Does isoprinosine have a diuretic effect? Indications for use of Isoprinosine

Isoprinosine is a drug with immunomodulatory and antiviral effects.

Release form and composition

Isoprinosine is produced in the form of tablets (oblong, white or almost white, with a slight amine odor, biconvex, with a score on one side), 10 pieces each. in blisters, 2, 3, 5 blisters in cardboard packs.

1 tablet contains 500 mg active substance– inosine pranobex.

Auxiliary components included in the drug: povidone, mannitol, wheat starch, magnesium stearate.

Indications for use

Isoprinosine is prescribed for the treatment of:

• Flu and other acute respiratory viral infections;
• Infections caused by a virus Herpes simplex types 1, 2, 3 and 4: genital and labial herpes, herpetic keratitis, herpes zoster, chickenpox, infectious mononucleosis caused by the Epstein-Barr virus;
• Severe measles;
• Cytomegalovirus infection;
• Molluscum contagiosum;
• Human papillomavirus infection: laryngeal papillomas and vocal cords(fibrous type), papillomavirus infection of the genitals in women and men, warts.

Contraindications

The use of Isoprinosine is contraindicated in:

• Gout;
• Urolithiasis;
• Chronic renal failure;
• Arrhythmias;
• Hypersensitivity to the components of the drug.

The drug is not prescribed:

• Children under 3 years old or weighing up to 15-20 kg;
• Nursing and pregnant women.

Directions for use and dosage

Isoprinosine is taken orally after meals. Typically, adults and children over 3 years of age (with a body weight of 15-20 kg) are prescribed 50 mg/kg per day, the frequency of dosing is 3-4 times a day. At severe forms infectious diseases the dosage can be individually increased to 100 mg/kg per day, the frequency of administration is up to 6 times a day.

Maximum daily dose is:

• Adults – 3-4 g;
• Children – 50 mg/kg.

The duration of therapy in adults and children for acute diseases is usually 5-14 days. Treatment should be continued for another 2 days from the moment of disappearance clinical symptoms. Under the supervision of a doctor, the duration of treatment can be increased individually if necessary.

Treatment of chronic recurrent diseases of adults and children can be carried out in several courses of 5-10 days with an interval of 8 days.

During maintenance therapy, the dosage can be reduced to 0.5-1 g per day (1-2 tablets) for a month.

At herpetic infection For adults and children, the drug is usually prescribed for 5-10 days until signs of the disease disappear, in asymptomatic period to reduce the number of relapses, take 1 tablet 2 times a day for a month.

For adults with human papillomavirus infection, Isoprinosine as monotherapy is prescribed 2 tablets 3 times a day, for children - 1/2 tablet per 5 kg of body weight per day in 3-4 doses. Duration of therapy is 14-28 days. For recurrent genital warts the drug is prescribed in the same dosage. It is taken for 14-28 days as monotherapy or in combination with surgical treatment. The course is repeated 3 times at intervals of 1 month.

For cervical dysplasia associated with the human papilloma virus, Isoprinosine is prescribed 3 times a day, 2 tablets for 10 days, after which the course is repeated 2-3 times with an interval of 10-14 days.

Side effects

When using Isoprinosine, it is possible to develop side effects that occur with varying frequency:

• Nervous system: headache, dizziness, fatigue, feeling unwell(often); nervousness, drowsiness, insomnia (uncommon);
• Musculoskeletal system: joint pain, exacerbation of gout (often);
• Hepatobiliary system: increased activity of liver enzymes, alkaline phosphatase (often);
• Gastrointestinal tract: decreased appetite, nausea, vomiting, epigastric pain (often); diarrhea, constipation (infrequently);
• Kidneys and urinary tract: polyuria (uncommon);
• Skin and subcutaneous fat: itching, rash (often);
• Other: increased blood urea nitrogen concentration (often).

From allergic reactions the most likely development is maculopapular rash, urticaria and angioedema.

special instructions

Isoprinosine should be taken with caution concomitantly with diuretics, xanthine oxidase inhibitors, zidovudine, and in acute renal failure.

The drug for acute viral infections is most effective in cases where treatment is started at early stage illness (better from the first day).

