Klion d tablets. Klion D vaginal tablets: instructions for use and what they are needed for, price, reviews, analogues

Tablets and suppositories for vaginal use are often prescribed to representatives of the fairer sex. Such drugs can be used as prophylaxis and treatment. Some of them are used to eliminate fungal infections. Others are needed to obtain an antibacterial effect. Still others have antiviral activity and immunomodulatory effects. Today’s article will tell you about the combination drug “Klion-D”. Instructions for use will be provided to your attention. You can also read reviews left by consumers about this product and its substitutes. Analogues of "Klion-D" will be described below.

What kind of medicine is this? general characteristics

The drug "Klion-D", the price of which is approximately 400 rubles, is available in the form of suppositories. They are intended for vaginal insertion. The main active ingredients are metronidazole and miconazole nitrate. One tablet contains 100 mg of each substance. The medicine is sold in cardboard packaging. Each pack contains 10 suppositories in individual packaging. The number “100” is written on one side of the tablet. As excipients, the manufacturer uses sodium lauryl sulfate, povidone, colloidal silicon dioxide, magnesium stearate, sodium bicarbonate, lactose monohydrate and some additional components.

Use of the medicine: indications

In what situations is the drug “Klion-D” prescribed? Instructions for use advise using the medicine for bacterial and fungal infections of the female genital tract. The annotation states that the medication is prescribed for the treatment of vaginitis. Doctors recommend medicine when a patient is found to have:

• infections caused by Trichomonas;
• vaginal candidiasis;
• discharge mixed with pus, accompanied by an unpleasant odor.

In addition, suppositories are prescribed for the treatment of sexually acquired diseases (in combination). And also for the purpose of preventing complications after surgical interventions and so on. Before using the medication, it is advisable to undergo an analysis to determine the sensitivity of microorganisms to the active substance.

Limitations and Side Effects

Klion-D suppositories should be used only as prescribed by a doctor. In this case, special attention must be paid to contraindications. They are always written down in the instructions for your reference. The abstract states that it is prohibited to carry out treatment in case of hypersensitivity to the main components and other azoles. This therapy is contraindicated for leukopenia, liver failure, epilepsy and certain lesions of the central nervous system. Tablets are not administered to girls under 12 years of age and to patients who are not sexually active. If such therapy is necessary, it is worth choosing analogues of “Klion-D” in a different form of release.

The side effects that have been officially registered include the following:

1. Negative local reactions: discomfort, itching and burning.
2. Effect on the digestive system. The patient may experience nausea and intestinal upset, and a change in taste.
3. Allergic reactions: itching, urticaria, swelling, redness of the genitals.
4. Headache, exacerbation of existing pathologies.

Some patients indicate that the drug helps change the color of urine. This is normal and goes away on its own after completion of therapy.

Method of use of the combination drug

You already know that the medicine is inserted into the vagina. The dosage of the medication is determined by the doctor. Usually prescribed 1 tablet per day. The course of treatment must be at least 10 days. Before administering the product, wash your hands well. Remove the tablet from the seal and hold it under running water for a few seconds. After this, take a comfortable position and administer the drug. The use of the medication in pregnant women does not imply a reduction in the dose or duration of therapy. The instructions do not recommend using the medicine only in the first trimester. Doctors say that the medication does not have a teratogenic effect on the fetus if doses are observed in the second and third part of pregnancy.

Analogues of "Klion-D"

The drug is replaced by other means if necessary. An alternative medicine is always selected by a doctor. Remember that many products with the same composition have a different dosage. If you have hypersensitivity to components, then you need to use candles based on other substances. Similar medications containing metronidazole include:

• Metromicon Neo.
• "Neo-Penotran".
• "Metromizole".
• "Ginalgin".
• "Clevazole".
• "Pulsitex" and others.

Manufacturers also produce analogues of Klion-D based on other components. Moreover, the drugs have a similar effect on the woman’s genital area. These include:

• "Ginezol".
• "Santequin."
• "Gyno-Travogen".
• "Zalain."
• "Kandibene".
• "Pimafucin".
• "Diflazon".
• "Difluzol".
• "Livarol."
• "McMirror."
• "Clotrimazole" and so on.

Let's look at some drugs in more detail.

