Cordaflex analogs instructions for use. Cordaflex - a medicine for the treatment of cardiovascular disorders

Coated tablets contain 10 mg nifedipine in each as active substance. For excipients: polyvinyl butyral in an amount of 0.7 mg; talc (1 mg); 0.3 mg magnesium stearate ; 4 mg hydroxypropylcellulose ; lactose monohydrate (15 mg); croscarmellose sodium (13 mg); microcellulose (46 mg). The shell consists of hypromellose - 2.63 mg; titanium dioxide C.I. 77891 - 0.82 mg; yellow iron oxide - 0.3 mg and magnesium stearate - 0.25 mg.

Long-acting tablets with film-coated contain the same active substance, but in a dose of 20 mg. Each of them contains the following substances as auxiliary substances: microcellulose (99 mg); lactose monohydrate (30 mg); croscarmellose sodium (26 mg); copolymers of methyl methacrylate and ethyl methacrylate in a ratio of 1:2 (1.9 mg); talc (2 mg); magnesium stearate (0.6 mg); hyprolose (0.5 mg). The film casing is made of hypromellose - 5.26 mg; titanium dioxide - 1.64 mg; red iron oxide - 0.6 mg; magnesium stearate - 0.5 mg.

Release form

There are two options for the release form of the drug:

• Coated tablets, weighing 10 mg. Every 100 tablets are placed in a brown glass bottle. The bottles are packed individually in cardboard boxes.
• Film-coated tablets, having a prolonged action. Each tablet weighs 20 mg. Place 30 or 60 tablets in brown glass bottles. The bottles must be sealed with polyethylene caps that have a first-opening control. The bottle is packed in a cardboard box.

pharmachologic effect

Contraindications

Contraindications are:

• intolerance nifedipine , other derivatives 1,4-dihydropyridine , additional components included in the tablets;
• arterial hypotension ;
• Not stable angina ;
• the presence at the moment or very recently of acute, pronounced aortic stenosis ;
• idiopathic sub aortic stenosis ;
• chronic heart failure during the period of decompensation;
• childhood.

It is prescribed with extreme caution to elderly patients, those with impaired renal function, and patients.

Side effects

Cordaflex is usually well tolerated. Side effects appear rarely, more often at the beginning of treatment (then they may become weaker or disappear).

There are such side effects:

• On the heart and blood vessels: lowering blood pressure, hyperemia face and torso, swelling in the limbs , acceleration heart rate, paradoxical angina attack , development acute heart failure .
• On nervous system : increased fatigue , emotional lability , sleep disorders, headache, .
• On the gastrointestinal tract: occurrence, nausea , vomit , stool disorders, dryness or inflammation of the oral mucosa, intrahepatic cholestasis , as well as increased activity of certain liver enzymes.
• On the circulatory system: thrombocytopenia , leukopenia , anemia .
• On urinary system : increased daily diuresis, decreased renal function.

There may be allergic reactions as , exanthema , .

Instructions for use of Cordaflex (Method and dosage)

The drug is taken orally. 10 mg film-coated tablets are swallowed whole before meals with water.

The dosage is set individually, as it very much depends on the severity of the disease, the type of disease and the body’s response to the therapy. Start with 1 tablet (10 mg) 3 times a day. There should be at least 2 hours between doses of the drug. Maximum dose per day - 40 mg.

Long-acting film-coated tablets are swallowed whole and washed down with water. In this case, the initial dose is 1 tablet 2 times a day. In any case, the daily dose is divided into 2 doses, between which a 12-hour interval must be observed.

According to the instructions for use of Cordaflex, discontinuation of the drug should be carried out gradually.

Overdose

In case of overdose nifedipine the following consequences may occur:

• arterial hypotension ;
• pain behind the sternum (like an attack angina pectoris );
• loss of consciousness;
• collapse ;
• ventricular or nodular extrasystole ;
• bradycardia .

Interaction

Cordaflex should not be administered with alcohol-containing medications.

Possible development orthostatic hypotension when used with methyldopa , , and also with And octadine .

