In what cases and how to take dicynone during menstruation. What do Dicinon tablets help with?

Many female representatives suffering from intense or often look for ways to stabilize this physiological process. One of the most common drugs that can cope with such unpleasant manifestations is Dicinon during menstruation.

Before using such a drug, you should fully study its composition, learn about existing contraindications and possible side effects. However, even after a full study of Dicinon, it should be remembered that this pharmacological agent is allowed to be used only after a series of diagnostic tests and only as prescribed by the attending physician.

More about the drug

Dicynon is a hemostatic (hemostatic) drug that has many beneficial effects, relative to existing analogues. The main active ingredient is etamsylate, which strengthens the vascular walls, stabilizes blood circulation and improves the process of blood clotting.

The advantages of a pharmacological preparation are as follows:

  • Dicinon does not affect the composition of the blood flow;
  • Does not cause any harm to the blood supply system;
  • It provokes the formation of platelets only in the right places, improves and prolongs their performance.

Due to the above useful properties Dicinone, it is often used in the medical industry for periodic uterine bleeding, prolonged or excessive heavy menstruation, under threat spontaneous interruption pregnancy and after abortion.

Assign this remedy an exclusively qualified doctor should, based on the results of the tests and the individual characteristics of the female body.

How does it affect the body

Release form

In the pharmacological industry, Dicinon is available in two forms:

  1. Tablets. In addition to the main active element (etamsylate) in medicinal dragees lactose is also added. Positive effect observed approximately 3-4 hours after the use of the drug and lasts for 7-9 hours. It is recommended to use Dicinon in tablets for not very abundant, but periodic uterine hemorrhages that do not require an immediate result;
  2. Ampoules. The injection is made into a vein or into a muscle. The effect of the drug is observed almost instantly (no more than 20 minutes after use) and lasts about 6-7 hours. The use of this form of release is necessary when heavy bleeding, the provocateurs of which are the progression of diseases such as fibromyoma, endometriosis, endometritis or other pathologies caused by a serious hormonal imbalance.

form pharmacological agent, which is necessary in your case, must choose qualified specialist who is aware of existing problems and individual characteristics your body.

Is it possible to use for delay

Sometimes girls have a desire. Such a desire, as a rule, appears if she is going on vacation, to the beach or nature with friends. In such situations, many people have the question of the possibility of using Dicinon to delay menstruation.

The answer to this question is positive. Medical experts are confident that the use of the drug can delay the onset of menstruation by about 1.5-2 weeks. For a delay, you should take a pharmacological agent three times a day 4 days before the expected critical days.

However, it should be remembered that such a manipulation of the self-regulation of menstruation is allowed to be performed no more than once every 12 months, otherwise you can provoke a lot of adverse consequences and significantly disrupt the level hormonal background, which, as a result, will lead to the emergence of dangerous diseases.

Indications for use

The drug Dicinon has the following indications for use:

  • Excessively, whose provocateurs are gynecological pathologies(leiomyoma, endometriosis, dysplasia, hyperplasia, etc.);
  • Intensive bloody issues arising between natural critical days;
  • With a high probability of spontaneous abortion (miscarriage);
  • Preparatory procedures before the subsequent surgical intervention;
  • Intense bleeding, the provocateurs of which are pharmacological preparations mandatory for use;
  • Excessively heavy periods, which are caused by an unstable process of blood flow clotting;
  • Long critical days.

Dicinon is also prescribed in other cases, but this is possible only under the clear guidance of a qualified medical worker.

Contraindications

Beyond all positive properties medicinal substance there are also situations in which it is strictly forbidden to drink Dicinon:

  • Individual intolerance to the body of the components that make up the drug;
  • Oncological diseases of the circulatory system;
  • Progression of acute porphyria;
  • Increased blood viscosity;
  • Diseases affecting the cardiovascular system;
  • The period of breastfeeding;
  • The presence of thrombosis and thromboembolism.

Before you start using this pharmacological agent, you must carefully study the instructions, familiarize yourself with existing contraindications and consult with your doctor.

Side effects

After using Dicinon, the following side effects are possible:

  • Attacks of nausea and vomiting;
  • Feeling of discomfort in the peritoneum;
  • The appearance of heartburn;
  • Sharp, unconditional jumps blood pressure;
  • Various manifestations of an allergic reaction (rash, itching, redness of the skin);
  • Headaches and dizziness;
  • Numbness of the lower and upper limbs;
  • Aversion to certain kinds of smells.

