti-shock, anti-inflammatory, immunosuppressive, anti-toxic and desensitizing effects. Diprospan does not affect the rate of circulating beta-endorphin, but inhibits the release of beta-lipotropin and ACTH from.

Hormonal or not? The drug is hormonal.

Pharmacodynamics and pharmacokinetics

The drug is able to inhibit the secretion of FSH and TSH. The drug Diprospan stimulates the production, increases the number erythrocytes , reduces the number of eosinophils and lymphocytes, increases the excitability of the central nervous system. When the active component interacts with specific, cytoplasmic receptors, a complex is formed that is able to penetrate into the cell, into its nucleus and stimulate the process of mRNA synthesis (it is this that induces the formation of lipocortin and other proteins that mediate cellular effects). Licortin inhibits the release process arachidonic acid , inhibits phospholipase A2, inhibits the process of synthesizing leukotrienes, and endoperoxides, which are actively involved in inflammatory processes, in the formation of an allergic response. Under the action of diprospan, the amount of protein in the blood plasma decreases due to globulins , but at the same time, the albumin / globulin ratio increases, the production of albumins in the tissues of the kidneys and liver increases, and protein catabolism in muscle tissues increases.

The effect of Diprospan on lipid metabolism: redistribution of fat ( body fat localized mainly in the abdomen, face, shoulder girdle), increased synthesis triglycerides and higher fatty acids, the formation of hypercholesterolemia. The effect of the drug on carbohydrate metabolism: activation of phosphoenolpyruvate carboxylase, increased synthesis of aminotransferases (leads to activation of gluconeogenesis), increased absorption of carbohydrates from the digestive tract, increased activity of glucose-6-phosphatase (increases the flow of glucose into the blood from the liver).

The effect of the drug on water-electrolyte exchange : stimulation of the excretion of potassium ions, retention of water and sodium ions in the body, "washing out" of calcium ions from the skeletal system, reduced absorption of calcium ions from the digestive tract, increased excretion of calcium ions by the renal system. The anti-inflammatory effect is achieved by inhibiting the release of inflammatory mediators by eosinophils; by reducing the number mast cells (they produce hyaluronic acid), inducing the formation of lipocortin, by stabilizing organelle membranes (lysosomal organelles are of particular importance), stabilizing cell membranes, by reducing capillary permeability.

The anti-allergic effect is achieved by suppressing the secretion and synthesis of allergy mediators, inhibiting the process of antibody formation, by changing the body's immune response, reducing the sensitivity to allergic mediators of effect cells, by inhibiting the release of biologically active substances and histamine from mast cells, T-lymphocytes, B -lymphocytes.

In COPD, the drug Diprospan prevents and inhibits the development of swelling of the mucous membranes, slows down the course of inflammatory processes, slows down the deposition of circulating immune complexes in mucous membranes bronchial tree, reduces the rate of eosinophilic infiltration of the submucosal layer in the epithelium of the bronchial tree. The drug inhibits the process of desquamation and erosion of the mucous membranes. By reducing production and inhibiting the production of mucus, its viscosity decreases. Antitoxic and antishock effects are achieved by increasing blood pressure by vasoconstriction, increasing the level of catecholamines circulating in the blood and restoring the sensitivity of adrenoreceptors to them. The effect is achieved by activating liver enzymes that are involved in xenobiotics and endobiotics, by reducing the permeability of vascular walls, and also due to membrane-protective action .

The immunosuppressive effect is provided by a decrease in the release rate of cytokines (interferon gamma, interleukin-1,2) from macrophages and lymphocytes. The drug inhibits the secretion and synthesis of ACTH, secondarily inhibits the process of synthesizing endogenous glucocorticosteroids. Under the action of the drug, the likelihood of scar formation decreases due to the inhibition of the rate of connective tissue reactions during inflammation. You can buy Diprospan in the form of suspensions and injections.

Indications for use Diprospan

What is Diprospan medicine for?

Indications for the use of Diprospan injections are as follows: the drug is prescribed for shock (toxic, cardiogenic, surgical, burn, traumatic), with anaphylactoid reactions , transfusion shock, allergic reactions, status asthmaticus, severe course, at cerebral edema (after radiation therapy, after surgical interventions), with acute adrenal insufficiency. Also indications for use are: systemic connective tissue pathology (, SLE), poisoning with caustic fluids (prevention of the formation of cicatricial constrictions and a decrease in the severity of inflammation), hepatic coma , acute hepatitis, thyrotoxic crisis . Blockades with Diprospan are often put.

Contraindications for Diprospan

Instructions for use Diprospan does not recommend prescribing the drug intraarticularly with pathological bleeding, with periarticular infections , with septic and infectious lesions of the joint, with a pronounced form of periarticular, with common infectious diseases, with intra-articular fracture of the bone, after arthroplasty , with severe bone destruction, with a “dry” joint, with no signs of synovitis, with joint instability after arthritis, with aseptic necrosis the epiphyses of the bones that form the joint.