Cimetidine ,

Analogues of the drug Cordaflex are presented, in accordance with medical terminology, called “synonyms” - drugs that are interchangeable in their effects on the body, containing one or more identical active ingredients. When selecting synonyms, consider not only their cost, but also the country of production and the reputation of the manufacturer.

Description of the drug

Nifedipine reduces the flow of extracellular calcium ions into cardiomyocytes and smooth muscle cells of the coronary and peripheral arteries. In therapeutic doses, it normalizes the transmembrane current of calcium ions, disturbed by a number of pathological conditions, especially when arterial hypertension. Reduces spasm and dilates coronary and peripheral arterial vessels, reduces total peripheral resistance, reduces afterload and myocardial oxygen demand. At the same time, it improves blood supply to ischemic areas of the myocardium without the development of “steal” syndrome, and also increases the number of functioning collaterals.

Nifedipine has virtually no effect on the sinoatrial and atrioventricular nodes and does not have an antiarrhythmic effect. Does not affect the tone of the veins. Nifedipine increases renal blood flow, causing moderate natriuresis. IN high doses inhibits the release of calcium ions from intracellular stores. Reduces the number of functioning calcium channels without affecting the time of their activation, inactivation and recovery.

List of analogues

Note! The list contains synonyms Cordaflex having similar composition, so you can choose a replacement yourself, taking into account the form and dose of the medicine prescribed by your doctor. Give preference to manufacturers from the USA, Japan, Western Europe, as well as well-known companies from of Eastern Europe: KRKA, Gedeon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Reviews

Visitor survey results

Four visitors reported effectiveness

Two visitors reported cost estimates

Seven visitors reported frequency of intake per day

One visitor reported an expiration date

Two visitors reported reception times

37 visitors reported the patient's age

Visitor reviews

Official instructions for use

NIFEDIPINE

Pharmacological properties

Indications for use

Contraindications

Directions for use and doses

Side effects

Interaction with other drugs

Release form

Storage conditions

Best before date

Vacation conditions

The information on the page was verified by physician-therapist E.I. Vasilyeva.

Cordaflex is a complex antihypertensive and antianginal drug that helps to effectively cope with high blood pressure.

After internal reception given medication there is a fairly rapid expansion of coronary and peripheral blood vessels, which can effectively reduce high blood pressure.

Main operating medicinal substance Cordaflexa is Nifedipine, which has pronounced antihypertensive properties.

After internal administration, the hypotensive effect, as a rule, develops within 20-25 minutes. and continues for 12-24 hours.

Most often, this drug is well tolerated by patients of all ages.

Main indications for use of Cordaflex:

• IHD (coronary heart disease);
• Raynaud's syndrome;
• angina ( painful sensations in the area of ​​the heart).

Attention: Before starting to use Cordaflex, it is recommended to consult with a qualified cardiologist or therapist!

The drug is available in the form of soluble tablets for internal use.

How to drink Cordaflex?

The initial daily dose of this medicinal product is 1 t. (10 mg.) 2-3 r. the day before meals, drinking sufficient quantity water. The minimum interval between doses of Cordaflex should be 2-3 hours.

The course of treatment and dose of the drug is selected by the attending physician absolutely individually for each patient, depending on the severity of the particular disease.

The maximum daily dose of the drug should not exceed more than 4 tons (40 mg) as this may adversely affect general condition body.

For elderly patients, an initial daily dose of 5 mg is recommended. (1/2 t.) 2-3 r. per day, preferably 15-20 minutes. before meals, drink plenty of water.

Contraindications to the use of Cordaflex

• hypersensitivity (increased sensitivity of the body to the main active ingredients of the drug);
• age under 18 years;
• arterial hypotension (low blood pressure);
• cardiogenic shock;
• severe heart failure;
• pregnancy and lactation (breastfeeding);
• acute myocardial infarction;
• tachycardia (rapid heartbeat).