Typically, the above side effects are the norm, disappear quickly and do not require treatment medical professionals. But if the adverse symptoms do not disappear and continue to disturb you for a long time, then you should contact the nearest medical institution for proper help.

How to take Dicinon

Instructions for use of Dicinon tablets should be fully studied in without fail before you start taking. Particular attention should be paid to the fact that various pathologies in women's reproductive system, the methods of application are different from each other:

  • Preventive measures for excessively heavy periods. In this case, the drug should be used on the third day after the start of the critical days. A single dose is 250 mg. medicines 3 times a day. At correct use Dicinon, in the following days, the discharge will become less intense, the condition of the female representative will improve, drowsiness, weakness and unnatural fatigue will disappear;
  • Prolonged menstruation. If the bleeding does not stop within a week, then it is necessary to start using this pharmacological agent at 250 mg. once a day until the end of the critical days. It is forbidden to use Dicinon, in this case, for more than 10 days, as this can provoke the occurrence of irreversible, pathological processes in the body. AT similar situations the task of the doctor is to reduce the prescribed dosage and conduct the necessary diagnostic studies that will help identify the cause of excessively long menstruation;
  • Dicynon for heavy menstruation. In this case, as a rule, the admission scheme is drawn up individually. Most often, the drug is used on the fifth day after the start, using 250 mg each. medicines 3 times a day for 10 days. Thanks to taking the drug, the walls of the vessels will become more durable and elastic, which will not allow them to be so excessively damaged during the next critical days;
  • During childbearing. In situations where bleeding occurs during pregnancy, it is recommended to take one tablet of Dicinon. If its use has not brought any results, visit a gynecologist immediately to prevent miscarriage or other complications of an ongoing pregnancy.

Despite the described scheme of reception medicinal product, qualified physicians strongly recommend discussing the possibility of using the drug with your doctor.

Solution use

The use of dicynone during menstruation and in other possible cases in the form of a solution is prescribed only in emergency situations, when the effect is needed immediately (within 10-20 minutes). The injection can be made intravenously or intramuscularly at a dosage of one to two ampoules 3 times a day.

As a rule, it is most often necessary to use the drug in this form at the time of surgery. With his help medical workers easily prevent possible hemorrhages. The dosage in such cases is as follows:

  • Two ampoules before surgery;
  • Two injections at the time of the operation;
  • Two ampoules after the completion of the treatment procedure.

In other cases, the dosage of the drug is prescribed exclusively by the attending doctor.

Analogues

Similar healing effect provide the following drugs containing etamsylate:

  • Impedil;
  • Aglumin;
  • Etamzilat-Ferein;
  • Altodor;
  • Cyclonamine.

Price

Dicynon can have a varied cost, which depends on the country, region and locality. As a rule, the price varies from 40 to 150 rubles for a pack of 10 tablets, and from 350 to 450 rubles for a pack of 100 dragees. 50 ampoules for intramuscular or intravenous injections cost from 550 rubles.

The drug is released without a prescription.

Self-medication can be harmful to your health.

Dicinon tablets: instructions for use

Compound

Each tablet contains 250 mg of etamsylate.

Excipients: lemon acid anhydrous (E330), corn starch, lactose monohydrate, povidone, magnesium stearate.

Description

White or almost white, round, biconvex tablets.

pharmachologic effect

Dicynon is a hemostatic agent. Its hemostatic effect is based on accelerating the first phase of hemostasis - stimulating the interaction between the endothelium and platelets. Dicynon protects the endothelium, increases platelet adhesion to damaged vascular walls, especially capillaries, reduces the permeability of capillary walls, inhibits the biosynthesis of prostaglandins, which cause disaggregation and vasodilation and, consequently, increase capillary permeability. Due to the action of the drug, bleeding time is significantly shortened and blood loss is reduced.

Dicynon does not have vasoconstrictive properties. It has no effect on fibrinolysis or normal mechanism blood clotting, so it does not have a thrombogenic effect. Dicinone inhibits the actions of both hyaluronidase and histamine, thereby reducing the increased capillary permeability when various diseases such as inflammation. Dicynon significantly reduces the incidence of intraventricular bleeding in the brain in low birth weight infants. The frequency of cerebral hemorrhage in children whose mothers received the drug was significantly lower compared to children whose mothers did not receive this drug.