"Difluzol" and "Diflazon": instructions for use

The active ingredient of these drugs is fluconazole. This is an antifungal component. The medication “Difluzol” is prescribed for thrush and other fungal diseases of the vagina and mucous membranes. The instructions for use of the drug "Diflazon" allow it to be used for prevention. Doctors recommend carrying out such therapy for recurrent thrush more than three times a year.

The dosage of drugs is selected individually. The instructions indicate that fluconazole is taken in a volume of 0.05 to 0.1 g per day for 2-4 weeks. Both drugs are not prescribed during lactation, but are used during pregnancy. These medications differ from the drug “Klion-D” in that they do not contain an antibiotic.

Use of the drug "Makmiror"

This drug contains two main components: nifuratel and nystatin. The medicine has antifungal, antibacterial and antiprotozoal effects. In this characteristic, it completely coincides with the drug “Klion-D”. Vaginal suppositories "Makmiror" are prescribed for vulvovaginal infections caused by Trichomonas and Candida fungi. The medicine is contraindicated in case of hypersensitivity. In other cases, its use is not limited.

The dosage of the drug is prescribed by a specialist. The daily dose is 1 suppository. The duration of therapy usually does not exceed 8 days. If necessary, the candles can be replaced with one that is sold complete with a convenient applicator.

Suppositories "Ginezol 7"

This drug contains miconazole nitrate. One suppository contains 100 mg of this component. Medicine is prescribed for the treatment of fungal infections of the vagina: candidiasis, balanitis, infections caused by gram-positive microorganisms. The instructions for use indicate late pregnancy, hypersensitivity and renal failure as contraindications to the use of the drug “Ginezol 7” (suppositories). The medication is inserted into the vagina before bed, one suppository at a time. In this case, you must follow all the rules of asepsis. The duration of treatment does not exceed one week.

The drug "Vocadine" and "Betadine": features

These two drugs contain 200 milligrams of povidone-iodine. “Betadine” and “Vocadine” are suppositories that are classified as antiseptics. They are prescribed for treating the vagina after various gynecological procedures (biopsy, puncture, curettage, abortion, and so on). Contraindications to their use include diseases of the thyroid gland and kidneys, breastfeeding, childhood and pregnancy. These analogues do not treat bacterial and fungal infections of the vagina. The drugs are prescribed in a dose of 1 suppository twice a day. The duration of therapy depends on the patient's condition.

Oronazole tablets

The active ingredient in these pills is ketoconazole. The drug belongs to antifungal agents. But he is unable to cope with the bacterial infection. This distinguishes it from the “Klion-D” product, the price of which was stated in the article.

The indication for use of the medication is thrush and other fungal pathologies of the female genital tract. The medication is not used for liver and kidney diseases, during pregnancy and lactation, as well as in young children. Note that Oronazole is available only in the form of tablets for oral administration. You will not be able to purchase candles. The prescription of the medication and the selection of the dose are made by the doctor in accordance with the instructions.

Choice of medicine: reviews

To choose the right drug for treatment, you need to consult a specialist. Doctors say that when prescribing antibiotics, it is imperative to undergo an analysis to determine the sensitivity of microorganisms. This will allow for effective treatment. If a woman’s smear does not reveal a bacterial infection, but only fungal colonies are present, then she needs appropriate therapy. It is almost impossible to choose the right medicine on your own. Experts remind that there is no need to chase the cost of drugs. If a medicine is expensive, this does not guarantee that it will help.

Patients say that they were often prescribed the drug Betadine after various manipulations. The medicine helped carry out antiseptic measures and prevent the development of infection. The drugs "Difluzol" and "Diflazon" are receiving positive reviews due to their effectiveness and safety. These products can be used without fear during pregnancy. It is worth noting that it is during pregnancy that many women first encounter thrush.

The drug "Makmiror" has good reviews due to its action. The medicine is not absorbed into the systemic circulation. It acts exclusively in the vagina. At the same time, the drug has a bactericidal and antifungal effect. Tablets of this trade name are often used to treat intestinal infections.

What do consumers say about the drug "Klion-D"? Women who have used this medication report that it was prescribed to them in conjunction with an oral antibiotic based on metronidazole. This combination is chosen to enhance the effect. It must be remembered that any antibacterial agents are prohibited for use in the first trimester of pregnancy. Therefore, the drug "Klion-D", like other medications with metronidazole, is prescribed only after 16-18 weeks. After completing treatment, you must take a second test. Women say that the advantage of the drug “Klion-D” is its release form. Unlike other fat-based suppositories and vaginal creams, the medication does not leak out and does not stain underwear. The medicine is completely distributed into the vagina.