Since Isoprinosine is excreted from the body in the form uric acid, with prolonged use, it is recommended to periodically monitor the concentration of uric acid in urine and blood serum. Patients with significant increased concentration uric acid in the body, you can simultaneously take medications that reduce its concentration. Monitoring is also necessary when taking Isoprinosine concomitantly with drugs that impair renal function and medicines, increasing the concentration of uric acid.

Use the drug with caution in patients with acute liver failure, since it undergoes metabolism in the liver. In this regard, patients with liver failure need to monitor the level of uric acid in urine and blood serum every 2 weeks. During long courses of treatment, it is recommended to monitor the activity of liver enzymes every month. 4.84 Rating: 4.8 - 25 votes

At modern treatment many diseases with viral nature origin, doctors widely use Isoprinosine, synthesized in the late 70s of the last century. In Russia, the drug is used for therapy and prevention viral infections a little less than 20 years old. In addition to antiviral activity, Isoprinosine has immunomodulatory properties, which greatly expands the scope of its use and makes drug analogues less effective in the treatment of severe viral diseases. Instructions for necessary application contains all the necessary information about the composition of the medicine, indications for use, dosage and possible side effects. The price of the drug in Russia varies from 500 to 1500 rubles.

Composition, mechanism of action and application

The drug Isoprinosine is available in one single dosage form– in tablets, the medicine package can contain 20, 30 or 50 pieces. The main active ingredient of Isoprinosine is the synthetically produced inosine pranobex, a substance of animal origin. The main function of inosine is considered to enhance biochemical reactions in the body, due to which the drug has the following mechanism of action:

• Increases the activity of T-lymphocytes - the main cells immune system any person.
• Strengthens the production of interferon.
• It disrupts the chain of virus formation in the body, blocks the production of enzymes necessary to activate pathogenic microorganisms.

Isoprinosine, used in a course, increases the body's resistance to bacteria and pathogenic viruses, which makes it possible to increase resistance to infections. The drug is prescribed as part of complex therapy when identifying ailments such as:

• Flu, frequent respiratory infections.
• HPV, manifested by genital condylomas and warts.
• Diseases caused by the herpes virus different types, including herpes zoster, herpetic keratitis, genital herpes, chicken pox.
• Cytomegalovirus infection.
• Measles.

In combination with interferon drugs and others antiviral drugs, the effectiveness of Isoprinosine increases many times over. When choosing antiviral agents it is necessary to listen to the opinion of qualified doctors, since only correct selection treatment regimens will help you safely cope with the disease. For some diseases, Isoprinosine is contraindicated, and then analogues with the appropriate mechanism of action are selected. Maximum concentration The accepted dose of the drug in the blood is achieved in two hours, the bioavailability of the drug is 90%. Accumulation active substance in the body is excluded, after absorption medicinal base Isoprinosine is eliminated from the body for no longer than two days.

Isoprinosine is a highly effective drug against the human papillomavirus, which can be transmitted through sexual contact and at home. The treatment regimen for detected HPV is selected based on the strain of the virus, the general state of the immune system, and the severity of the infection. HPV, as well as the herpes virus, can never be completely removed from the body with any treatment regimen. At modern level Pharmacology still has to admit this fact. The drug Isoprinosine helps reduce the severity clinical manifestations HPV, herpes, prolongs periods of remission, helps in eliminating warts and condylomas.

Viral respiratory diseases in people with high immunity occur without severe symptoms and without complications. Indications for the use of Isoprinosine in the treatment of acute respiratory viral infections, tonsillitis, tonsillitis, and rhinitis are considered to be conditions in which one’s own immunity cannot completely cope with the disease. Isoprinosine increases resistance protective forces, medicine is especially necessary when choosing a treatment regimen for frequently ill children.

The effectiveness of the use of Isoprinosine in the treatment of chickenpox has been proven. Chickenpox in young children is usually mild, and all signs of the disease disappear within a few days. In older children with weakened immune systems, chickenpox causes fever and symptoms of intoxication. Instructions for use of Isoprinosine indicate that prescribing medication for chickenpox reduces the duration of the disease, prevents fever, improves general state, reduces skin rashes and itching.