Pharmacokinetics

When taken orally, etamsylate is rapidly absorbed from gastrointestinal tract. After oral administration of 50 mg of etamsylate, the maximum plasma level (about 15 μg / ml) was reached after 4 hours. The plasma half-life is 3.7 hours. About 72% of the dose taken is excreted in the urine during the first 24 hours.

Etamzilat gets through a placental barrier and into breast milk.

Indications for use

Prevention and control of bleeding during and after surgical operations in otolaryngology, gynecology, obstetrics, urology, dentistry, ophthalmology and plastic surgery

Prevention and control of capillary bleeding various etiologies and localization: hematuria, metrorrhagia, primary menorrhagia, menorrhagia in women using intrauterine contraceptives, nose bleed, bleeding gums

Contraindications

Hypersensitivity to the active substance of the drug - etamsylate or to any of the excipients

Hypersensitivity to sodium sulfite in anamnesis

Hemoblastosis in children (lymphatic and myeloid leukemia, osteosarcoma)

Acute porphyria

Thrombosis, thromboembolism

Lactation

Pregnancy and lactation

The effect of etamsylate on pregnant women is unknown. Etamzilat passes through the placental barrier, so its use is contraindicated in the first trimester of pregnancy. Clinical Application during pregnancy is not significant for these indications.

Etamsylat passes into breast milk. You should not breast-feed while taking this medicine.

Dosage and administration

Use in adults and children over 14 years of age

Before surgery: one two tablets of Dicinon 250 mg (250-500 mg) within one hour before surgery.

After surgery: one to two tablets of Dicinone 250 mg (250-500 mg) every 4-6 hours as long as there is a risk of bleeding.

Internal illnesses: general recommendations Take two 250 mg tablets two Dicinone three times a day (1000-1500 mg) with meals with a little water. Gynecology, for meno-/metrorrhagia: take two Dicinon 250 mg tablets three times a day (1.500 mg) with meals with a little water. The treatment lasts 10 days, starting five days before the onset of bleeding.

In pediatrics (children over 6 years old)

Daily dose is 10-15 mg / kg of body weight per day, divided into 3-4 doses. The duration of the drug depends on the massiveness of blood loss and ranges from 3 to 14 days from the moment the bleeding stops in all categories of patients.

The tablets should be taken with or after a meal. Special groups population

There are no studies in patients with impaired liver or kidney function. Thus, Dicinon should be used with caution in these groups of patients.

Skipping a dose

Do not take a double dose to make up for a missed one.

Side effect

Possible unwanted effects: headache, dizziness, flushing of the face, transient skin disorders, nausea, pain in the epigastric region, paresthesia of the legs. These reactions are transient and not severe.

There is evidence that in children with acute lymphocytic and myeloid leukemia, osteosarcoma, etamsylate, prescribed for the prevention of bleeding, caused severe leukopenia. According to a number of literature data, the use of etamsylate in children is contraindicated.

There is evidence that in women who took etamsylate before surgery, thrombosis was noted on the cervix after surgery. However, recent tests have not confirmed these data.

Overdose

Interaction with other drugs

Application features

This medicinal product should be used with caution in patients with a history of thrombosis or thromboembolism or hypersensitivity to medicines. Dicynon contains sulfites, which is why it is also necessary to be careful when administering it to patients with bronchial asthma and allergies. Before starting treatment, it must be borne in mind that the drug is ineffective in patients with thrombocytopenia.

Due to the fact that in children who were prescribed Dicinon for the prevention of bleeding in acute lymphoblastic and myeloid leukemia and osteosarcoma, there was an aggravation of the condition, some authors consider the use of the drug in these cases contraindicated.

The drug should not be prescribed to patients with such rare hereditary diseases such as lactase deficiency or malabsorption of glucose-galactose.

Etamzilat does not affect the ability to manage vehicles and work with mechanisms.

If you are intolerant to carbohydrates, consult your doctor before taking the drug.

Precautionary measures

Release form

10 tablets in aluminium/PVC/PVDC blister.

It is necessary to consult a doctor, and also read the instructions before use.

The drug Dicinon is an ambulance that is used to stop bleeding of various origins.

Release form and composition

Dicinon is available in tablets and in the form of a solution for injection.

The active substance of the drug is etamsylate. Its concentration in one tablet is 250 mg, in 1 ml of solution - 125 mg.