A little conclusion

The drug "Klion-D" is a popular and effective remedy used for various gynecological infectious diseases. One of its analogues is the drug “Betadine” (suppositories). The price, reviews and method of using the drug "Klion-D" are presented to your review. Please note that not all analogues have the same composition. The original drug has antimicrobial, antibacterial and antifungal effects. Other remedies fight directly against thrush or are classified as antiseptics. And in order to get the correct and qualified prescription, you need to consult a doctor. Be healthy!

Klion D belongs to antiprotozoal drugs that eliminate fungal infections and microorganisms.

Composition and release form of Klion D

In pharmacies, Klion D can be purchased in the form of tablets (20 pieces). 1 tablet of the drug contains 250 mg of metronidazole. Additional ingredients include sodium lauryl sulfate, colloidal anhydrous silica, povidone, magnesium stearate, sodium bicarbonate, tartaric acid, crospovidone and sodium carboxymethyl starch, lactose monohydrate and hydroxypropyl methylcellulose 2910.

They also produce vaginal tablets Klion D 100, 10 pieces per package, which consist of 100 mg of metronidazole and 100 mg of miconazole nitrate. Klion D candles have a white color and a special almond shape, as well as an uneven surface.

In addition, Klion D is produced in the form of an infusion solution (1 bottle of 100 ml).

Pharmacological action of Klion D

The main active ingredient of Klion D tablets and suppositories, metronidazole, restores the 5-nitro group at the biochemical level due to intracellular transport proteins of protozoa and anaerobic microorganisms. A completely reduced 5-nitro group entails the complete disappearance of bacteria.

In addition, the action of Klion D is aimed at destroying fungal cells.

Pharmacokinetics and pharmacodynamics

The instructions for Klion D note that when this drug is used intravaginally, metronidazole is completely absorbed into the blood.

Miconazole is not completely absorbed by tissues. After 8 hours, almost 90% of the miconazole nitrate is still in the vagina. This component of Klion D completely changes and dissolves, without manifesting itself either in the urine or in the blood.

The instructions for Klion D show that metronidazole, which is part of it, has an antiprotozoal effect and also fights various microbes and fungal formations. The drug cannot destroy only facultative anaerobes and aerobic microorganisms.

Miconazole is able to eliminate common dermatophytes, many fungi and yeasts in the body. Also, the instructions for Klion D indicate the antibacterial effect of miconazole against some gram-positive bacteria.

Reviews of Klion D show that this remedy is used to eliminate itching, which often leads to infection. Klion D suppositories are absolutely safe for the female body, because they do not change the pH of the vagina and the specific composition of the microflora.

Indications for use of Klion D

Klion D is prescribed to eliminate infectious and inflammatory diseases, the cause of which is associated with the negative effect of a number of anaerobic bacteria. Such diseases include osteomyelitis, sepsis, brain abscesses, peritonitis, lung and pelvic abscesses, meningitis, endometritis and gas gangrene.

Klion D 100 is also used for preventive purposes to get rid of infectious complications (caused by anaerobic streptococci and bacteroides) after surgery in the abdominal cavity and pelvic organs.

In some cases, Klion D suppositories are used to treat local vaginal infections.

Directions for use and dosage

Klion D tablets are prescribed in the following dosages:

• If the patient has trichomoniasis, take 1 tablet (250 mg) orally, 2 times a day for 10 days. One increased dosage in the evening is also prescribed - 8 tablets (2 g).
• If an adult patient has giardiasis, take 2 tablets orally in the morning and evening for a week.
• For amebiasis in adults - 2 tablets 3 times a day for 1-1.5 weeks.

The instructions for Klion D indicate that this drug is also used in the form of an infusion solution. In this case, children over 12 years of age and adults are administered Klion D by drip, 100 ml every 8 hours. The duration of treatment on average reaches a week. If an urgent need arises, intravenous administration of the drug can be continued. However, it is necessary to ensure that the daily dosage does not exceed 4 g. After completing the course of treatment, the patient is prescribed to take Klion D tablets (400 mg 3 times a day).

For children under 12 years of age, Klion D 100 is administered at the rate of 1.5 ml of solution per 1 kg of body weight (the same dosage remains the same for preventive treatment with this drug).