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Dosage and course of treatment with Isoprinosine

The course of treatment with the drug and the recommended dosage are calculated based on the type of virus. For acute respiratory diseases Isoprinosine is prescribed in a daily dosage of 50 mg per kilogram of body weight. This amounts to approximately 8 tablets per day for adults. Isoprinosine is prescribed to children from the age of three, the daily dosage is half a whole tablet for every 5 kg of total weight. The resulting value is divided into three or four steps. The duration of taking the drug continues until the clinical symptoms disappear respiratory infections and two more days to fully consolidate the result. For recurrent forms viral diseases repeated courses of up to 10 days of medication are indicated; the break between doses should be more than 8 days. For herpetic infections in children and adults, Isoprinosine is used for up to 10 days in the acute period and for a month after the disease, 1-2 tablets to prevent relapses.

HPV can cause not only the appearance of condylomas on the mucous membranes of the genital organs, but also warts. Single formations go away on their own within a few months and do not cause much concern. But some people HPV causes the appearance multiple papillomas and warts, which requires the use of highly effective therapy. Isoprinosine, when HPV is detected as part of complex therapy, reduces viral activity, increases the functioning of the immune system, this effect of the drug allows minimum terms get rid of skin neoplasms. Adults with HPV Isoprinosine two tablets are prescribed up to three times a day, therapy lasts up to a month.

The use of antiviral therapy is indicated during the use of surgical or other removal of papillomas and warts. Isoprinosine tablets with this therapy suppress the activity of the virus and do not allow new growths to appear on the skin and mucous membranes. With dysplasia on the cervix and with detected HPV drug prescribed for several courses at intervals of two weeks.

The instructions for use of the drug should not be a guide to the uncontrolled use of the drug. The necessary effect of Isoprinosine will appear only if it is prescribed correctly, which can be provided by a doctor after a comprehensive examination of the patient. An antiviral drug for HPV, herpes, warts will bring undoubted benefit during the entire course of therapy. There are also contraindications for which Isoprinosine is not used; if they are identified, analogues are selected.

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Contraindications to the use of Isoprinosine

Isoprinosine instructions indicate several diseases for which the drug is not used. These include:

1. Gout.
2. Urolithiasis.
3. Cardiac arrhythmia.
4. Kidney failure.
5. Age up to three years or low body weight of the child, not exceeding 15-20 kg.

Isoprinosine is not used during pregnancy, as appropriate tests have not been conducted. In some people, the drug can cause disorders of the housing and communal services, headaches, inflammation of the joints, itchy skin. If you are intolerant to the drug, analogues are selected, these include Groprinosin, Immunosin, their price is an order of magnitude lower. Isoprinosine analogues with a gentle effect on the body are recommended to be selected for elderly patients.

Isoprinosine and alcohol, like any other drug, are not compatible. Alcohol-containing drinks undergo filtration in the liver, which significantly increases the load on this organ, therefore, when treated with antiviral drugs with simultaneous administration strong drinks risk of development adverse reactions increases many times over. Isoprinosine and alcohol are highly not recommended to be combined in case of urolithiasis, impaired renal function, this will not only reduce the effectiveness of the therapy, but can also lead to severe allergic symptoms, up to Quincke's edema.

Comments

Megan92 () 2 weeks ago

Has anyone managed to get rid of papillomas in their armpits? They really bother me, especially when you sweat.

Daria () 2 weeks ago

I have already tried so many things and only after reading this article, I was able to get rid of papillomas in the armpits (and on a very budget).

P.S. Only I’m from the city and couldn’t find it on sale here, so I ordered it online.

Megan92 () 13 days ago

Daria () 12 days ago

megan92, that’s what I wrote in my first comment) I’ll duplicate it just in case - link to article.

Sonya 10 days ago

Isn't this a scam? Why do they sell on the Internet?

Yulek26 (Tver) 10 days ago

Sonya, what country do you live in? They sell it on the Internet because stores and pharmacies charge outrageous markups. In addition, payment is only after receipt, that is, they first looked, checked and only then paid. And now they sell everything on the Internet - from clothes to TVs and furniture.