As auxiliary components, Dicinon tablets include anhydrous citric acid, corn starch, magnesium stearate, povidone K25, lactose.

In addition to etamsylate, the solution contains sodium disulfite, water for injection, sodium bicarbonate (in some cases it is necessary to correct the pH level).

Tablets are delivered to pharmacies packaged in 10 pieces in blisters, sold in 10 blisters in a carton. The solution for intramuscular and intravenous administration is sold in 2 ml colorless glass ampoules, 10 ampoules in a blister, 5 blisters in a cardboard box.

Indications for use

The use of Dicinon is indicated for the treatment and prevention of capillary bleeding of various origins.

According to the instructions, etamsylate is effective for:

  • Bleeding during and after surgical interventions on all well-vascularized (permeated blood vessels) tissues in obstetrics and gynecology, ENT practice, dentistry, plastic surgery, urology, ophthalmology;
  • Menorrhagia, including primary, as well as in women with an intrauterine contraceptive;
  • bleeding gums;
  • Hematuria;
  • nosebleeds;
  • metrorrhagia;
  • Diabetic microangiopathy, including hemophthalmos, hemorrhagic diabetic retinopathy etc.;
  • Hemorrhagic disorders cerebral circulation in newborns, including premature babies.

Contraindications

In accordance with the instructions for Dicinon, the use of the drug is contraindicated if the patient has:

  • Neoplastic (tumor) diseases of the lymphatic and hematopoietic tissues, including osteosarcoma, myeloid and lymphoblastic leukemia;
  • Thrombosis;
  • Acute porphyria;
  • Thromboembolism;
  • Hypersensitivity to the components of the tablets / solution.

With caution, Dicinon is used to treat patients with a history of thrombosis or thromboembolism, as well as in cases where the cause of bleeding is an overdose of anticoagulants.

Method of application and dosage

The optimal daily dose of Dicinon in tablet form for an adult is from 10 to 20 mg per 1 kg of body weight. Divide it into 3 or 4 doses.

As a rule, the average single dosage is 250-500 mg, in exceptional cases it is increased to 750 mg. The frequency of applications of Dicinon is the same, 3-4 times a day.

With menorrhagia, the daily dose of etamsylate is from 750 mg to 1 g. Dicinon is taken from the 5th day of the expected menstruation and until the 5th day of the next cycle.

After surgical interventions, the drug is recommended to be taken every 6 hours at 250-500 mg. Continue taking the tablets as long as there is a risk of bleeding.

For a child single dose is 10-15 mg per 1 kg of body weight. Multiplicity of applications - 3-4 times a day.

The instructions for Dicinon indicate that the injection solution is intended for slow intravenous or intramuscular injections. In cases where the agent is diluted with saline, the injection should be done immediately.

For an adult, the daily dose is 10-20 mg / kg / day, it should be divided into 3-4 injections.

AT preventive purposes at surgical interventions Dicynon is administered intravenously or intramuscularly at a dose of 250-500 mg approximately one hour before surgery. During a surgical operation, the drug is administered intravenously in a similar dose, if necessary, the administration of this dose is repeated again. In the postoperative period, it is recommended to use Dicinon at the initial dosage every 6 hours until the risk of bleeding disappears.

For children, the solution is prescribed at a dose of 10-15 mg / kg / day, divided into 3-4 injections. In neonatological practice, Dicinon is injected into a muscle or very slowly into a vein at a dose of 12.5 mg / kg (the indicated dose of etamsylate corresponds to 0.1 ml of solution). Treatment begins in the first two hours of a child's life.

Side effects

The use of Dicinon may be accompanied by headaches, paresthesia lower extremities, dizziness, heartburn, nausea, a feeling of heaviness in the epigastric region, flushing of the skin of the face, allergic reactions, a decrease in systolic pressure.

special instructions

Dicinon injection solution is intended exclusively for use in clinics and hospitals.

It is forbidden to mix the solution in one syringe with any other drug. It is contraindicated to use the solution if it has changed color.

It should be borne in mind that Dicinone at a dose of 10 mg / kg, administered one hour before dextrans, prevents their antiplatelet effect. And Dicinon, introduced after dextrans, does not have a hemostatic effect.

Dicynone is incompatible with sodium lactate and sodium bicarbonate injections. If necessary, it can be combined with menadione sodium bisulfite and aminocaproic acid.