For prevention, adults and children over 12 years of age are prescribed 100 ml of solution during, before and after surgery. This dosage is repeated every 8 hours. After this, Klion D tablets are prescribed (200-400 mg each).

If the patient has trichomoniasis, she needs to insert 1 Klion D suppository, pre-moistened with water, deep into the vagina. This should be done once before bedtime for 10 days. Additionally, take 1 tablet orally 2 times a day.

Side effects of Klion D

• Reviews of Klion D show that side effects most often include burning, itching and irritation in the vagina (thick, white, odorless discharge), frequent urination, a burning sensation in the partner’s penis;
• Nausea, dry mouth, change in taste preferences, decreased appetite, vomiting, abdominal pain, diarrhea or constipation;
• Reviews of Klion D indicate that rashes, hives, and itching may occur on the skin;
• Dizziness and headache;
• Leukocytosis and leukopenia. In reviews of Klion D, it is noted that quite rarely urine can turn red-brown.

Contraindications for use

Klion D should not be taken in the following cases:

• If the patient is hypersensitive to some components of this drug;
• For blood diseases, leukopenia, problems with coordination of movement, liver failure, disorders of the central nervous system;
• Klion D should not be used during pregnancy (in the first trimester) and lactation;
• Patients with diabetes mellitus and problems with blood microcirculation require additional consultation.

Use during pregnancy and lactation

Klion D is contraindicated during pregnancy in the 1st trimester. In the 2nd and 3rd trimesters, the drug must be prescribed with caution. Use during breastfeeding is not recommended.

Drug interactions of Klion D

Klion D 100 should not be taken together with disulfiram, as the patient may experience mental disorders.

Klion D increases the active substance of indirect anticoagulants, which slows down the formation of prothrombins.

In reviews of Klion D, it is noted that the drug cannot be combined with vecuronium bromide.

Concomitant use of barbiturates reduces the effect of metronidazole.

The use of cimetidine and Klion D 100 increases the concentration of metronidazole in the blood, which leads to the development of side effects.

The use of drugs containing lithium increases their content in the blood plasma.

Precautionary measures

During treatment with Klion D you should abstain from sexual intercourse.

The drug should be used with caution while driving a car or operating complex machinery.

Metronidazole may interfere with the Nelson test.

Storage conditions

Klion D should be stored in a dry place at a temperature of 15-25 degrees.

A drug with antibacterial, antiprotozoal and antifungal effects for topical use in gynecology

Active ingredients

Release form, composition and packaging

Vaginal tablets almost white, oval, biconvex, with a pointed end, with "100" engraved on one side.

Excipients: sodium lauryl sulfate - 0.5 mg, colloidal silicon dioxide - 7 mg, magnesium stearate - 13 mg, povidone - 26 mg, - 90 mg, tartaric acid - 100 mg, sodium carboxymethyl starch (type A) - 100 mg, crospovidone - 100 mg, hypromellose - 190 mg, lactose monohydrate - 473.5 mg.

10 pieces. - aluminum strips (1) - cardboard packs.

pharmachologic effect

A combined drug for intravaginal use containing metronidazole and miconazole.

Metronidazole- antiprotozoal and drug, a derivative of nitro-5-imidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of microbial cells, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria and protozoa.

Active regarding Trichomonas vaginalis, Entamoeba histolytica, Gardnerella vaginalis, Giardia lamblia, as well as obligate anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides ovatus, Bacteroides distasonis, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens) and some gram-positive microorganisms (Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.). The MIC for these strains is 0.125-6.25 μg/ml.

To metronidazole stable aerobic microorganisms and facultative anaerobes, but in the presence of mixed flora (aerobes and anaerobes), metronidazole acts synergistically with antibiotics effective against aerobes.

Miconazole has an antifungal effect against dermatophytes and yeast fungi. When used intravaginally, it is active mainly against Candida albicans. Miconazole inhibits the biosynthesis of ergosterol in fungi and changes the composition of other lipid components in the membrane, which leads to the death of fungal cells. Miconazole does not change the composition of normal microflora and vaginal pH.

Pharmacokinetics

Suction and distribution

When administered intravaginally, metronidazole is absorbed into the systemic circulation. Cmax of metronidazole in the blood is determined after 6-12 hours and is approximately 50% of the Cmax that is achieved (after 1-3 hours) after a single dose of metronidazole orally.

Metronidazole passes into breast milk and most tissues, crosses the blood-brain barrier and the placenta.
Protein binding is less than 20%.