Editor's response 10 days ago

Sonya, hello. This drug for the treatment of papillomavirus infection is really not implemented through pharmacy chain and retail stores to avoid overpricing. Currently you can only order from official website. Be healthy!

Sonya 10 days ago

I apologize, I didn’t notice the information about cash on delivery at first. Then everything is fine if payment is made upon receipt.

Margo (Ulyanovsk) 8 days ago

Has anyone tried it? traditional methods to get rid of warts and papillomas?

Andrey A week ago

I tried to burn off a wart on my head with vinegar. The wart really went away, only in its place there was such a burn that my finger hurt for another month. And the most annoying thing is that after a month and a half, two more warts popped up nearby ((

Ekaterina A week ago

I tried to burn out the papilloma with celandine - it didn’t help, it just turned black and became so scary (((

Maria 5 days ago

I recently watched a program on Channel One, they also talked about this PAPIFEX. Many doctors recommended for treatment. I ordered it, I use it, and indeed, the papillomas are dissolving one by one, there are only 2 left, the most tenacious ones.

Composition, release forms and names of Isoprinosine

Isoprinosine tablets contain the following substances as auxiliary components:

• Mannitol;
• Wheat starch;
• Magnesium stearate.

In everyday speech, qualified names are often used to refer to this drug, such as Isoprinosine 500, Isoprinosine 50, Isoprinosine 30 etc. In these names, the number 500 means dosage active component drug. And the numbers 30 and 50 mean the number of tablets in the package. Such markings allow doctors, pharmacists and patients to quickly understand exactly how many tablets are needed.

Therapeutic effect

Stimulation of the immune system by Isoprinosine occurs due to the activation of the production of interleukins 1 and 2, as well as interferon gamma, which have anti-inflammatory activity. In addition, the production of interleukins 4 and 10 decreases, which, on the contrary, maintain and enhance inflammation in various organs and fabrics. As a result of this modulation of the production of interleukins and interferon, the intensity inflammatory process in any tissue or organ decreases, as a result of which the lesion decreases and recovery occurs normal structure cells.

In addition, Isoprinosine activates the work of cytotoxic T-lymphocytes and natural killer cells (NK cells), which destroy cells damaged by viruses, which also leads to a reduction in the size of the inflammatory focus and restoration of the structure of an organ or tissue. In parallel with the increase in the activity of cytotoxic T-lymphocytes and NK cells under the influence of Isoprinosine, there is an increase in the production of T-suppressors and T-helpers, which help other cells of the immune system to “recognize” and destroy viruses or cellular structures affected by them. Separately, it should be noted that under the influence of Isoprinosine, the production of IgG antibodies increases, which also contribute to the destruction of virus-infected cells.

All of the listed components of activation of the immune system (increased activity of cytotoxic T-lymphocytes, NK-cells, T-helpers, T-suppressors, as well as the production of IgG, interleukins 1 and 2 and interferon gamma), aimed at destroying viruses, are implemented in the systemic bloodstream. That is, all these cells and substances end up in the blood, which flows to the affected organ or tissue. And when the blood flow delivers all the listed cells and substances to the required area, they are released and penetrate into the thickness of the tissue, where they exert their effect.

In addition to reactions of activation of the immune system that occur in the bloodstream, there are other processes that occur directly in the thickness of the affected tissues or on the mucous membranes. The reactions of the immune system in the thickness of tissues and on mucous membranes are called local immunity, and represent a very important link in general mechanism destruction of viruses and cells affected by them. After all local immunity destroys viruses and affected cells constantly, without waiting for a massive reaction in the systemic bloodstream and, thus, prevents pathogenic microorganisms from quickly infecting large plot tissue or organ. Under the influence of Isoprinosine, local immunity is activated, which is manifested by the accumulation large quantity monocytes, macrophages and neutrophils in the affected area of ​​the organ, which destroy cells infected with viruses.