Side effects of Cordaflex

• headache;
• severe arterial hypotension;
• periodic dizziness;
• sleep disturbance (insomnia);
• indigestion (

Country of origin

Product group

Calcium channel blocker

Release forms

• 30 or 60 tablets in brown glass bottles, sealed with polyethylene caps with first opening control and equipped with an accordion shock absorber. 1 bottle along with instructions for use is packed in a cardboard box. 30 tablets in brown glass bottles, sealed with polyethylene caps with first opening control and equipped with an accordion shock absorber. 1 bottle along with instructions for use is packed in a cardboard box. Controlled-release film-coated tablets 40 mg. 10 tablets in a blister made of PVC/PVDC/alfoil. 1 or 3 blisters in a cardboard box along with instructions for use. Film-coated tablets, 10 mg. 100 tablets in a brown glass bottle. 1 bottle is placed in a cardboard box along with instructions for use.

Description of the dosage form

• : round, biconvex, film-coated tablets, brownish-red in color, beveled, odorless. biconvex round tablets, film-coated, brownish purple with a matte or slightly shiny surface. Odorless or with a weak characteristic odor. Broken appearance: yellow along the edges with a narrow stripe of brownish-violet color. Biconvex round tablets, coated with a matte or slightly shiny coating, yellow in color, with a slight characteristic odor.

pharmachologic effect

Pharmacokinetics

Special conditions

Compound

• 1 tablet contains: active ingredient - nifedipine 20 mg, Excipients: tablet core: microcrystalline cellulose 99 mg, lactose monohydrate 30 mg, croscarmellose sodium 26 mg, methyl methacrylate and ethyl acrylate copolymer 1.9 mg, talc 2 mg, magnesium stearate 0.6 mg, hyprolose 0.5 mg; tablet shell: hypromellose 5.26 mg, titanium dioxide 1.64 mg, red iron oxide dye (E 172) 0.6 mg, magnesium stearate 0.5 mg. : 1 tablet contains 40 mg of the active substance - nifedipine, as well as excipients: cellulose, microcrystalline cellulose, lactose, hypromellose 4000, magnesium stearate, colloidal anhydrous silicon dioxide. The tablet shell contains: hypromellose 15, macrogol 6000, macrogol 400, red iron oxide E 172, titanium dioxide E 171, talc. : 1 tablet contains: active ingredient - nifedipine 20 mg, excipients: tablet core: microcrystalline cellulose 99 mg, lactose monohydrate 30 mg, croscarmellose sodium 26 mg, methyl methacrylate and ethyl acrylate copolymer 1.9 mg, talc 2 mg, magnesium stearate 0, 6 mg, hyprolose 0.5 mg; tablet shell: hypromellose 5.26 mg, titanium dioxide 1.64 mg, red iron oxide dye (E 172) 0.6 mg, magnesium stearate 0.5 mg. Each film-coated tablet contains active substance: nifedipine 10 mg, as well as excipients: polyvinyl butyral, magnesium stearate, talc, hydroxypropyl cellulose, croscarmellose sodium, lactose monohydrate, microcrystalline cellulose, titanium dioxide, yellow iron oxide, hypromellose.

Cordaflex indications for use

• Arterial hypertension, including hypertensive crises Ischemic disease heart: stable angina (effort angina), vasospastic angina (Prinzmetal angina)

Cordaflex contraindications

• - acute stage of myocardial infarction; - cardiogenic shock; - severe arterial hypotension (systolic blood pressure below 90 mm Hg); - severe aortic or mitral stenosis, idiopathic hypertrophic subaortic stenosis; - severe heart failure; - I trimester of pregnancy; - lactation period ( breastfeeding); - children's and adolescence up to 18 years old; - hypersensitivity to nifedipine and other components of the drug. Cordaflex® should be used with caution in chronic heart failure, hypertrophic obstructive cardiomyopathy, severe cerebrovascular accidents, CVS, severe tachycardia, severe liver and/or kidney dysfunction, malignant arterial hypertension, in patients on hemodialysis (due to the risk the occurrence of severe arterial hypotension against the background of peripheral vasodilation), with lactose intolerance, as well as in elderly patients.

Cordaflex dosage

• 10 mg 10 mg, 5 mg 20 mg 20 mg 40 mg

Cordaflex side effects

• The frequency of side effects is adjusted to the following categories: very common (? 1/10); often (?1/100 -

Drug interactions