Metabolism and excretion

Metabolized in the liver by hydroxylation, oxidation and glucuronidation. The activity of the main metabolite (2-hydroxymetronidazole) is 30% of the activity of the parent compound.

Excreted by the kidneys - 60-80% of the dose of the systemic drug (20% of this amount unchanged).

The metabolite of metronidazole, 2-hydroxymetronidazole, colors urine red-brown due to the presence of a water-soluble pigment formed as a result of the metabolism of metronidazole. The intestines excrete 6-15% of the dose of the systemic drug.

Systemic absorption of miconazole after intravaginal use is low. Rapidly destroyed in the liver.

It overcomes histohematic barriers poorly. 8 hours after using the drug, 90% of miconazole is still present in the vagina. Unchanged miconazole is not detectable in either plasma or urine.

Indications

— local treatment of vaginitis of mixed etiology caused simultaneously by Trichomonas spp. and Candida spp.

Contraindications

- hypersensitivity to the components of the drug and to other azoles;

— leukopenia (including history);

— organic lesions of the central nervous system (including epilepsy);

- liver failure;

— I trimester of pregnancy;

- lactation period (breastfeeding);

- children under 12 years of age.

Carefully: diabetes mellitus, microcirculation disorders.

Dosage

Intravaginally. 1 vaginal tablet (pre-moistened with water) is inserted deep into the vagina in the evening before bed for 10 days in combination with taking the drug metronidazole orally.

Side effects

Local reactions: itching, burning, pain, irritation of the vaginal mucosa; thick, white, mucous vaginal discharge with little or no odor; burning sensation or irritation of the partner's penis.

From the digestive system: nausea, vomiting, changes in taste, metallic taste in the mouth, decreased appetite, spastic abdominal pain, diarrhea, constipation.

From the side of the central nervous system: headache, dizziness.

From the hematopoietic system: leukopenia or leukocytosis.

Allergic reactions: urticaria, itching of the skin, rash.

From the urinary system: frequent urination, coloring of urine in a red-brown color due to the presence of a water-soluble pigment (metronidazole metabolite - 2 oxymetronidazole), formed as a result of the metabolism of metronidazole.

Overdose

There are no data regarding overdose with intravaginal use of metronidazole. However, when used concomitantly with metronidazole orally, systemic effects may develop.

Symptoms of metronidazole overdose: nausea, vomiting, abdominal pain, diarrhea, generalized itching, metallic taste in the mouth, movement disorders (ataxia), dizziness, paresthesia, convulsions, peripheral neuropathy, leukopenia, dark urine.

Symptoms of miconazole overdose not identified.

Treatment: in case of accidental ingestion of a large number of vaginal tablets Klion-D 100, if necessary, gastric lavage, administration of activated charcoal, and hemodialysis can be performed. Metronidazole does not have a specific antidote. Metronidazole and its metabolites are readily eliminated by hemodialysis.

If any symptoms of overdose occur, symptomatic and supportive therapy is recommended.

Drug interactions

Since the systemic absorption of miconazole is low, interactions with other drugs are caused by metronidazole.

Metronidazole is compatible with sulfonamides and antibiotics.

When consumed simultaneously, alcohol causes reactions similar to disulfiram (cramping abdominal pain, nausea, vomiting, headache, skin flushing). Concomitant use with disulfiram is unacceptable (additive effects, may cause confusion).

The drug is able to enhance the effect of indirect. Prothrombin time may increase, so dose adjustment of indirect anticoagulants is necessary.

Inducers of microsomal oxidation enzymes in the liver (for example, phenytoin) can accelerate the elimination of metronidazole, which leads to a decrease in its concentration in the blood plasma.

Cimetidine inhibits the metabolism of metronidazole, which may lead to an increase in its concentration in the blood serum and an increased risk of side effects.

It is possible to increase the concentration of lithium in the blood plasma during the course of treatment with metronidazole, therefore, before starting to use Klion-D 100, it is necessary to reduce the dose of lithium or stop taking it for the duration of treatment.

special instructions

During the period of use of the drug, alcohol consumption is strictly prohibited (risk of developing disulfiram-like reactions).

When using Klion-D 100, slight leukopenia may be observed, so it is advisable to monitor the blood picture (the number of leukocytes) at the beginning and at the end of therapy.