One Dicinon tablet contains 60.5 mg of lactose (the permissible highest dose of this substance is 5 grams). Tablets are contraindicated in patients with lactase deficiency, congenital intolerance glucose, malabsorption of glucose and galactose. Rating: 4.6 - 63 votes

Any woman will be greatly frightened by spotting from the genital tract, not associated with menstruation. Having received a “dose of stress”, the fair sex run to their gynecologist for help and finding out the reasons for the appearance of such an incomprehensible symptom.

Very often, with such bleeding, doctors prescribe hemostatic drugs. One of the most "universal" and "popular" is Dicinon.

Description of the drug Dicinon

Uterine bleeding is a dangerous symptom that requires immediate medical attention.

Uterine bleeding is all bleeding from the uterus that is not associated with menstruation (they are called acyclic). Also, uterine bleeding can be considered a sharp increase in the number blood secretions during menstruation (this is accompanied by the release of blood clots) and their duration.

The reasons for this dangerous symptom can be varied:

  • uterine fibroids;
  • endometriosis;
  • adenomyosis;
  • hemosalpinx;
  • benign formations of the uterus and appendages;
  • malignant neoplasms of the uterus and appendages;
  • complications of pregnancy and childbirth;
  • blood clotting disorders, including DIC - syndrome;
  • progressive thrombocytopenia;
  • hormonal disorders;
  • taking medications and others.

Dicynon - first aid for uterine bleeding

Dicynon is a hemostatic drug (hemostatic), which is most often used to stop bleeding, is widely used not only in gynecology, but also in other areas of medicine. It prevents fragility of capillaries, reduces their permeability, improves blood flow in them, coagulates blood in places of vascular damage (this happens due to sharp decline working out biologically active substances prostaglandins, which prevent platelets from sticking together bloodstream) without causing thrombosis.

The action of the drug in intravenous administration noted after ten to fifteen minutes, with intramuscular injection - after half an hour, when taking a tablet form - after an hour and a half.

In addition to uterine bleeding, it will be necessary for:

  • treatment of bleeding after surgical interventions;
  • treatment of bleeding of various etiologies;
  • treatment of microangiopathies in diabetes mellitus.

Forms of release and composition

Dicynon can be found in two forms:

Dicynon in the form of an injection solution

Dicynon in the form of tablets

The active component of Dicinon is the substance etamsylate.

Auxiliary components for each form are different:

  • for tablets:
    • lactose;
    • corn starch;
    • magnesium stearate;
    • povidone;
    • anhydrous citric acid;
  • for infusion solution:
    • purified water for injection;
    • sodium metabisulfite;
    • sodium bicarbonate.

The tablet form is available in blisters (blister packs) of 10 tablets. Packed in a cardboard box with annotation to the drug. The box contains 10 blisters (100 tablets). Some pharmacy chains they do not sell the entire package, but release blisters individually. biconvex tablets, round shape, white.

The injection form is produced in two-milliliter ampoules, which are packed in cardboard boxes in the amount of 10 or 50 pieces with an annotation to the drug. The solution is colorless clear liquid no visible inclusions.

Possible side effects when taking

Like all medicines, Dicinon has a number of contraindications and may cause some side effects.

Possible side effects

When using Dicinon, you may experience:

  • redness of the skin;
  • lowering blood pressure (mainly systolic);
  • dizziness;
  • headache;
  • abdominal pain (mainly in the epigastric region);
  • nausea up to the development of vomiting;
  • paresthesia.

If you believe the instructions for the drug, all these phenomena are considered temporary and completely disappear after the drug is discontinued.

Contraindications for use

Not everyone can use this drug. You should look for a replacement for Dicinon if there are:

  • thrombosis;
  • thromboembolism;
  • hemoblastosis;
  • violations of porphyrin metabolism;
  • liver failure;
  • kidney failure;
  • sensitivity to etamsylate;
  • individual components of the drug.

Dicinon does not enhance or block the effect of other drugs. But it should be remembered that the injection solution must not be mixed with solutions of sodium bicarbonate and sodium lactate, as they are incompatible.

The use of the drug during pregnancy, lactation, menopause

The use of Dicinon during pregnancy is not prohibited. But the reception should be carried out extremely carefully and under the strict supervision of a specialist. Due to the insufficient amount of information about the effect on the fetus, the drug is best used in tablet form. So the active substance, in contrast to parenteral administration, gradually spreads throughout the body in a lower concentration.