The direct effect of Isoprinosine on viruses is that the drug suppresses their reproduction by blocking the enzyme. dihydropteroate synthetase. In laboratory experiments Isoprinosine successfully inhibits the reproduction of the following viruses:

• Herpes simplex types 1 and 2;
• Cytomegalovirus;
• Measles virus;
• Human T-cell lymphoma virus type III;
• Polioviruses;
• Influenza viruses types A and B;
• ECHO virus (human enterocytopathogenic virus);
• Encephalomyelocarditis virus;
• Equine encephalitis virus.

Indications for use

• Influenza and other acute respiratory viral infections;
• Herpetic infections caused by Herpes simplex viruses types 1, 2, 3 and 4 (labial and genital herpes, herpes keratitis);
• Herpes infections caused by a virus Varicella zoster– chicken pox and herpes zoster;
• Cytomegalovirus infection;
• Infections caused by the Epstein-Barr virus (infectious mononucleosis);
• Human papillomavirus infection in various manifestations, such as papillomas of the larynx, vocal cords, genital organs in men and women, as well as genital warts and warts of any localization;
• Molluscum contagiosum;
• Measles.

Isoprinosine - instructions for use

Dosage calculation for children and adults

• – the dosage is calculated individually according to body weight, based on the ratio of 50 mg per 1 kg of weight per day. That is, if an adult’s body weight is 70 kg, then the daily dosage of Isoprinosine for him is 70 * 50 = 3500 mg, which corresponds to 7 tablets (3500/500). This calculated number of tablets is divided into 3 to 4 doses per day. Adults may not calculate the dosage of Isoprinosine individually, based on the fact that the average daily dose of Isoprinosine for a person with normal body weight (60–80 kg) is 6–8 tablets. In addition, you can use a simplified version of calculating the daily dosage of Isoprinosine - 1 tablet for every 10 kg of weight.
• Children 3 – 11 years old– the dosage is calculated individually according to body weight, based on the ratio of one tablet for every 10 kg of weight per day. That is, if a child’s body weight is 35 kg, then he should take 3.5 Isoprinosine tablets per day. The total daily amount of the drug for children is divided into 3–4 doses.

For children aged 3 to 11 years, the maximum daily dosage of Isoprinosine should not exceed the ratio of 50 mg per 1 kg of weight, regardless of the severity of the disease. For example, if a child weighs 20 kg, then he needs to take 2 tablets per day, which is 1000 mg. To check whether a given dosage does not exceed the maximum allowable, you should divide it by the child’s body weight - in our example, 1000/20 = 50. Then the resulting figure must be compared with 50, and if it is less, it means that the dosage is below the maximum permissible norm. If the resulting figure is more than 50, then the dosage of Isoprinosine is greater than the maximum allowable norm for a child. In this case, the dosage should be reduced. In our example, the calculated dosage is equal to the maximum permissible for a child, so it can be used.

Elderly people (over 65 years of age) should take Isoprinosine at normal adult dosages without reducing them.

The duration of use of Isoprinosine in individually calculated dosages is entirely determined by the type of disease.

Reception for acute acute respiratory viral infections, influenza, measles, molluscum contagiosum and infectious mononucleosis

Use for chronic diseases with recurring exacerbations (genital and labial herpes, herpes zoster, infection caused by cytomegalovirus)

In addition, it is possible to use another treatment regimen, which consists of taking Isoprinosine in an age-specific individual dosage until the symptoms of exacerbation of the disease completely disappear. Then the drug should be continued to be taken at the same dosage for another two weeks, which is necessary to achieve stable remission.

Reception for any herpetic infection (chickenpox, herpes keratitis, genital or labial herpes, herpes zoster)

Reception for papillomas of any localization, human papillomavirus infection or genital warts

• Adults and teenagers over 12 years old – take 2 tablets 3 times a day.
• Children 3 – 11 years old – daily dosage Isoprinosine is calculated individually according to the ratio: one tablet for every 10 kg of the child’s weight. The calculated total dosage of the drug is divided into 3–4 doses per day and given to the child for 14–28 days.

Isoprinosine for HPV

Use during pregnancy and breastfeeding

special instructions

At long-term use Isoprinosine should be monitored every 4 weeks cellular composition peripheral blood by calculating the leukoformula as part of a general blood test, and also monitor the functioning of the liver and kidneys, determining the activity of AST and ALT, as well as the concentrations of creatinine and uric acid in the blood.