Metronidazole can immobilize treponemes, resulting in a false-positive TPI test (Nelson test).

Impact on the ability to drive vehicles and machinery

If side effects from the central nervous system occur, you should refrain from driving vehicles and working with potentially dangerous mechanisms.

Pregnancy and lactation

Klion-D 100 is contraindicated for use in the first trimester of pregnancy. The use of the drug in the second and third trimesters is possible only in cases where the potential benefit to the mother outweighs the risk to the fetus.

Metronidazole is excreted in breast milk. During breastfeeding, the use of Klion-D 100 is contraindicated. If it is necessary to use the drug during lactation, breastfeeding should be stopped.

For liver dysfunction

Contraindicated in case of liver failure (when prescribing the drug in high doses).

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

The drug should be stored out of the reach of children, in its original packaging, at a temperature not exceeding 30°C. Shelf life - 5 years.

Tradename:

INN or group name:

Dosage form:

Compound

Description

Pharmacotherapeutic group:

ATX code:

Pharmacological properties

Pharmacokinetics
When administered intravaginally, metronidazole is absorbed into the systemic circulation. The maximum concentration of metronidazole in the blood is determined after 6-12 hours and is approximately 50% of the maximum concentration that is achieved (after 1-3 hours) after a single oral dose of metronidazole. Metronidazole passes into breast milk and most tissues, crosses the blood-brain barrier and the placenta. Communication with plasma proteins is less than 20%. Metabolized in the liver by hydroxylation, oxidation and glucuronidation. The activity of the main metabolite (2-hydroxymetronidazole) is 30% of the activity of the parent compound.
Excreted by the kidneys - 60-80% of the dose of the systemic drug (20% of this amount unchanged). The metabolite of metronidazole, 2-hydroxymetronidazole, colors urine red-brown due to the presence of a water-soluble pigment formed as a result of the metabolism of metronidazole. The intestines excrete 6-15% of the dose of the systemic drug.
Systemic absorption of miconazole after intravaginal use is low.
Rapidly destroyed in the liver. It overcomes histohematic barriers poorly.
8 hours after using the drug, 90% of miconazole is still present in the vagina. Unchanged miconazole is not detectable in either plasma or urine.

Indications for use

Contraindications

• increased individual sensitivity to the components of the drug and other azoles;
• pregnancy (first trimester);
• lactation period;
• leukopenia (including history);
• organic lesions of the central nervous system (including epilepsy);
• liver failure;
• children's age (up to 12 years).

Carefully

Use during pregnancy and lactation

Directions for use and doses

Side effect

Overdose

Interaction with other drugs

special instructions

Impact on the ability to drive a car and other mechanical means.
If side effects from the central nervous system occur, you should refrain from driving vehicles and working with potentially dangerous mechanisms.

Release form

Storage conditions

Klion-D 100 is an antiviral, antifungal drug for external use.

The main feature is the combinatorial chemical interaction of two active substances - metronidazole and miconazole. It is a completely synthetic drug that treats diseases associated with infections of the genital system.

On this page you will find all the information about Klion D: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews from people who have already used Klion D suppositories. Do you want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

A drug with antibacterial, antiprotozoal and antifungal effects for topical use in gynecology.

Conditions for dispensing from pharmacies

Dispensed with a doctor's prescription.

Prices

How much do Klion D candles cost? The average price in pharmacies is 400 rubles.

Release form and composition

• Active ingredients: 100 mg metronidazole and 100 mg miconazole nitrate in each vaginal tablet.
• Excipients: sodium lauryl sulfate; colloidal silica anhydrous; magnesium stearate; povidone; sodium bicarbonate; wine acid; sodium carboxymethyl starch type A; crospovidone; hypromellose; lactose monohydrate.

Pharmacological effect

The antifungal effect that the drug Klion-D has is possible due to the content of two powerful components - miconazole and metronidazole.

The first active substance of vaginal tablets fights the fungus itself, by affecting the cell membrane of microorganisms. They begin to weaken and soon die. Miconazole relieves the irritating itching that accompanies all fungal ailments. This component of the drug is poorly absorbed into the blood if introduced into the vagina. Its presence is not detected either in the blood or in waste products. The advantage of miconazole is that even after 8 hours, about 90% of the substance is in the vaginal environment, providing an antifungal effect all this time.

Metronidazole Klion-D 100 acts as an antibacterial and antiprotozoal agent. It penetrates the DNA of microbes and blocks the process of cell division. With the help of this substance, the pathogen stops growth and reproduction.