During lactation, Dicinon is also allowed. But for the duration of treatment and at least five days after its completion, you should stop breast-feeding and temporarily transfer the child to food artificial mixture, since the drug can be released from breast milk and adversely affect the health of the baby.

Use during menopause is allowed. Moreover, Dicinon is the drug of choice for gynecologists in the fight against uterine bleeding during the menopause.

Instructions for use during uterine bleeding

The dosage of the drug is selected for each patient individually. It depends on the type of bleeding, its cause, amount lost blood and others.

Dicinon is a rather serious drug, which, without finding out the causes of bleeding, should never be taken on its own. Only a qualified specialist can appoint it.

Usually, the drug, both in the form of tablets and in the form of an injection solution, is prescribed to be taken three to four times a day and not more than five days. Usually this period of time is enough to eliminate blood loss. After this period, if the blood has not been properly stopped, the question is raised of increasing the dosage of the drug and continuing to use it for a few more days, or replacing Dicinon with another, more effective drug.

With heavy menstruation, the drug should be taken from the fourth to fifth day menstrual cycle until the bleeding stops completely. The dosage can be determined at the appointment with the gynecologist. He will evaluate the "all scale" of blood loss, general state body and prescribe an individual daily dose.

What can replace

Dicinon has analogues, both structural and with another active substance, which have the same hemostatic effect.

What can replace Dicinon - table

Name of the drug Release form Active substance Indications Contraindications average price
Vikasol
  • tablets;
  • infusion solution
menadione sodium bisulfite
  • unspecified hemorrhagic conditions;
  • insufficiency of a blood coagulation factor;
  • heavy menstruation;
  • dysfunctional uterine bleeding;
  • vitamin K deficiency
  • hemolytic disease;
  • thromboembolism;
  • increased blood clotting;
  • individual intolerance
50 rubles
Aminocaproic acid infusion solution aminocaproic acid
  • bleeding;
  • hemorrhagic syndrome;
  • placental abruption;
  • massive blood transfusions;
  • hypoplastic anemia;
  • burn disease;
  • shock states
  • pregnancy;
  • lactation period;
  • acute disorders of cerebral circulation;
  • thrombosis;
  • thromboembolism;
  • kidney failure;
  • individual intolerance
70 rubles
Tranexam
  • tablets;
  • infusion solution
tranexamic acid
  • bleeding;
  • bleeding during pregnancy;
  • inflammatory diseases;
  • allergic diseases, including angioedema;
  • shock states
  • thrombosis;
  • thromboembolism;
  • disorders of cerebral circulation;
  • individual intolerance
from 200 rubles
Etamzilat infusion solution etamsylate
  • bleeding;
  • bleeding during pregnancy;
  • shock conditions;
  • postoperative bleeding;
  • heavy menstruation
  • thrombosis;
  • thromboembolism;
  • individual intolerance
40 rubles

Dicinon 250 is a drug that has a hemostatic effect. It is used to treat diseases accompanied by a violation of blood clotting. Has contraindications and side effects Therefore, it should be used in the doses prescribed by the doctor.

Etamzilat

ATX

Forms of release and composition

The drug may look like:

  1. Tablets are round, biconvex, white or beige. Each contains 250 mg of etamsylate, milk sugar, dehydrated citric acid, povidone, magnesium stearate, potato starch. Tablets are packaged in blisters of 10 pcs. AT cardboard box includes 1 contour cell.
  2. Solution for injection, which can be administered intramuscularly or intravenously. It is a colorless transparent liquid, which is poured into 2 ml ampoules. The composition of 1 ampoule includes 250 mg of etamsylate, sodium disulfite, water for injection, sodium bicarbonate. Ampoules are packed into plastic cells on 10 pieces. Cardboard pack includes 5 blisters.

pharmachologic effect

The active substance has the following properties:

  • increases the amount of mucopolysaccharides with a large molecular weight produced by the walls of the capillaries;
  • increases the resistance of capillaries, reduces the permeability of the vascular walls;
  • restores blood circulation in small vessels;
  • stops bleeding by increasing the activity of thromboplastin at the sites of capillary damage;
  • promotes the production of a blood coagulation factor, increases platelet adhesion;
  • does not reduce prothrombin time, does not lead to a pathological increase in blood clotting;
  • does not contribute to thrombosis.