In addition, it is necessary to frequently (at least once a week) monitor the concentration of uric acid in the blood when using Isoprinosine concomitantly with drugs that impair kidney function or promote the accumulation of uric acid.

Impact on the ability to operate machinery

Overdose

Interaction with other drugs

Drugs from the groups of xanthine oxidase inhibitors (for example, Allopurinol, Zilorik, Milurit, Purinol, Allopin, etc.) and uricosuric drugs (salicylates, including Aspirin, Probenecid, Benemid, Sulfinpyrazone, diuretics, etc.) increase the risk of increasing urinary concentrations acids in the blood and the development of gout.

With the simultaneous use of Isoprinosine with Acyclovir and Zidovudine, the antiviral effect of the latter is enhanced.

Isoprinosine for children

As a rule, the drug is used for children to treat acute viral infections (ARVI, influenza, measles, chickenpox, molluscum contagiosum, infectious mononucleosis) or recurrent diseases associated with the herpes virus (for example, herpes on the lip, etc.). IN general case It is recommended to give the child Isoprinosine for 5 to 15 days, depending on the severity of the infection and the speed of disappearance of symptoms. In this case, it is necessary to use the rule that for acute diseases, Isoprinosine should be taken additionally within two days after the symptoms disappear, and for chronic recurrent infections, this should be done within two weeks after the exacerbation has stopped. In addition, after stopping the relapse chronic infection You can give Isoprinosine to a child 1 tablet per day for 30 days, and not in full dosage for two weeks.

treatment of influenza and other acute respiratory viral infections;

Infections caused by the Herpes simplex virus types 1, 2, 3 and 4: genital and labial herpes, herpetic keratitis, herpes zoster, chicken pox, infectious mononucleosis caused by the Epstein-Barr virus;

CMV infection;

Severe measles;

Human papillomavirus infection: papillomas of the larynx/vocal cords (fibrous type), human papillomavirus infection of the genitals in men and women, warts;

Molluscum contagiosum.

Release form of the drug Isoprinosine

tablets 500 mg; blister 10, cardboard pack 5;
tablets 500 mg; blister 10, cardboard pack 2;
tablets 500 mg; blister 10, cardboard pack 3;

Compound
Tablets 1 tablet.
inosine pranobex 500 mg
Excipients: mannitol; wheat starch; povidone; magnesium stearate
10 pcs in blister; in a cardboard pack there are 2, 3, 5 blisters.

Pharmacodynamics of the drug Isoprinosine

Isoprinosine is a synthetic complex purine derivative with immunostimulating activity and nonspecific antiviral effect. Restores the functions of lymphocytes in conditions of immunosuppression, increases blastogenesis in the population of monocytic cells, stimulates the expression of membrane receptors on the surface of T-helper cells, prevents a decrease in the activity of lymphocyte cells under the influence of GCS, and normalizes the inclusion of thymidine in them. Isoprinosine has a stimulating effect on the activity of cytotoxic T-lymphocytes and natural killer cells, the functions of T-suppressors and T-helpers, increases the production of immunoglobulin (Ig) G, interferon-gamma, IL-1 and IL-2, reduces the formation of pro-inflammatory cytokines - IL- 4 and IL-10, potentiates the chemotaxis of neutrophils, monocytes and macrophages. The drug exhibits antiviral activity in vivo against Herpes simplex viruses, CMV and measles virus, human T-cell lymphoma virus type III, polioviruses, influenza A and B viruses, ECHO virus (human enterocytopathogenic virus), encephalomyocarditis and equine encephalitis viruses. Mechanism antiviral action Isoprinosine is associated with inhibition of viral RNA and the enzyme dihydropteroate synthetase, which is involved in the replication of some viruses, an increase in the synthesis of lymphocyte mRNA suppressed by viruses, which is accompanied by suppression of the biosynthesis of viral RNA and translation of viral proteins, and an increase in the production of alpha and gamma interferons by lymphocytes, which have antiviral properties. When administered in combination, it enhances the effect of interferon-alpha and antiviral agents (acyclovir and zidovudine).