Indications for use

What do they treat? Klion D is prescribed to eliminate infectious and inflammatory diseases, the cause of which is associated with the negative effect of a number of anaerobic bacteria. Such diseases include osteomyelitis, sepsis, brain abscesses, peritonitis, lung and pelvic abscesses, meningitis, endometritis and gas gangrene.

• It is also used for preventive purposes to get rid of infectious complications (caused by anaerobic streptococci and bacteroides) after surgery in the abdominal cavity and pelvic organs.

In some cases, suppositories are used to treat local vaginal infections.

Contraindications

Klion D should not be taken in the following cases:

1. Klion D should not be used during pregnancy (in the first trimester) and lactation;
2. For blood diseases, leukopenia, problems with coordination of movement, liver failure, disorders of the central nervous system;
3. Patients with diabetes mellitus and blood microcirculation disorders require additional consultation;
4. If the patient is hypersensitive to some components of this drug.

Use during pregnancy and lactation

Klion-D 100 is contraindicated for use in the first trimester of pregnancy. The use of the drug in the second and third trimesters is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

Metronidazole is excreted in breast milk. During breastfeeding, the use of Klion-D 100 is contraindicated. If it is necessary to use the drug during lactation, breastfeeding should be stopped.

Instructions for use

The instructions for use indicate that Klion-D suppositories are used intravaginally, after moistening the tablet with water.

Typically, the course of treatment with Klion-d 100 lasts 10 days with simultaneous oral administration of drugs containing metronidazole (Klion-d).

Instructions for tablets

Klion-d in tablet form is taken:

1. For giardiasis - 2 tablets 2 times a day for a week;
2. For amoebiasis - 2 tablets three times a day for 7-10 days;
3. For trichomonas - one twice a day, morning and evening, for 10 days. It is possible to use 8 tablets as a single dose in the evening.

Side effects

The drug is well tolerated by patients, but in some cases the following adverse reactions develop:

1. Change in urine color;
2. Increased vaginal discharge;
3. Changes in the clinical blood picture;
4. From the central nervous system – dizziness and headaches;
5. Allergic reactions - skin rash, urticaria, in rare cases, the development of angioedema;
6. From the digestive tract - in rare cases, stool disturbances, changes in taste, dry mouth, nausea, abdominal pain, increased gas formation;
7. Local manifestations - discomfort, itching, burning, swelling, redness of the mucous membranes, sensation of a foreign body in the vagina.

Overdose

There are no data regarding overdose with intravaginal use of metronidazole. However, when used concomitantly with metronidazole orally, systemic effects may develop.

Symptoms of metronidazole overdose: nausea, vomiting, abdominal pain, diarrhea, generalized itching, metallic taste in the mouth, movement disorders (ataxia), dizziness, paresthesia, convulsions, peripheral neuropathy, leukopenia, dark urine.

Treatment: in case of accidental ingestion of a large number of vaginal tablets Klion-D 100, if necessary, gastric lavage, administration of activated charcoal, and hemodialysis can be performed. Metronidazole does not have a specific antidote.

No symptoms of miconazole overdose have been identified.

special instructions

1. Metronidazole can immobilize treponemes, resulting in a false-positive TPI test (Nelson test).
2. During the period of use of the drug, you should not drink alcohol (risk of developing disulfiram-like reactions).
3. When using Klion-D 100, slight leukopenia may be observed, so it is advisable to monitor the blood picture (the number of leukocytes) at the beginning and at the end of therapy.
4. During the period of use of the drug, it is recommended to abstain from sexual intercourse. Simultaneous treatment of sexual partners is recommended.

If side effects from the central nervous system occur, you should refrain from driving vehicles and working with potentially dangerous mechanisms.

Drug interactions

Klion-D 100 may cause negative reactions with other medications, or, on the contrary, increase effectiveness. Do not combine the drug with the following compounds:

1. Phenobarbital leads to a decrease in metronidazole concentrations.
2. Cimetidine can cause toxicity as it impairs metabolism.
3. Muscle relaxants of the non-depolarizing category.
4. Absolute antagonism with ethanol.
5. The content of lithium components increases, which requires adjustment of the dosage of such medications.

The drug is compatible with antibiotics of different groups, including para-aminobenzenesulfamides. You should refrain from intimacy during the course.