Pharmacokinetics

At parenteral administration maximum dose the drug (50 mcg / ml) is determined after 10 minutes. When using tablet forms of the drug, etamzilat is quickly and completely absorbed by the intestinal walls. Therapeutic Concentration active ingredient in the blood is reached after 4 hours. 70% of the administered dose is excreted in the urine during the first day.

Indications for use

The drug is used for the treatment and prevention of:

  • bleeding that occurs when surgical operations on tissues characterized by increased blood supply;
  • postpartum bleeding;
  • cystitis, accompanied by the appearance of blood in the urine;
  • primary menorrhagia;
  • bleeding gums;
  • nosebleeds;
  • bleeding that occurs after the installation of intrauterine contraceptives;
  • diabetic microangiopathy (hemorrhagic retinopathy, accompanied by retinal hemorrhage);
  • hemorrhagic syndrome in newborns and premature babies.

Contraindications

The drug is contraindicated in the following conditions:

  • exacerbation of porphyria;
  • lymphoblastic and myeloid leukemia, malignant tumors bones;
  • thrombosis and thrombophlebitis;
  • thromboembolism;
  • individual intolerance to active substances and auxiliary components;
  • bleeding caused by an overdose of anticoagulants;
  • Werlhof-Willebrand disease.

How to take Dicynon 250

The method of administration and doses depend on the form of release of the drug:

  1. Tablets. The recommended single dose for adults is 250-500 mg. Tablets are drunk 3-4 times a day. In severe bleeding, the daily dose is increased to 3 g. With heavy menstruation, treatment begins with 750-1000 mg per day 5 days before the expected menstruation. They are treated until the 5th day of the new menstrual cycle. After surgery, take 1-2 tablets every 6 hours to reduce the risk of bleeding. The daily dose for children is 10 mg/kg.
  2. Injection. Adults are administered 10-20 mg / kg per day intravenously or intramuscularly slowly. During operations, 250-500 mg of etamsylate is administered one hour before the procedure. During the intervention, the injection is repeated. In the early postoperative period administered 4 times a day at a dose of 250 mg. Daily dose at hemorrhagic syndrome in newborns - 12.5 mg / kg. Treatment begins in the first hours after birth.

How many days to take

The course of treatment should not last more than 10 days.

Taking medication for diabetes

In diabetic vascular lesions, the drug is administered intravenously in an amount of 250 mg per day. The dose is divided into 2 injections.

Side effects of Dicinon 250

Against the background of taking a hemostatic drug, the following negative consequences may occur:

  • neurological disorders (headaches, decreased sensitivity of the lower extremities, dizziness);
  • digestive disorders (attacks of nausea and vomiting, heaviness in the stomach, loose stools);
  • other side effects (reddening of the skin of the face, lowering of upper arterial pressure, allergic reactions in the form of a rash skin itching and hives)

Influence on the ability to control mechanisms

The drug may cause side effects that may reduce concentration. During the period of treatment, you should refrain from driving and other complex devices.

special instructions

Some conditions of the body require dose adjustment of the drug or refusal of treatment with Dicinon.

Use in the elderly

in the treatment of the elderly and old age should take into account the presence chronic diseases that can become contraindications to the use of Dicinon.

Assignment to children

The drug can be used to treat children of any age.

Use during pregnancy and lactation

During pregnancy, Dicinon is used in the presence of vital indications.

If it is necessary to take Dicinon during lactation, breastfeeding is temporarily suspended.

Overdose of Dicinon 250

Cases of overdose have not been recorded. When used high doses the drug is carried out symptomatic therapy.

Interaction with other drugs

Etamzilat neutralizes the antiplatelet effect of dextrans. The drug is compatible with aminocaproic acid. injection form The medicinal product must not be mixed with other solutions. Dicynone is incompatible with sodium lactate and bicarbonate injection.

Alcohol compatibility

Etamzilat is incompatible with ethanol, so the introduction of Dicinon can not be carried out simultaneously with the use of alcohol.

Analogues

Pharmacological equivalents of the drug are:

  • Etamzilat;
  • Ethamlat;
  • Revolad.

Conditions for dispensing from a pharmacy

Strictly by prescription from a doctor.

Can I buy without a prescription

A hemostatic agent can only be bought with a prescription.

The price of Dicinon 250

The average cost of 10 tablets is 50 rubles.