Pharmacokinetics of the drug Isoprinosine

After oral administration, the drug is well absorbed from the gastrointestinal tract. Cmax of ingredients in blood plasma is determined after 1–2 hours.

It is quickly metabolized and excreted through the kidneys. Metabolized similarly to endogenous purine nucleotides with the formation of uric acid. N-N-dimethylamino-2-propranolone is metabolized to N-oxide, and para-acetamidobenzoate to o-acyl glucuronide. No accumulation of the drug in the body was detected. T1/2 is 3.5 hours for M-M-dimethylamino-2-propranolone and 50 minutes for para-acetamidobenzoate. Elimination of the drug and its metabolites from the body occurs within 24–48 hours.

Use of the drug Isoprinosine during pregnancy

Use of the drug Isoprinosine for impaired renal function

Contraindicated in chronic renal failure, urolithiasis.

After 4 weeks of use, it is advisable to monitor kidney function (creatinine, uric acid levels) every month.

Other special cases when taking Isoprinosine

After 4 weeks of use, it is advisable to monitor liver function (transaminase activity) every month.

Contraindications to the use of the drug Isoprinosine

hypersensitivity to the components of the drug;

Gout;

Urolithiasis disease;

Arrhythmias;

Chronic renal failure;

Children under 3 years of age (body weight up to 15–20 kg).

Side effects of the drug Isoprinosine

Frequency of development side effects after use of the drug is classified according to WHO recommendations. Often - ≥1 and<10%., иногда - ≥0,1 и <1%.

From the gastrointestinal tract: often - nausea, vomiting, epigastric pain, sometimes - diarrhea, constipation.

From the liver and biliary tract: often - a temporary increase in the activity of transaminases and alkaline phosphatase in the blood plasma, an increase in the concentration of urea in the blood plasma.

On the part of the skin and subcutaneous fat: often - itching.

From the nervous system: often - headache, dizziness, weakness; sometimes - drowsiness, insomnia.

From the urinary system: sometimes - polyuria.

From the musculoskeletal system and connective tissue: often - joint pain, exacerbation of gout.

Method of administration and dosage of the drug Isoprinosine

Inside, after meals, with a small amount of water.

The recommended dose for adults and children over 3 years of age (body weight from 15–20 kg) is 50 mg/kg/day, divided into 3–4 doses. Adults - 6–8 tablets/day, children - 1/2 tablet/5 kg body weight/day. In severe forms of infectious diseases, the dose can be increased individually to 100 mg/kg/day, divided into 4–6 doses. The maximum daily dose for adults is 3–4 g/day, for children - 50 mg/kg/day.

Duration of treatment

For acute diseases: the duration of treatment in adults and children is usually from 5 to 14 days. Treatment should be continued until clinical symptoms disappear and for another 2 days in the absence of symptoms. If necessary, the duration of treatment can be increased individually under the supervision of a physician.

For chronic recurrent diseases in adults and children, treatment must be continued in several courses of 5–10 days with a break of 8 days.

For maintenance therapy, the dose can be reduced to 500–1000 mg per day (1–2 tablets) for 30 days.

For herpes infection, adults and children are prescribed for 5–10 days until the symptoms of the disease disappear, during the asymptomatic period - 1 tablet. 2 times a day for 30 days to reduce the number of relapses.

For papillomavirus infection in adults, the drug is prescribed 2 tablets. 3 times a day, for children - 1/2 tablet/5 kg body weight/day in 3–4 doses for 14–28 days as monotherapy.

For recurrent genital warts in adults, the drug is prescribed 2 tablets. 3 times, for children - 1/2 tablet/5 kg body weight/day in 3–4 doses per day, either as monotherapy or in combination with surgical treatment for 14–28 days, then repeating the specified course three times with at intervals of 1 month.

For cervical dysplasia associated with human papillomavirus, 2 tablets are prescribed. 3 times a day for 10 days, then 2-3 similar courses are carried out with an interval of 10-14 days.

Overdose of Isoprinosine

Cases of drug overdose have not been described.

Interactions of the drug Isoprinosine with other drugs

Immunosuppressants may reduce the effectiveness of the drug. Xanthine oxidase inhibitors and uricosurics (including diuretics) may contribute to the risk of increased serum uric acid levels in patients taking Isoprinosine.