In case of severe infectious diseases the drug can be prescribed only with simultaneous specific therapy. medicinal product not used for diseases of the digestive tract:, peptic ulcer digestive system, esophagitis , intestinal anastomosis, peptic ulcer, ulcerative . Betamethasone is not prescribed in the post-vaccination period, with after the vaccine . The drug is contraindicated for use in , , with recently transferred, with decompensated form of CHF, with Itsenko-Cushing's disease , at , at nephrourolithiasis , severe pathology liver and kidneys, with obesity, myasthenia gravis, systemic osteoporosis, with hypoalbuminemia, with acute psychosis , (closed and open-angle forms), during pregnancy, during breastfeeding.

A contraindication to Diprospan is hypersensitivity to betamethasone .

Side effects of Diprospan

Side effects from the use of the drug Diprospan depend on the possibility of compliance with the circadian treatment regimen, dosage and duration of the drug. Endocrine system: manifestation of latent diabetes mellitus, "steroid" diabetes, delayed sexual development in children, Itsenko-Cushing's syndrome (myasthenia gravis, amenorrhea, striae, hirsutism , obesity of the pituitary type, moon face, increased , hirsutism). digestive tract: loss of appetite, "steroid" ulcer gastrointestinal system, vomiting, nausea, increased levels of enzymes of the hepatic system. The cardiovascular system: the formation of thrombosis, hypercoagulation , increased severity of CHF, bradycardia,. Nervous system: convulsions, headaches, cerebellar pseudotumor, delirium, vertigo, dizziness, insomnia, nervousness, increased levels, depression.

Description side effects Diprospana on sense organs: posterior subcapsular, sudden loss of vision, trophic changes in the cornea, increased intraocular pressure. Metabolism: increased sweating, increased protein breakdown, negative nitrogen balance, weight gain, hypocalcemia, increased excretion of calcium ions from the body. Musculoskeletal system: osteoporosis, atrophy and loss of muscle mass, "steroid" myopathy , rupture of muscle tendons, slowing down the processes of ossification and growth of the skeletal system in children as a result of premature closure of the epiphyseal growth zones. Skin covers: tendency to develop candidiasis and pyoderma, steroid acne, pigmentation disorders, thinning of the skin, formation ecchymosis and petechiae, slowing wound healing. It is possible to form leukocyturia . With intravenous administration, convulsions, "tides" of blood flow to the face, arrhythmias are possible.

Diprospan injections, instructions for use

Dosing regimen betamethasone and the method of administration is selected depending on the nature and severity of the underlying disease.

According to the instructions for use Diprospan infusion solution before administration, dilute in a solution of sodium chloride 0.9%, or in a solution of dextrose. You can enter only freshly prepared solution. Diprospan injections are done deep intramuscularly at a dose of 4-8 mg in severe pathology.

Periarticular and intra-articular injections of the drug are carried out in very large joints at a dose of 4-8 mg. An injection into the joint directly allows you to achieve a more effective effect on inflammatory process in him. Injections are also made in the knee, however, it is better to entrust such injections to doctors, as this is a complex process.

At skin diseases the drug is injected into the wound or intradermally at a dose of 0.2 ml/square centimeter.

When local infiltration is carried out: 1-2 mg. If necessary, the drug can be administered subconjunctivally at a dose of 2 mg.

When using the medication, it is very important to consider contraindications.

The tool is not available in the form of ointments and tablets.

How many times can you inject and how often?

It is better to consult with your doctor about this, who will select the dose you need. Uncontrolled use of the drug adversely affects the state of the body.

Overdose

The annotation states that overdose is manifested by sleep disturbance, vomiting, nausea, depression, agitation, euphoria . Prolonged use in large quantities causes the formation of secondary adrenal insufficiency , increased blood pressure, fluid retention in the body, osteoporosis. Requires the use of aminoglutethimide, antacids, correction electrolyte balance .

Interaction

Diprospan reduces efficiency anticoagulants , insulin, antihypertensive drugs, oral hypoglycemic drugs. The drug weakens the activity of vaccines, the action diuretics . The use of barbiturates, phenytoin, weakens the effect of the drug. The risk of side effects increases with treatment antipsychotics, estrogens, androgens, NSAIDs, immunosuppressants , ritodrine, digitalis glycosides, nitrates, tricyclic antidepressants . Diprospan enhances the severity of the hepatotoxic effects of paracetamol. Carbonic anhydrase inhibitors and increase the risk of osteoporosis. The drug slows down the metabolic process and increases its toxicity, enhances the metabolism of mexiletine, isoniazid, increases the concentration. The drug reduces the effectiveness growth hormone .

Terms of sale

Requires a prescription.

Storage conditions

In a dark place inaccessible to children at a temperature of 2-25 degrees Celsius. Avoid freezing. Shake before use.

Best before date

Not more than 3 years.

special instructions

Diprospan can be mixed in solutions local anesthetics in equal volumes. It is unacceptable to use the drug in therapy hyaline membrane disease in newborns. The drug should not be injected into the intervertebral spaces, into infected areas and unstable joints. Before starting treatment, it is mandatory to conduct an examination: a complete blood count, blood glucose, electrolytes. With concomitant, sepsis, intercurrent infections, they are simultaneously administered. Reviews of the drug indicate the high effectiveness of the drug, subject to all recommendations. It is important to take into account that in patients with hypothyroidism, the clearance of glucocorticosteroids decreases, with thyrotoxicosis the opposite effect is recorded.