Special instructions when taking the drug Isoprinosine

After 2 weeks of use of Isoprinosine, the concentration of uric acid in the blood serum and urine should be monitored.

With long-term use, after 4 weeks of use, it is advisable to monitor liver and kidney functions monthly (transaminase activity in blood plasma, creatinine, uric acid).

Serum uric acid levels should be monitored when isoprinosine is administered in combination with drugs that increase uric acid levels or drugs that impair renal function.

Influence on the ability to drive vehicles and other mechanisms. There are no special contraindications.

Storage conditions for the drug Isoprinosine

On prescription.

Shelf life of the drug Isoprinosine

The drug Isoprinosine belongs to the ATX classification:

J Antimicrobials for systemic use

J05 Antiviral drugs for systemic use

J05A Direct acting antivirals

J05AX Other antivirals

Isoprinosine (table 500 mg N 50) Hungary Biogal

Trade name: Isoprinosine

International name: Inosine Pranobex

Manufacturer: Teva Pharmaceutical Enterprises Ltd [Israel], produced by Pharmaceutical Plant Biogal JSC

Country: Hungary

Packaging 500 mg tablets 10 pcs., contour blister packs (5) - cardboard packs

Registration number P N015167/01

Registration date 10/22/2003

EAN code 5995377281082

pharmachologic effect

Immunostimulating drug with antiviral effect. It is a complex containing inosine and dimethylamino-2-propanol p-acetamido-benzoate in a ratio of 1:3.

The effectiveness of the complex is determined by the presence of inosine; the second component increases its accessibility to lymphocytes. Isoprinosine stimulates biochemical processes in macrophages, increases the production of interleukins, increases the synthesis of antibodies, enhances the proliferation of T-lymphocytes, T-helpers, and natural killer cells. Stimulates the chemotactic and phagocytic activity of monocytes, macrophages and polymorphonuclear cells. Isoprinosine inhibits the replication of DNA and RNA viruses by binding to the cell ribosome and changing its stereochemical structure.

Pharmacokinetics

Suction

After taking the drug orally at a dose of 1.5 g, the Cmax of inosine is achieved after 1 hour and is 600 mcg/ml.

Metabolism and excretion

Inosine is metabolized to form uric acid. T1/2 - 50 min. T1/2 of the second component of the complex is 3-5 hours. Metabolites are excreted by the kidneys.

Indications

Viral infections in patients with normal and weakened immune systems, incl. diseases caused by Herpes simplex virus types 1 and 2, Varicella zoster (including chickenpox), measles, mumps viruses, cytomegalovirus, Epstein-Barr virus; viral bronchitis; acute and chronic viral hepatitis B and C; diseases caused by the human papillomavirus; subacute sclerosing panencephalitis;

Chronic infectious diseases of the urinary and respiratory systems;

Stressful situations;

The period of convalescence in postoperative patients and persons who have suffered serious illnesses;

Immunodeficiency conditions;

Radiation therapy.

Dosage regimen

The daily dose for adults is 50 mg/kg body weight in 3-4 doses; for children - 50-100 mg/kg body weight in 3-4 doses. The duration of treatment is 5-10 days, in severe cases - up to 15 days, long-term use is possible.

For diseases caused by the Herpes simplex virus types 1 and 2, treatment is continued until the symptoms of the disease disappear and for another 2 days.

For subacute sclerosing panencephalitis, the daily dose for adults and children is 50-100 mg/kg body weight in 6 divided doses.

For acute viral encephalitis, the daily dose for adults and children is 100 mg/kg body weight in 4-6 divided doses for 7-10 days. Then follows a break for 8 days, then repeat the course for 7-10 days. If necessary, the dose and duration of the continuous course can be increased, subject to a mandatory break in taking the drug for 8 days.

Long-term treatment is carried out under medical supervision.

Side effect

Metabolism: temporary slight increase in uric acid levels in the blood serum and urine.

Contraindications

Gout;

Urolithiasis disease;

Kidney failure;

Heart rhythm disturbances;

Lactation (breastfeeding);